Entrez Gene

Basic Information
Gene ID	7057
Name	THBS1
Synonymous	THBS\|THBS-1\|TSP\|TSP-1\|TSP1;thrombospondin 1;THBS1;thrombospondin 1
Definition	thrombospondin-1\|thrombospondin-1p180
Position	15q15
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
LAP(h) + TSP-1(h) <==> LAP(h):TSP-1(h) (binding)
TSP-1(h) + GP4(h) <==> TSP-1(h):GP4(h) (binding)
TSP-1(h) + mmp2(h) <==> TSP-1(h):mmp2(h) (binding)
TSP-1(h) + gelatinase B(h) <==> TSP-1(h):gelatinase B(h) (binding)
TSP-1(h) + mmp2(m) <==> TSP-1(h):mmp2(m) (binding)
Antithrombin-III(m.s.) + thrombin(m.s.) + TSP-1(h) <==> Antithrombin-III(m.s.):thrombin(m.s.):TSP-1(h) (binding)
TSP-1(h) + PDI(h) <==> TSP-1(h):PDI(h) (binding)
TSP-1(h) --> p38(h){p} (increase of phosphorylation)
THBS1(h) --> TSP-1(h) (expression).
IGFBP-5(h) + TSP-1(h) <==> IGFBP-5(h):TSP-1(h) (binding)
TSP-1(h) + IGFBP-3(h) <==> TSP-1(h):IGFBP-3(h) (binding)
TSP-1(h) + IGFBP-4(h) <==> TSP-1(h):IGFBP-4(h) (binding)
THBS1(h) --> TSP-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
248	N-linked (GlcNAc...).		Swiss-Prot 53.0
360	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
708	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1067	N-linked (GlcNAc...).		Swiss-Prot 53.0
P0799	S	P07996	OGlycBase6.0
P0799	T	P07996	OGlycBase6.0
P0799	T	P07996	OGlycBase6.0
P0799	N	P07996	OGlycBase6.0
P0799	W	P07996	OGlycBase6.0
P0799	W	P07996	OGlycBase6.0
P0799	W	P07996	OGlycBase6.0
P0799	W	P07996	OGlycBase6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr15	Promoter: 37659072 - 37661072	Agilent_014791
chr15	Promoter: 37659072 - 37661072	GoldenGate_Methylation_Cancer_Panel_I
chr15	Promoter: 37659072 - 37661072	GSE27584
chr15	Promoter: 37659072 - 37661072	Agilent_014791_44K
chr15	Promoter: 37659072 - 37661072	Agilent_014791
chr15	Promoter: 37659072 - 37661072	PMID:14742272
chr15	Promoter: 37659072 - 37661072	PMID:14507661
chr15	Promoter: 37659072 - 37661072	PMID:11146446
chr15	Promoter: 37659072 - 37661072	PMID:16075282
chr15	Promoter: 37659072 - 37661072	PMID:17374440
chr15	Promoter: 37659072 - 37661072	PMID:11306456
chr15	Promoter: 37659072 - 37661072	PMID:12695555
chr15	Promoter: 37659072 - 37661072	PMID:12746473
chr15	Promoter: 37659072 - 37661072	PMID:12759541
chr15	Promoter: 37659072 - 37661072	PMID:12579314
chr15	Promoter: 37659072 - 37661072	PMID:16983315
chr15	Promoter: 37659072 - 37661072	PMID:14654541
chr15	Promoter: 37659072 - 37661072	PMID:15365725
chr15	Promoter: 37659072 - 37661072	PMID:15892004
chr15	Promoter: 37659072 - 37661072	PMID:12826052
chr15	Promoter: 37659072 - 37661072	PMID:16391867
chr15	Promoter: 37659072 - 37661072	PMID:15122305
chr15	Promoter: 37659072 - 37661072	PMID:15389252
chr15	Promoter: 37659072 - 37661072	PMID:16336454
chr15	Promoter: 37659072 - 37661072	PMID:15623630
chr15	Promoter: 37659072 - 37661072	PMID:15788647
chr15	Promoter: 37659072 - 37661072	PMID:14559817
chr15	Promoter: 37659072 - 37661072	PMID:12660028
chr15	Promoter: 37659072 - 37661072	PMID:16858686
chr15	Promoter: 37659072 - 37661072	PMID:15172987
chr15	Promoter: 37659072 - 37661072	PMID:17139617
chr15	Promoter: 37659072 - 37661072	PMID:10766168
chr15	Promoter: 37659072 - 37661072	PMID:12213730
chr15	Promoter: 37659072 - 37661072	PMID:12114423
chr15	Promoter: 37659072 - 37661072	PMID:12632081

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]