| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 861 |
Name | RUNX1 |
Synonymous | AML1|AML1-EVI-1|AMLCR1|CBFA2|EVI-1|PEBP2aB;runt-related transcription factor 1;RUNX1;runt-related transcription factor 1 |
Definition | AML1-EVI-1 fusion protein|CBF-alpha-2|PEA2-alpha B|PEBP2-alpha B|SL3-3 enhancer factor 1 alpha B subunit|SL3/AKV core-binding factor alpha B subunit|acute myeloid leukemia 1 protein|core-binding factor, runt domain, alpha subunit 2|oncogene AML-1|polyomav |
Position | 21q22.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
AML1(h) --> MPO(m) (DNA binding). | AML1(h) --> TCR-Vbeta 8.1(h) (DNA binding; transactivation). | AML1(h) + acetyl-CoA --> AML1(h){ace} + CoA (acetylation) | AML1(h) --/ LAT(h) (DNA binding; transrepression). | AML1(h) + C/EBPalpha(h) <==> AML1(h):C/EBPalpha(h) (binding) | CBP(h) + AML1(h) <==> CBP(h):AML1(h) (binding) | p300(h) + AML1(h) <==> p300(h):AML1(h) (binding) | AML1(h) --> uPA(h) (DNA binding). | AML1(h) --> CCL3(h) (DNA binding). | AML1(h) --> IL19(h) (DNA binding). | AML1(h) --> CHI3L1(h) (DNA binding). | AML1(h) --> DEFA1(h) (DNA binding). | AML1(h) --> DEFA3(h) (DNA binding). | AML1(h) --> CSF2(h) (DNA binding). | AML1(h) --> TCR-delta(h) (DNA binding). | AML1(h) --> CLC(h) (DNA binding). | RUNX1(h) --> AML1(h) (expression). | RUNX1(h) --> AML1DeltaN(h) (expression). | AML1b(h) + ATP --ERK(r)--> AML1b(h){p} + ADP (phosphorylation) | AML1b(h) + ERK(r) <==> AML1b(h):ERK(r) (binding) | AML1b(h) --> ADA(m) (DNA binding; transactivation). | AML1b(h) --/ CDKN1A(h) (transrepression) | sin3a(mo) + AML1b(h) <==> sin3a(mo):AML1b(h) (binding) | sin3a(h) + AML1b(h) <==> sin3a(h):AML1b(h) (binding) | mSin3B(mo) + AML1b(h) <==> mSin3B(mo):AML1b(h) (binding) | AML1b(h) + PEBP2beta(m.s.) <==> AML1b(h):PEBP2beta(m.s.) (binding) | AML1b(h) + PEBP2beta(m) + Hsp90(m) + Hsp70(m) + hipk2(m) + MOZ(m) <==> AML1b(h):PEBP2beta(m):Hsp90(m):Hsp70(m):hipk2(m):MOZ(m) (binding) | AML1b(h) + hipk2(h) <==> AML1b(h):hipk2(h) (binding) | AML1b(h) + 2 ATP --hipk2(h)--> AML1b(h){pS249}{pS276} + 2 ADP (phosphorylation) | AML1b(h) + 2 ATP --> AML1b(h){pS249}{pS276} + 2 ADP (phosphorylation) | p300(m.s.) + AML1b(h) <==> p300(m.s.):AML1b(h) (binding) | AML1b(h) + HIPK1(m) <==> AML1b(h):HIPK1(m) (binding) | AML1b(h) + MOZ(h) <==> AML1b(h):MOZ(h) (binding) | p300(h) + AML1b(h) <==> p300(h):AML1b(h) (binding) | AML1b(h) + p300(h) <==> AML1b(h):p300(h) (binding) | RUNX1(h) --> AML1b(h) (expression). | AML1c(h) --> IL3(h) (DNA binding). | RUNX1(h) --> AML1c(h) (expression). | AML1a(h) --> IL3(h) (DNA binding). | AML1a(h) --> BCL2(h) (DNA binding). | RUNX1(h) --> AML1a(h) (expression). | RUNX1(h) --> AML-1E(h) (expression). | RUNX1(h) --> AML-1FA(h) (expression). | RUNX1(h) --> AML-1FB(h) (expression). | RUNX1(h) --> AML-1FC(h) (expression). | RUNX1(h) --> AML-1G(h) (expression). | RUNX1(h) --> AML-1H(h) (expression). | RUNX1(h) --> AML-1I(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
14 | Phosphothreonine. | Swiss-Prot 53.0 | 21 | Phosphoserine. | Swiss-Prot 53.0 | 14 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 21 | Phosphoserine | 15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr21 |
Promoter: 35182357 - 35184357 | Agilent_014791 |
chr21 |
Promoter: 35182357 - 35184357 | GSE27584 |