| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 11122 |
Name | PTPRT |
Synonymous | RPTPrho;protein tyrosine phosphatase, receptor type, T;PTPRT;protein tyrosine phosphatase, receptor type, T |
Definition | R-PTP-T|RPTP-rho|receptor protein tyrosine phosphatase|receptor-type tyrosine-protein phosphatase T|receptor-type tyrosine-protein phosphatase rho |
Position | 20q12-q13 |
Gene type | protein-coding |
|
Title |
Abstract |
| Tumour suppressor function of protein tyrosine phosphatase receptor-T. | It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like PTPs, is the most frequently mutated PTP among them. Consistent with the notion that PTPRT is a tumour suppressor, PTPRT knockout mice are hypersensitive to AOM (azoxymethane)-induced colon cancer. The present review focuses on the physiological and pathological functions of PTPRT as well as the cellular pathways regulated by this phosphatase. |