| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 407019 |
Name | MIR27B |
Synonymous | MIR-27b|MIRN27B|miRNA27B;microRNA 27b;MIR27B;microRNA 27b |
Definition | hsa-mir-27b |
Position | 9q22.32 |
Gene type | ncRNA |
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Title |
Abstract |
| MiR-27b targets PPARgamma to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. | The peroxisome proliferators-activated receptor (PPAR)gamma pathway is involved in cancer, but it appears to have both tumor suppressor and oncogenic functions. In neuroblastoma cells, miR-27b targets the 3 untranslated region of PPARgamma and inhibits its mRNA and protein expression. miR-27b overexpression or PPARgamma inhibition blocks cell growth in vitro and tumor growth in mouse xenografts. PPARgamma activates expression of the pH regulator NHE1, which is associated with tumor progression. Lastly, miR-27b through PPARgamma regulates nuclear factor-kappaB activity and transcription of inflammatory target genes. Thus, in neuroblastoma, miR-27b functions as a tumor suppressor by inhibiting the tumor-promoting function of PPARgamma, which triggers an increased inflammatory response. In contrast, in breast cancer cells, PPARgamma inhibits NHE1 expression and the inflammatory response, and it functions as a tumor suppressor. We suggest that the ability of PPARgamma to promote or suppress tumor formation is linked to cell type-specific differences in regulation of NHE1 and other target genes. |