| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6929 |
Name | TCF3 |
Synonymous | E2A|E47|ITF1|TCF-3|VDIR|bHLHb21;transcription factor 3;TCF3;transcription factor 3 |
Definition | VDR interacting repressor|class B basic helix-loop-helix protein 21|helix-loop-helix protein HE47|immunoglobulin transcription factor 1|kappa-E2-binding factor|negative vitamin D response element-binding protein|transcription factor 3 (E2A immunoglobulin |
Position | 19p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
E12(h) --> Myf6(r) (DNA binding). | E12(h) --> CD4(m) (DNA binding). | E12(h) --> Hbegf(m) (DNA binding). | E12(h) --> desmin(HA) (DNA binding). | E12(h) --> sTnI(QUAIL) (DNA binding). | E12(h) --> MLC(r) (DNA binding). | E12(h) --> C-ACT(c) (DNA binding; transregulation). | E12(h) --> Ig-kappa(m) (DNA binding). | E12(h) --> CKM(m) (DNA binding). | AS-C T3(d) + E12(h) <==> AS-C T3(d):E12(h) (binding). | AP-4(h) + E12(h) <==> AP-4(h):E12(h) (binding). | Tal1-PP42(h) + E12(h) <==> Tal1-PP42(h):E12(h) (binding). | E12(h) + MyoD(h) <==> E12(h):MyoD(h) (binding). | E47(h) + E12(h) <==> E47(h):E12(h) (binding). | Id1(m) + E12(h) <==> Id1(m):E12(h) (binding). | IEBP1(r) + E12(h) <==> IEBP1(r):E12(h) (binding). | E12(h) + MASH-1(r) <==> E12(h):MASH-1(r) (binding). | E12(h) + MASH-2(r) <==> E12(h):MASH-2(r) (binding). | E12(h) + MEF1(m) <==> E12(h):MEF1(m) (binding). | E12(h) + MRF4(r) <==> E12(h):MRF4(r) (binding). | E12(h) + Myogenin(h) <==> E12(h):Myogenin(h) (binding). | E12(h) + Myf-5(h) <==> E12(h):Myf-5(h) (binding). | E12(h) + Myf-6(h) <==> E12(h):Myf-6(h) (binding). | E12(h) + MyoD(x) <==> E12(h):MyoD(x) (binding). | E12(h) + MyoD(m) <==> E12(h):MyoD(m) (binding) | E12(h) + MyoD(mo) <==> E12(h):MyoD(mo) (binding). | E12(h) + myogenin(m) <==> E12(h):myogenin(m) (binding) | E12(h) + E47(r) <==> E12(h):E47(r) (binding). | SUM-1(LYT) + E12(h) <==> SUM-1(LYT):E12(h) (binding). | Myf-5(x) + E12(h) <==> Myf-5(x):E12(h) (binding). | MyoD(c) + E12(h) <==> MyoD(c):E12(h) (binding). | Id2(h) + E12(h) <==> Id2(h):E12(h) (binding). | HEN1(r) + E12(h) <==> HEN1(r):E12(h) (binding). | HTF4(h) + E12(h) <==> HTF4(h):E12(h) (binding). | EHAND(m) + E12(h) <==> EHAND(m):E12(h) (binding). | MASH-1(m) + E12(h) <==> MASH-1(m):E12(h) (binding) | MASH-1(h) + E12(h) <==> MASH-1(h):E12(h) (binding). | ASH-1(x) + E12(h) <==> ASH-1(x):E12(h) (binding). | Delilah(d) + E12(h) <==> Delilah(d):E12(h) (binding). | E47(m) + E12(h) <==> E47(m):E12(h) (binding). | INSAF(h) + E12(h) <==> INSAF(h):E12(h) (binding). | E12(h) + E12(h) <==> E12(h):E12(h) (binding). | E12(h) --> FOS(h) (DNA binding; transactivation). | E12(h) --> GLI1(h) (DNA binding). | BETA2(HA) + E12(h) <==> BETA2(HA):E12(h) (binding) | E12(h) --> NR0B2(h) (DNA binding; transactivation). | PIAS1(m) + E12(h) <==> PIAS1(m):E12(h) (binding) | S5a-Rpn10A(h) + E12(h) <==> S5a-Rpn10A(h):E12(h) (binding) | E12(h) + MyoD(m) <==> E12(h):MyoD(m) (binding) | Myogenin(m.s.) + E12(h) <==> Myogenin(m.s.):E12(h) (binding) | TWIST(h) + E12(h) <==> TWIST(h):E12(h) (binding) | E12(h) + Id1(m) <==> E12(h):Id1(m) (binding) | E12(h) + Id2(m) <==> E12(h):Id2(m) (binding) | E12(h) + Id3(m) <==> E12(h):Id3(m) (binding) | E12(h) + Id2(m) <==> E12(h):Id2(m) (binding) | E12(h) + MyoD(x) <==> E12(h):MyoD(x) (binding) | E12(h) + Lyl-1(h) <==> E12(h):Lyl-1(h) (binding) | E12(h) + HEF1(h) <==> E12(h):HEF1(h) (binding) | E12(h) + Dermo-1(m) <==> E12(h):Dermo-1(m) (binding) | E12(h) + scx(m) <==> E12(h):scx(m) (binding) | E12(h) + Tal-2(m) <==> E12(h):Tal-2(m) (binding) | E12(h) + Id(m) <==> E12(h):Id(m) (binding) | E12(h) --> CDKN1A(h) (DNA binding). | TCF3(h) --> E12(h) (expression). | E47(h) --> INS(r) (DNA binding). | E47(h) --> IgH(m) (DNA binding). | E47(h) --> Ig-kappa(m) (DNA binding). | E47(h) --> CKM(m) (DNA binding). | AS-C T3(d) + E47(h) <==> AS-C T3(d):E47(h) (binding). | E47(h) + E12(h) <==> E47(h):E12(h) (binding). | Tal1-PP42(h) + E47(h) <==> Tal1-PP42(h):E47(h) (binding) | Tal-2(h) + E47(h) <==> Tal-2(h):E47(h) (binding). | Tal1-PP22(h) + E47(h) <==> Tal1-PP22(h):E47(h) (binding) | E47(h) + MyoD(h) <==> E47(h):MyoD(h) (binding). | Id1(m) + E47(h) <==> Id1(m):E47(h) (binding). | Id2(m) + E47(h) <==> Id2(m):E47(h) (binding). | E47(h) + MEF1(m) <==> E47(h):MEF1(m) (binding). | E47(h) + MRF4(r) <==> E47(h):MRF4(r) (binding). | E47(h) + Myogenin(h) <==> E47(h):Myogenin(h) (binding). | E47(h) + Myf-5(h) <==> E47(h):Myf-5(h) (binding). | E47(h) + Myf-6(h) <==> E47(h):Myf-6(h) (binding). | E47(h) + MyoD(x) <==> E47(h):MyoD(x) (binding). | E47(h) + MyoD(m) <==> E47(h):MyoD(m) (binding). | E47(h) + MyoD(mo) <==> E47(h):MyoD(mo) (binding). | E47(h) + myogenin(m) <==> E47(h):myogenin(m) (binding). | E47(h) + E12(r) <==> E47(h):E12(r) (binding). | Myf-5(x) + E47(h) <==> Myf-5(x):E47(h) (binding). | MyoD(c) + E47(h) <==> MyoD(c):E47(h) (binding). | Id2(h) + E47(h) <==> Id2(h):E47(h) (binding). | HEN1(r) + E47(h) <==> HEN1(r):E47(h) (binding). | EHAND(m) + E47(h) <==> EHAND(m):E47(h) (binding). | Atoh2(m) + E47(h) <==> Atoh2(m):E47(h) (binding). | Tal-2(m) + E47(h) <==> Tal-2(m):E47(h) (binding). | BETA2(HA) + E47(h) <==> BETA2(HA):E47(h) (binding). | HES-5(r) + E47(h) <==> HES-5(r):E47(h) (binding). | IDB4(m) + E47(h) <==> IDB4(m):E47(h) (binding). | E12(x) + E47(h) <==> E12(x):E47(h) (binding). | E47(h) + E47(h) <==> E47(h):E47(h) (binding). | E47(h) --> FOS(h) (DNA binding). | E47(h) + BETA2(HA) <==> E47(h):BETA2(HA) (binding) | E47(h) --> NR0B2(h) (DNA binding; transactivation). | E47(h) + ATP --> E47(h){p} + ADP (phosphorylation) | n ubiquitin(h) + E47(h) --> E47(h){ub(n)} (ubiquitination) | E47(h) --> p27Kip1(h) (increase of abundance) | Skp2(h) + Skp1(h) + E47(h) <==> Skp2(h):Skp1(h):E47(h) (binding) | E47(h) --> p27Kip1(h):Skp2(h) (increase of binding) | E47(h) + Myogenin(m.s.) <==> E47(h):Myogenin(m.s.) (binding) | E47(h) + acetyl-CoA --p300(m.s.)--> E47(h){ace} + CoA (acetylation) | E47(h) + acetyl-CoA --CBP(m.s.)--> E47(h){ace} + CoA (acetylation) | E47(h) + acetyl-CoA --p/CAF(m.s.)--> E47(h){ace} + CoA (acetylation) | E47(h) + Id3(m) <==> E47(h):Id3(m) (binding) | Lyl-1(h) + E47(h) <==> Lyl-1(h):E47(h) (binding) | E47(h) + MAPKAPK3(h) <==> E47(h):MAPKAPK3(h) (binding) | E47(h) + MAPKAPK2(m.s.) <==> E47(h):MAPKAPK2(m.s.) (binding) | E47(h) + ATP --MAPKAPK3(h)--> E47(h){p} + ADP (phosphorylation) | E47(h) + ATP --MAPKAPK2(m.s.)--> E47(h){p} + ADP (phosphorylation) | E47(h) + HEF1(h) <==> E47(h):HEF1(h) (binding) | E47(h) + Tal-1(m) <==> E47(h):Tal-1(m) (binding) | E47(h) + Tal-1(m) + RBTN2(m.s.) <==> E47(h):Tal-1(m):RBTN2(m.s.) (binding) | E47(h) --> CDKN1A(h) (DNA binding). | TCF3(h) --> E47(h) (expression). | Jagged1(m) --/ E47(h) (decrease of abundance) | Notch1(h) --/ E47(h) (decrease of abundance) | MEK1(h) --/ E47(h) (decrease of abundance) | Skp2(m) --/ E47(h) (decrease of abundance) | ITF-1(h) --> INS(r) (DNA binding; transregulation). | ITF-1(h) + Id1(m) <==> ITF-1(h):Id1(m) (binding). | ITF-1(h) + MyoD(h) <==> ITF-1(h):MyoD(h) (binding). | ITF-2(h) + ITF-1(h) <==> ITF-2(h):ITF-1(h) (binding). | ITF-1(h) + Myogenin(h) <==> ITF-1(h):Myogenin(h) (binding). | ITF-1(h) + Myf-5(h) <==> ITF-1(h):Myf-5(h) (binding). | ITF-1(h) + Myf-6(h) <==> ITF-1(h):Myf-6(h) (binding). | ITF-1(h) + MyoD(x) <==> ITF-1(h):MyoD(x) (binding). | ITF-1(h) + MyoD(m) <==> ITF-1(h):MyoD(m) (binding). | ITF-1(h) + MyoD(mo) <==> ITF-1(h):MyoD(mo) (binding). | Myf-5(x) + ITF-1(h) <==> Myf-5(x):ITF-1(h) (binding). | MyoD(c) + ITF-1(h) <==> MyoD(c):ITF-1(h) (binding). | Lyl-1(h) + ITF-1(h) <==> Lyl-1(h):ITF-1(h) (binding) | TCF3(h) --> ITF-1(h) (expression). | CLIM2(h) + E2A(h) + RBTN2-isoform1(h) + Tal-1(h) <==> CLIM2(h):E2A(h):RBTN2-isoform1(h):Tal-1(h) (binding) | CLIM2(h) + E2A(h) + RBTN2-isoform1(h) + Tal-1(h) + pRb(h) <==> CLIM2(h):E2A(h):RBTN2-isoform1(h):Tal-1(h):pRb(h) (binding) | pRb(h) + E2A(h) <==> pRb(h):E2A(h) (binding) | p/CAF(h) + CBP(h) + p300(h) + E2A(h) <==> p/CAF(h):CBP(h):p300(h):E2A(h) (binding) | E2A(h) + p300(h) <==> E2A(h):p300(h) (binding) | E2A(h) + CBP(h) <==> E2A(h):CBP(h) (binding) | E2A(h) + p/CAF(h) <==> E2A(h):p/CAF(h) (binding) | Lyl-1(h) + E2A(h) <==> Lyl-1(h):E2A(h) (binding) | E2A(h) --> CYP19A1(h) (DNA binding). | TCF3(h) --> E2A(h) (expression). | Notch1(h) --/ E2A(h) (decrease of abundance) | MAPK(h) --/ E2A(h) (decrease of abundance) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr19 |
Promoter: 1600777 - 1602777 | GSE27584 |
chr19 |
Promoter: 1600777 - 1602777 | Agilent_014791_44K |