| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 199 |
Name | AIF1 |
Synonymous | AIF-1|IBA1|IRT-1|IRT1;allograft inflammatory factor 1;AIF1;allograft inflammatory factor 1 |
Definition | allograft inflammatory factor-1 splice variant Hara-1|interferon gamma responsive transcript|ionized calcium-binding adapter molecule 1|protein G1 |
Position | 6p21.3 |
Gene type | protein-coding |
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Title |
Abstract |
| Allograft inflammatory factor-1 is an independent prognostic indicator that regulates beta-catenin in gastric cancer. | Previous studies have revealed that expression of allograft inflammatory factor-1 (AIF-1) protein appears to be increased in malignancies and is correlated with a poorer prognosis in cervical cancer, while its role in gastric cancer has not been reported. We analyzed the expression of AIF-1 in 78 cancer lesions and the corresponding non-cancerous tissues by immunohistochemistry. In contrast with other cancers, we found that AIF-1 protein levels were significantly decreased in 53 of the 78 (67.9%) gastric cancer tissues when compared with the matched normal tissues. This was further confirmed using 7 pairs of fresh gastric cancer tissues and matched adjacent normal tissues. Low tumoral AIF-1 expression was significantly correlated with less favorable clinicopathological characteristics, as well as with reduced overall survival (P<0.001) in the gastric cancer patients. Furthermore, knockdown of AIF-1 obviously increased proliferation, migration and beta-catenin expression in BGC-823 and SGC-7901 gastric cancer cells. Taken together, for the first time, we provide evidence that the level of AIF-1 expression may serve as a protective prognostic indicator for gastric cancer. |