| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 8856 |
Name | NR1I2 |
Synonymous | BXR|ONR1|PAR|PAR1|PAR2|PARq|PRR|PXR|SAR|SXR;nuclear receptor subfamily 1, group I, member 2;NR1I2;nuclear receptor subfamily 1, group I, member 2 |
Definition | nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor |
Position | 3q12-q13.3 |
Gene type | protein-coding |
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Title |
Abstract |
| B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. | The steroid and xenobiotic receptor (SXR) is a broad-specificity nuclear hormone receptor that is highly expressed in the liver and intestine, where its primary function is to regulate drug and xenobiotic metabolism. SXR is expressed at lower levels in other tissues, where little is known about its physiological functions. We previously linked SXR with immunity and inflammation by showing that SXR antagonizes the activity of nuclear factor (NF)-kappaB in vitro and in vivo. SXR(-/-) mice demonstrate aberrantly high NF-kappaB activity and overexpression of NF-kappaB target genes. Here we show that SXR(-/-) mice develop B cell lymphoma in an age-dependent manner. SXR(-/-) mice develop multiple hyperplastic lymphoid foci composed of B-1a cells in the intestine, spleen, lymph nodes, peritoneal cavity, and blood. In all circumstances, these lymphocytes possess cell surface and molecular characteristics of either chronic lymphocytic leukemia or non-Hodgkins lymphoma originating from B-1 lymphocytes. These results demonstrate a novel and unsuspected role for SXR signaling in the B-1 cell compartment, establish SXR as a tumor suppressor in B-1 cells, and may provide a link between metabolism of xenobiotic compounds and lymphomagenesis. |