Entrez Gene

Basic Information
Gene ID	864
Name	RUNX3
Synonymous	AML2\|CBFA3\|PEBP2aC;runt-related transcription factor 3;RUNX3;runt-related transcription factor 3
Definition	CBF-alpha-3\|PEA2 alpha C\|PEA2-alpha C\|PEBP2 alpha C\|PEBP2-alpha C\|SL3-3 enhancer factor 1 alpha C subunit\|SL3/AKV core-binding factor alpha C subunit\|acute myeloid leukemia 2 protein\|acute myeloid leukemia gene 2\|core-binding factor subunit alpha-3\|core-b
Position	1p36
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
AML2(h) --> CDKN1A(h) (transactivation)
AML2(h) --> KIR3DL3(h) (DNA binding).
AML2(h) --> KIR2DL3(h) (DNA binding).
AML2(h) --> KIR2DL4(h) (DNA binding).
RUNX3(h) --> AML2(h) (expression).
AML2-isoform1(h) --> CDKN1A(h) (transactivation)
Smad3(m.s.) + AML2-isoform1(h) <==> Smad3(m.s.):AML2-isoform1(h) (binding)
Smad4(m.s.) + AML2-isoform1(h) <==> Smad4(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + FOXO3a(m.s.) <==> AML2-isoform1(h):FOXO3a(m.s.) (binding)
FOXO3a(h) + AML2-isoform1(h) <==> FOXO3a(h):AML2-isoform1(h) (binding)
AML2-isoform1(h) + p300(h) <==> AML2-isoform1(h):p300(h) (binding)
p300(m.s.) + AML2-isoform1(h) <==> p300(m.s.):AML2-isoform1(h) (binding)
p300(h) + AML2-isoform1(h) <==> p300(h):AML2-isoform1(h) (binding)
AML2-isoform1(h) + 3 acetyl-CoA --p300(m.s.)--> AML2-isoform1(h){aceK148}{aceK186}{aceK192} + 3 CoA (acetylation)
AML2-isoform1(h) + PEBP2beta(m.s.) <==> AML2-isoform1(h):PEBP2beta(m.s.) (binding)
HDAC1(m.s.) + AML2-isoform1(h) <==> HDAC1(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + hdac2(m.s.) <==> AML2-isoform1(h):hdac2(m.s.) (binding)
AML2-isoform1(h) + HDAC5(m.s.) <==> AML2-isoform1(h):HDAC5(m.s.) (binding)
Smurf-1(m.s.) + AML2-isoform1(h) <==> Smurf-1(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + Smurf-2(m.s.) <==> AML2-isoform1(h):Smurf-2(m.s.) (binding)
AML2-isoform1(h) + ubiquitin(h) --Smurf-2(m.s.)--> AML2-isoform1(h){ub} (ubiquitination)
AML2-isoform1(h) + ubiquitin(h) --Smurf-1(m.s.)--> AML2-isoform1(h){ub} (ubiquitination)
RUNX3(h) --> AML2-isoform1(h) (expression).
AML2-isoform1(h){aceK} --HDAC5(m.s.)--> AML2-isoform1(h) + acetyl (deacetylation)
AML2-isoform1(h){aceK} --HDAC4(m.s.)--> AML2-isoform1(h) + acetyl (deacetylation)
RUNX3(h) --> AML2-isoform2(h) (expression).

Post Transcriptional Modification [Top]
	There is no record for RUNX3

Chromosome	Location	Source
Methylation Profile [Top]
chr1	Promoter: 25128857 - 25130857	Agilent_014791
chr1	Promoter: 25163588 - 25165588	GoldenGate_Methylation_Cancer_Panel_I
chr1	Promoter: 25128857 - 25130857	GSE27584
chr1	Promoter: 25163588 - 25165588	GSE27584
chr1	Promoter: 25163588 - 25165588	PMID:21796503
chr1	Promoter: 25128857 - 25130857	PMID:21796503
chr1	Promoter: 25163588 - 25165588	PMID:16328045
chr1	Promoter: 25128857 - 25130857	PMID:16328045
chr1	Promoter: 25163588 - 25165588	PMID:16234815
chr1	Promoter: 25128857 - 25130857	PMID:16234815
chr1	Promoter: 25163588 - 25165588	PMID:12841866
chr1	Promoter: 25128857 - 25130857	PMID:12841866
chr1	Promoter: 25163588 - 25165588	PMID:14968123
chr1	Promoter: 25128857 - 25130857	PMID:14968123
chr1	Promoter: 25163588 - 25165588	PMID:17270239
chr1	Promoter: 25128857 - 25130857	PMID:17270239
chr1	Promoter: 25163588 - 25165588	PMID:15273736
chr1	Promoter: 25128857 - 25130857	PMID:15273736
chr1	Promoter: 25163588 - 25165588	PMID:17372756
chr1	Promoter: 25128857 - 25130857	PMID:17372756
chr1	Promoter: 25163588 - 25165588	PMID:15051926
chr1	Promoter: 25128857 - 25130857	PMID:15051926
chr1	Promoter: 25163588 - 25165588	PMID:16367921
chr1	Promoter: 25128857 - 25130857	PMID:16367921
chr1	Promoter: 25163588 - 25165588	PMID:16818622
chr1	Promoter: 25128857 - 25130857	PMID:16818622
chr1	Promoter: 25163588 - 25165588	PMID:17139617
chr1	Promoter: 25128857 - 25130857	PMID:17139617
chr1	Promoter: 25163588 - 25165588	PMID:15471559
chr1	Promoter: 25128857 - 25130857	PMID:15471559
chr1	Promoter: 25163588 - 25165588	PMID:14743205
chr1	Promoter: 25128857 - 25130857	PMID:14743205
chr1	Promoter: 25163588 - 25165588	PMID:16155404
chr1	Promoter: 25128857 - 25130857	PMID:16155404
chr1	Promoter: 25163588 - 25165588	PMID:15447999
chr1	Promoter: 25128857 - 25130857	PMID:15447999
chr1	Promoter: 25163588 - 25165588	PMID:16230397
chr1	Promoter: 25128857 - 25130857	PMID:16230397
chr1	Promoter: 25163588 - 25165588	PMID:15596045
chr1	Promoter: 25128857 - 25130857	PMID:15596045
chr1	Promoter: 25163588 - 25165588	PMID:15574200
chr1	Promoter: 25128857 - 25130857	PMID:15574200

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]