Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

864

Name

RUNX3

Synonymous

AML2|CBFA3|PEBP2aC;runt-related transcription factor 3;RUNX3;runt-related transcription factor 3

Definition

CBF-alpha-3|PEA2 alpha C|PEA2-alpha C|PEBP2 alpha C|PEBP2-alpha C|SL3-3 enhancer factor 1 alpha C subunit|SL3/AKV core-binding factor alpha C subunit|acute myeloid leukemia 2 protein|acute myeloid leukemia gene 2|core-binding factor subunit alpha-3|core-b

Position

1p36

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

AML2(h) --> CDKN1A(h) (transactivation)
AML2(h) --> KIR3DL3(h) (DNA binding).
AML2(h) --> KIR2DL3(h) (DNA binding).
AML2(h) --> KIR2DL4(h) (DNA binding).
RUNX3(h) --> AML2(h) (expression).
AML2-isoform1(h) --> CDKN1A(h) (transactivation)
Smad3(m.s.) + AML2-isoform1(h) <==> Smad3(m.s.):AML2-isoform1(h) (binding)
Smad4(m.s.) + AML2-isoform1(h) <==> Smad4(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + FOXO3a(m.s.) <==> AML2-isoform1(h):FOXO3a(m.s.) (binding)
FOXO3a(h) + AML2-isoform1(h) <==> FOXO3a(h):AML2-isoform1(h) (binding)
AML2-isoform1(h) + p300(h) <==> AML2-isoform1(h):p300(h) (binding)
p300(m.s.) + AML2-isoform1(h) <==> p300(m.s.):AML2-isoform1(h) (binding)
p300(h) + AML2-isoform1(h) <==> p300(h):AML2-isoform1(h) (binding)
AML2-isoform1(h) + 3 acetyl-CoA --p300(m.s.)--> AML2-isoform1(h){aceK148}{aceK186}{aceK192} + 3 CoA (acetylation)
AML2-isoform1(h) + PEBP2beta(m.s.) <==> AML2-isoform1(h):PEBP2beta(m.s.) (binding)
HDAC1(m.s.) + AML2-isoform1(h) <==> HDAC1(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + hdac2(m.s.) <==> AML2-isoform1(h):hdac2(m.s.) (binding)
AML2-isoform1(h) + HDAC5(m.s.) <==> AML2-isoform1(h):HDAC5(m.s.) (binding)
Smurf-1(m.s.) + AML2-isoform1(h) <==> Smurf-1(m.s.):AML2-isoform1(h) (binding)
AML2-isoform1(h) + Smurf-2(m.s.) <==> AML2-isoform1(h):Smurf-2(m.s.) (binding)
AML2-isoform1(h) + ubiquitin(h) --Smurf-2(m.s.)--> AML2-isoform1(h){ub} (ubiquitination)
AML2-isoform1(h) + ubiquitin(h) --Smurf-1(m.s.)--> AML2-isoform1(h){ub} (ubiquitination)
RUNX3(h) --> AML2-isoform1(h) (expression).
AML2-isoform1(h){aceK} --HDAC5(m.s.)--> AML2-isoform1(h) + acetyl (deacetylation)
AML2-isoform1(h){aceK} --HDAC4(m.s.)--> AML2-isoform1(h) + acetyl (deacetylation)
RUNX3(h) --> AML2-isoform2(h) (expression).

Post Transcriptional Modification   [Top]

There is no record for RUNX3

Methylation Profile   [Top]

Chromosome

Location

Source

chr1

Promoter: 25128857 - 25130857Agilent_014791

chr1

Promoter: 25163588 - 25165588GoldenGate_Methylation_Cancer_Panel_I

chr1

Promoter: 25128857 - 25130857GSE27584

chr1

Promoter: 25163588 - 25165588GSE27584

chr1

Promoter: 25163588 - 25165588PMID:21796503

chr1

Promoter: 25128857 - 25130857PMID:21796503

chr1

Promoter: 25163588 - 25165588PMID:16328045

chr1

Promoter: 25128857 - 25130857PMID:16328045

chr1

Promoter: 25163588 - 25165588PMID:16234815

chr1

Promoter: 25128857 - 25130857PMID:16234815

chr1

Promoter: 25163588 - 25165588PMID:12841866

chr1

Promoter: 25128857 - 25130857PMID:12841866

chr1

Promoter: 25163588 - 25165588PMID:14968123

chr1

Promoter: 25128857 - 25130857PMID:14968123

chr1

Promoter: 25163588 - 25165588PMID:17270239

chr1

Promoter: 25128857 - 25130857PMID:17270239

chr1

Promoter: 25163588 - 25165588PMID:15273736

chr1

Promoter: 25128857 - 25130857PMID:15273736

chr1

Promoter: 25163588 - 25165588PMID:17372756

chr1

Promoter: 25128857 - 25130857PMID:17372756

chr1

Promoter: 25163588 - 25165588PMID:15051926

chr1

Promoter: 25128857 - 25130857PMID:15051926

chr1

Promoter: 25163588 - 25165588PMID:16367921

chr1

Promoter: 25128857 - 25130857PMID:16367921

chr1

Promoter: 25163588 - 25165588PMID:16818622

chr1

Promoter: 25128857 - 25130857PMID:16818622

chr1

Promoter: 25163588 - 25165588PMID:17139617

chr1

Promoter: 25128857 - 25130857PMID:17139617

chr1

Promoter: 25163588 - 25165588PMID:15471559

chr1

Promoter: 25128857 - 25130857PMID:15471559

chr1

Promoter: 25163588 - 25165588PMID:14743205

chr1

Promoter: 25128857 - 25130857PMID:14743205

chr1

Promoter: 25163588 - 25165588PMID:16155404

chr1

Promoter: 25128857 - 25130857PMID:16155404

chr1

Promoter: 25163588 - 25165588PMID:15447999

chr1

Promoter: 25128857 - 25130857PMID:15447999

chr1

Promoter: 25163588 - 25165588PMID:16230397

chr1

Promoter: 25128857 - 25130857PMID:16230397

chr1

Promoter: 25163588 - 25165588PMID:15596045

chr1

Promoter: 25128857 - 25130857PMID:15596045

chr1

Promoter: 25163588 - 25165588PMID:15574200

chr1

Promoter: 25128857 - 25130857PMID:15574200


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