| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 695 |
Name | BTK |
Synonymous | AGMX1|AT|ATK|BPK|IMD1|PSCTK1|XLA;Bruton agammaglobulinemia tyrosine kinase;BTK;Bruton agammaglobulinemia tyrosine kinase |
Definition | B-cell progenitor kinase|agammaglobulinaemia tyrosine kinase|dominant-negative kinase-deficient Brutons tyrosine kinase|truncated Bruton agammaglobulinemia tyrosine kinase|tyrosine-protein kinase BTK|tyrosine-protein kinase BTK isoform (lacking exon 14) |
Position | Xq21.33-q22 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Btk(h) + TFII-I(h) <==> Btk(h):TFII-I(h) (binding) | TLR8(h) + Btk(h) <==> TLR8(h):Btk(h) (binding) | TLR4(h) + Btk(h) <==> TLR4(h):Btk(h) (binding) | TLR6(h) + Btk(h) <==> TLR6(h):Btk(h) (binding) | TLR9(h) + Btk(h) <==> TLR9(h):Btk(h) (binding) | MyD88(h) + Btk(h) <==> MyD88(h):Btk(h) (binding) | TIRAP(v.s.) + Btk(h) <==> TIRAP(v.s.):Btk(h) (binding) | IRAK1(h) + Btk(h) <==> IRAK1(h):Btk(h) (binding) | Btk(h) + ATP --> Btk(h){pY} + ADP (phosphorylation) | Btk(h) + FcReceptor-gamma(h) <==> Btk(h):FcReceptor-gamma(h) (binding) | Btk(h) + ATP --> Btk(h){p} + ADP (phosphorylation; automodification) | Btk(h) + ATP --> Btk(h){pT} + ADP (phosphorylation) | Btk(h) + PKCtheta(h) <==> Btk(h):PKCtheta(h) (binding) | Btk(h) --> PKCtheta(h){pY} (decrease of phosphorylation) | Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding) | Btk(h) + ATP --> Btk(h){p} + ADP (phosphorylation) | Btk(h) --/ Fas(c) (inhibition) | Btk(h) + Fas(c) <==> Btk(h):Fas(c) (binding) | Fas(h) + Btk(h) <==> Fas(h):Btk(h) (binding) | Btk(h) --> Fas(c):FADD(c) (decrease of binding) | Btk(h) --/ Fas(h) (inhibition) | Btk(h) + 2 ATP --> Btk(h){pY223}{pY551} + 2 ADP (phosphorylation) | Btk(h) + ATP --> Btk(h){pY223} + ADP (phosphorylation; automodification) | Btk(h) + CREB1(m.s.) <==> Btk(h):CREB1(m.s.) (binding) | MAL(h) + Btk(h) <==> MAL(h):Btk(h) (binding) | Btk(h) --> Btk(h) (expression). | TIRAP(m.s.) + ATP --Btk(h)--> TIRAP(m.s.){p} + ADP (phosphorylation) | Btk(h) + PKCtheta(h) <==> Btk(h):PKCtheta(h) (binding) | Btk(h) + STAT5A(h) <==> Btk(h):STAT5A(h) (binding) | STAT5A(m) + Btk(h) <==> STAT5A(m):Btk(h) (binding) | Btk(h) + ATP --> Btk(h){p} + ADP (phosphorylation; automodification) | ErbB2(h){pY1222} + Btk(h) <==> ErbB2(h){pY1222}:Btk(h) (binding) | Btk(h) + ATP --> Btk(h){pY} + ADP (phosphorylation; automodification) | Btk(h) --> Btk(h) (expression). | STAT5A(m) + ATP --Btk(h)--> STAT5A(m){pY} + ADP (phosphorylation) | STAT5A(m) + ATP --Btk(h)--> STAT5A(m){pY} + ADP (phosphorylation) | STAT5A(m) + ATP --Btk(h)--> STAT5A(m){pY694} + ADP (phosphorylation) | PLCgamma2(h) + ATP --Btk(h)--> PLCgamma2(h){pY} + ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-acetylalanine. | Swiss-Prot 53.0 | 223 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 551 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 550 | Phosphotyrosine (Lyn;BTK) | 8630736 | Phospho.ELM 6.0 | 222 | Phosphotyrosine (Abl;BTK) | 8630736;12445832 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
There is no record for BTK | ||