Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

8772

Name

FADD

Synonymous

GIG3|MORT1;Fas (TNFRSF6)-associated via death domain;FADD;Fas (TNFRSF6)-associated via death domain

Definition

FAS-associated death domain protein|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor induced toxicity|mediator of receptor-induced toxicity

Position

11q13.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding)
FADD(h) + proCaspase-8a(h) <==> FADD(h):proCaspase-8a(h) (binding)
FADD(h) + proCaspase-8d(h) <==> FADD(h):proCaspase-8d(h) (binding)
c-FLIP-S(h) + FADD(h) <==> c-FLIP-S(h):FADD(h) (binding)
c-FLIP-S(h) + FADD(h) + Fas(m) <==> c-FLIP-S(h):FADD(h):Fas(m) (binding)
c-FLIP-L(h) + FADD(h) + Fas(m) <==> c-FLIP-L(h):FADD(h):Fas(m) (binding)
c-FLIP-L-p43(h) + FADD(h) + Fas(h) + FasL(h) + proCaspase-8(h) <==> FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding)
Apo2L(h) + FADD(h) <==> Apo2L(h):FADD(h) (binding)
FasL(h) + FADD(h) <==> FasL(h):FADD(h) (binding)
FADD(h) + FAF1(h) <==> FADD(h):FAF1(h) (binding)
FADD(h) + DEDD(v.s.) <==> FADD(h):DEDD(v.s.) (binding)
DR5(h) + FADD(h) <==> DR5(h):FADD(h) (binding)
FADD(h) + TRADD(h) <==> FADD(h):TRADD(h) (binding)
FADD(h) + proCaspase-8(h) <==> FADD(h):proCaspase-8(h) (binding)
proCaspase-8(h) + Apo2L(h) + FADD(h) + DR5(h) <==> proCaspase-8(h):Apo2L(h):FADD(h):DR5(h) (binding)
proCaspase-10(h) + Apo2L(h) + FADD(h) + DR5(h) <==> proCaspase-10(h):Apo2L(h):FADD(h):DR5(h) (binding)
FADD(h) + FasL(h) + Fas(h) + proCaspase-10(h) <==> FADD(h):FasL(h):Fas(h):proCaspase-10(h) (binding)
FADD(h) + DEDD(m.s.) <==> FADD(h):DEDD(m.s.) (binding)
proCaspase-10(h) + FADD(h) + Fas(h) <==> proCaspase-10(h):FADD(h):Fas(h) (binding)
proCaspase-10(h) + DR5(h) + FADD(h) <==> proCaspase-10(h):DR5(h):FADD(h) (binding)
proCaspase-10(h) + DR4(m.s.) + FADD(h) <==> proCaspase-10(h):DR4(m.s.):FADD(h) (binding)
FADD(h) + FasL(h) + Fas(h) <==> FADD(h):FasL(h):Fas(h) (binding)
FADD(h) + ABC-1(h) <==> FADD(h):ABC-1(h) (binding)
FADD(h) + Fas(h) + c-FLIP-L-p43(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h) (binding)
FADD(h) + PKCzeta(h) <==> FADD(h):PKCzeta(h) (binding)
FADD(h) + ATP --PKCzeta(h)--> FADD(h){p} + ADP (phosphorylation)
FADD(h) + CKI-alpha(h) <==> FADD(h):CKI-alpha(h) (binding)
FADD(h) + ATP --CKI-alpha(h)--> FADD(h){pS194} + ADP (phosphorylation)
MBD4(h) + FADD(h) <==> MBD4(h):FADD(h) (binding)
FADD(h) --> FAF1(m.s.) (activation)
c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-10(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-10(h) (binding)
c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-8(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-8(h) (binding)
c-FLIP-L-p43(h) + FADD(h) + proCaspase-8(h) + Fas(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h):proCaspase-8(h) (binding)
Apo2L(m.s.) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) + c-FLIP-S(h) <==> Apo2L(m.s.):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h):c-FLIP-S(h) (binding)
Apo2L(h) + DR5(h) + FADD(h) + proCaspase-8(h) + c-FLIP-L(h) <==> Apo2L(h):DR5(h):FADD(h):proCaspase-8(h):c-FLIP-L(h) (binding)
Fas(h) + FasL(h) + c-FLIP-S(m.s.) + FADD(h) + proCaspase-8(h) + c-FLIP-L-p43(h) <==> Fas(h):FasL(h):c-FLIP-S(m.s.):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding)
Fas(h) + FasL(h) + FADD(h) + Caspase-8-p43(h) + c-FLIP-L-p43(m.s.) <==> Fas(h):FasL(h):FADD(h):Caspase-8-p43(h):c-FLIP-L-p43(m.s.) (binding)
Apo2L(m.s.) + FADD(h) + c-FLIP-L(m.s.) + Caspase-8-p43(h) <==> Apo2L(m.s.):FADD(h):c-FLIP-L(m.s.):Caspase-8-p43(h) (binding)
proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h) (binding)
proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h):c-FLIP-S(h) (binding)
DR4(h) + DR5(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> DR4(h):DR5(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding)
Fas(h) + Caspase-8-p43(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> Fas(h):Caspase-8-p43(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding)
TRAF2(h) + TRADD(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) <==> TRAF2(h):TRADD(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h) (binding)
Fas(h) + FADD(h) + proCaspase-8(h) + c-FLIP-p22(m.s.) <==> Fas(h):FADD(h):proCaspase-8(h):c-FLIP-p22(m.s.) (binding)
Fas(h) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding)
Fas(h) + FADD(h) + c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding)
Fas(h) + FADD(h) + c-FLIP-S(h) + c-FLIP-L-p43(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):c-FLIP-S(h):c-FLIP-L-p43(h):Caspase-8-p43(h) (binding)
PIDD(m) + FADD(h) <==> PIDD(m):FADD(h) (binding)
PIDD(h) + FADD(h) <==> PIDD(h):FADD(h) (binding)
Fas(h) + FADD(h) + Caspase-8-p18(h) + Caspase-2-p33(h) <==> Fas(h):FADD(h):Caspase-8-p18(h):Caspase-2-p33(h) (binding)
Fas(h) + FADD(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):proCaspase-2(h):Caspase-8-p43(h) (binding)
FADD(h) + proCaspase-2(h) <==> FADD(h):proCaspase-2(h) (binding)
Fas(h) + FADD(h) + proCaspase-8(h) <==> Fas(h):FADD(h):proCaspase-8(h) (binding)
APG5(h) + FADD(h) <==> APG5(h):FADD(h) (binding)
FADD(h) + ATP --> FADD(h){pS194} + ADP (phosphorylation)
proCaspase-8(h) + FADD(h) <==> proCaspase-8(h):FADD(h) (binding)
DAP3(h) + FADD(h) <==> DAP3(h):FADD(h) (binding)
Caspase-8(h) + FADD(h) <==> Caspase-8(h):FADD(h) (binding)
proCaspase-8(h) + FADD(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding)
FADD(h) + IRAK1(h) <==> FADD(h):IRAK1(h) (binding)
FADD(h) + RIP(m.s.) <==> FADD(h):RIP(m.s.) (binding)
Caspase-8-p43(h) + FasL(h) + FADD(h) + Fas(h) <==> Caspase-8-p43(h):FasL(h):FADD(h):Fas(h) (binding)
c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding)
c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding)
c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8a-p43(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8a-p43(h):FADD(h):Fas(h) (binding)
c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8b-p41(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8b-p41(h):FADD(h):Fas(h) (binding)
FADD(h) --> FADD(h) (expression).
PAR4(m.s.) --> FADD(h) (decrease of phosphorylation)
TNFR1(h) --> FADD(h) (binding)
proCaspase-8(h) --> FADD(h) (binding)
TRADD(h) --> FADD(h) (binding)
TRAF2(h) --> FADD(h) (binding)
Fas(h) + proCaspase-8(h) + FADD(h) <==> Fas(h):proCaspase-8(h):FADD(h) (binding)
Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding)
2 FADD(h) <==> (FADD(h))2 (oligomerization)
FADD(h) --> FADD(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

194Phosphoserine (Probable).Swiss-Prot 53.0
194Phosphoserine (70-kDa kinas)11034606;10640736;15001534Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

 Promoter: 69725417 - 69727417Agilent_014791

chr11

 Promoter: 69725417 - 69727417GSE27584

chr11

 Promoter: 69725417 - 69727417Agilent_014791_44K

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