| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7249 |
Name | TSC2 |
Synonymous | LAM|PPP1R160|TSC4;tuberous sclerosis 2;TSC2;tuberous sclerosis 2 |
Definition | protein phosphatase 1, regulatory subunit 160|tuberin|tuberous sclerosis 2 protein |
Position | 16p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
tuberin(h) + RXR-alpha(h) <==> tuberin(h):RXR-alpha(h) (binding) | tuberin(h) + VDR(h) <==> tuberin(h):VDR(h) (binding) | 14-3-3zeta(h) + tuberin(h) <==> 14-3-3zeta(h):tuberin(h) (binding) | tuberin(h) + NTP --AKT-1(h)--> tuberin(h){p} + NDP (phosphorylation) | AKT(h) + tuberin(h) <==> AKT(h):tuberin(h) (binding) | tuberin(h) + rheb(r) <==> tuberin(h):rheb(r) (binding) | tuberin(h) + ATP --AKT(v.s.)--> tuberin(h){pS939}{pT1462} + ADP (phosphorylation) | AKT(v.s.) + tuberin(h) <==> AKT(v.s.):tuberin(h) (binding) | tuberin(h) + GSK3beta(h) <==> tuberin(h):GSK3beta(h) (binding) | tuberin(h) + MycBP2(h) <==> tuberin(h):MycBP2(h) (binding) | tuberin(h) + R-Ras(v.s.) <==> tuberin(h):R-Ras(v.s.) (binding) | tuberin(h) + Rap1A(v.s.) <==> tuberin(h):Rap1A(v.s.) (binding) | tuberin(h) + RalA(v.s.) <==> tuberin(h):RalA(v.s.) (binding) | tuberin(h) + cyclinD1(m.s.) <==> tuberin(h):cyclinD1(m.s.) (binding) | tuberin(h) + cyclinD2(m.s.) <==> tuberin(h):cyclinD2(m.s.) (binding) | tuberin(h) + cyclinD3(m.s.) <==> tuberin(h):cyclinD3(m.s.) (binding) | Nek1(h) + tuberin(h) <==> Nek1(h):tuberin(h) (binding) | tuberin(h) + ubiquitin(h) --> tuberin(h){ub} (ubiquitination) | hamartin(h) + tuberin(h) <==> hamartin(h):tuberin(h) (binding) | 14-3-3tau(h) + tuberin(h) <==> 14-3-3tau(h):tuberin(h) (binding) | tuberin(h) + ATP --> tuberin(h){p} + ADP (phosphorylation) | TSC2(h) --> tuberin(h) (expression). | rheb(r):GTP --tuberin(h)--> rheb(r):GDP + p (hydrolysis) | Rap1A(v.s.):GTP --tuberin(h)--> Rap1A(v.s.):GDP + p (hydrolysis) | TSC2(h) --> tuberin-isoform1(h) (expression). | TSC2(h) --> tuberin-isoform2(h) (expression). | TSC2(h) --> tuberin-isoform3(h) (expression). | TSC2(h) --> tuberin-isoform4(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
981 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1364 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1387 | Phosphoserine. | Swiss-Prot 53.0 | 1411 | Phosphoserine. | Swiss-Prot 53.0 | 1418 | Phosphoserine. | Swiss-Prot 53.0 | 1420 | Phosphoserine. | Swiss-Prot 53.0 | 1798 | Phosphoserine. | Swiss-Prot 53.0 | 1254 | Phosphoserine (MAPKAPK2) | 12582162 | Phospho.ELM 6.0 | 1571 | Phosphotyrosine | 11290735 | Phospho.ELM 6.0 | 1411 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 981 | Phosphoserine | 15342917 | Phospho.ELM 6.0 | 664 | Phosphoserine (MAPK1) | 15851026 | Phospho.ELM 6.0 | 540 | Phosphoserine | 15851026 | Phospho.ELM 6.0 | 1420 | Phosphoserine | 15963462 | Phospho.ELM 6.0 | 1387 | Phosphoserine | 15963462 | Phospho.ELM 6.0 | 1418 | Phosphoserine | 15963462 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr16 |
Promoter: 2036491 - 2038491 | GSE27584 |
chr16 |
Promoter: 2036491 - 2038491 | GSE27584 |
chr16 |
Promoter: 2036491 - 2038491 | Agilent_014791_44K |
chr16 |
Promoter: 2036491 - 2038491 | Agilent_014791 |
chr16 |
Promoter: 2036491 - 2038491 | PMID:15951164 |
chr16 |
Promoter: 2036491 - 2038491 | PMID:15951164 |