| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 9656 |
Name | MDC1 |
Synonymous | NFBD1;mediator of DNA-damage checkpoint 1;MDC1;mediator of DNA-damage checkpoint 1 |
Definition | homologue to Drosophila photoreceptor protein calphotin|mediator of DNA damage checkpoint 1|mediator of DNA damage checkpoint protein 1|nuclear factor with BRCT domains 1 |
Position | 6p21.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
NFBD1(h) + STAT1(h) <==> NFBD1(h):STAT1(h) (binding) | NFBD1(h) --> Chk2(h){pT68} (increase of phosphorylation) | NFBD1(h) --> p53(h){pS15} (increase of phosphorylation) | NFBD1(h) --> NBS1(h){pS343} (increase of phosphorylation) | h2ax(h){pS140} + NFBD1(h) <==> h2ax(h){pS140}:NFBD1(h) (binding) | topoisomerase-II-alpha(h) + NFBD1(h) <==> topoisomerase-II-alpha(h):NFBD1(h) (binding) | NFBD1(h) + topoisomerase-II-alpha-isoform1(h) <==> NFBD1(h):topoisomerase-II-alpha-isoform1(h) (binding) | MDC1(h) --> NFBD1(h) (expression). | MDC1(h) --> NFBD1-isoform1(h) (expression). | MDC1(h) --> NFBD1-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
168 | Phosphoserine. | Swiss-Prot 53.0 | 329 | Phosphoserine. | Swiss-Prot 53.0 | 331 | Phosphothreonine. | Swiss-Prot 53.0 | 402 | Phosphoserine. | Swiss-Prot 53.0 | 404 | Phosphothreonine. | Swiss-Prot 53.0 | 453 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 455 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 495 | Phosphoserine. | Swiss-Prot 53.0 | 498 | Phosphoserine. | Swiss-Prot 53.0 | 882 | Phosphoserine. | Swiss-Prot 53.0 | 964 | Phosphoserine. | Swiss-Prot 53.0 | 988 | Phosphoserine. | Swiss-Prot 53.0 | 995 | Phosphoserine. | Swiss-Prot 53.0 | 1425 | Phosphothreonine. | Swiss-Prot 53.0 | 1461 | Phosphothreonine. | Swiss-Prot 53.0 | 1797 | Phosphoserine. | Swiss-Prot 53.0 | 168 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 329 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 455 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 964 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 988 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 995 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1425 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 1444 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 1461 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 1526 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 331 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 402 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 404 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 449 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 495 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 498 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 793 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 882 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 998 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
There is no record for MDC1 | ||