Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7249

Name

TSC2

Synonymous

LAM|PPP1R160|TSC4;tuberous sclerosis 2;TSC2;tuberous sclerosis 2

Definition

protein phosphatase 1, regulatory subunit 160|tuberin|tuberous sclerosis 2 protein

Position

16p13.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

tuberin(h) + RXR-alpha(h) <==> tuberin(h):RXR-alpha(h) (binding)
tuberin(h) + VDR(h) <==> tuberin(h):VDR(h) (binding)
14-3-3zeta(h) + tuberin(h) <==> 14-3-3zeta(h):tuberin(h) (binding)
tuberin(h) + NTP --AKT-1(h)--> tuberin(h){p} + NDP (phosphorylation)
AKT(h) + tuberin(h) <==> AKT(h):tuberin(h) (binding)
tuberin(h) + rheb(r) <==> tuberin(h):rheb(r) (binding)
tuberin(h) + ATP --AKT(v.s.)--> tuberin(h){pS939}{pT1462} + ADP (phosphorylation)
AKT(v.s.) + tuberin(h) <==> AKT(v.s.):tuberin(h) (binding)
tuberin(h) + GSK3beta(h) <==> tuberin(h):GSK3beta(h) (binding)
tuberin(h) + MycBP2(h) <==> tuberin(h):MycBP2(h) (binding)
tuberin(h) + R-Ras(v.s.) <==> tuberin(h):R-Ras(v.s.) (binding)
tuberin(h) + Rap1A(v.s.) <==> tuberin(h):Rap1A(v.s.) (binding)
tuberin(h) + RalA(v.s.) <==> tuberin(h):RalA(v.s.) (binding)
tuberin(h) + cyclinD1(m.s.) <==> tuberin(h):cyclinD1(m.s.) (binding)
tuberin(h) + cyclinD2(m.s.) <==> tuberin(h):cyclinD2(m.s.) (binding)
tuberin(h) + cyclinD3(m.s.) <==> tuberin(h):cyclinD3(m.s.) (binding)
Nek1(h) + tuberin(h) <==> Nek1(h):tuberin(h) (binding)
tuberin(h) + ubiquitin(h) --> tuberin(h){ub} (ubiquitination)
hamartin(h) + tuberin(h) <==> hamartin(h):tuberin(h) (binding)
14-3-3tau(h) + tuberin(h) <==> 14-3-3tau(h):tuberin(h) (binding)
tuberin(h) + ATP --> tuberin(h){p} + ADP (phosphorylation)
TSC2(h) --> tuberin(h) (expression).
rheb(r):GTP --tuberin(h)--> rheb(r):GDP + p (hydrolysis)
Rap1A(v.s.):GTP --tuberin(h)--> Rap1A(v.s.):GDP + p (hydrolysis)
TSC2(h) --> tuberin-isoform1(h) (expression).
TSC2(h) --> tuberin-isoform2(h) (expression).
TSC2(h) --> tuberin-isoform3(h) (expression).
TSC2(h) --> tuberin-isoform4(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

981Phosphoserine (By similarity).Swiss-Prot 53.0
1364Phosphoserine (By similarity).Swiss-Prot 53.0
1387Phosphoserine.Swiss-Prot 53.0
1411Phosphoserine.Swiss-Prot 53.0
1418Phosphoserine.Swiss-Prot 53.0
1420Phosphoserine.Swiss-Prot 53.0
1798Phosphoserine.Swiss-Prot 53.0
1254Phosphoserine (MAPKAPK2)12582162Phospho.ELM 6.0
1571Phosphotyrosine11290735Phospho.ELM 6.0
1411Phosphoserine17081983Phospho.ELM 6.0
981Phosphoserine15342917Phospho.ELM 6.0
664Phosphoserine (MAPK1)15851026Phospho.ELM 6.0
540Phosphoserine15851026Phospho.ELM 6.0
1420Phosphoserine15963462Phospho.ELM 6.0
1387Phosphoserine15963462Phospho.ELM 6.0
1418Phosphoserine15963462Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr16

Promoter: 2036491 - 2038491GSE27584

chr16

Promoter: 2036491 - 2038491GSE27584

chr16

Promoter: 2036491 - 2038491Agilent_014791_44K

chr16

Promoter: 2036491 - 2038491Agilent_014791

chr16

Promoter: 2036491 - 2038491PMID:15951164

chr16

Promoter: 2036491 - 2038491PMID:15951164


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