| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8572 |
Name | PDLIM4 |
Synonymous | RIL;PDZ and LIM domain 4;PDLIM4;PDZ and LIM domain 4 |
Definition | LIM domain protein|LIM protein RIL|PDZ and LIM domain protein 4|enigma homolog|reversion-induced LIM protein |
Position | 5q31.1 |
Gene type | protein-coding |
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Title |
Abstract |
| PDLIM4, an actin binding protein, suppresses prostate cancer cell growth. | We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. |