| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1959 |
Name | EGR2 |
Synonymous | AT591|CMT1D|CMT4E|KROX20;early growth response 2;EGR2;early growth response 2 |
Definition | E3 SUMO-protein ligase EGR2|KROX-20, Drosophila, homolog (early growth response-2)|early growth response protein 2|zinc finger protein Krox-20 |
Position | 10q21.1 |
Gene type | protein-coding |
|
Title |
Abstract |
| MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2. | Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer. |