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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10152 |
Name | ABI2 |
Synonym | ABI-2|ABI2B|AIP-1|AblBP3|SSH3BP2|argBPIA|argBPIB;abl-interactor 2;ABI2;abl-interactor 2 |
Definition | abelson interactor 2|abl binding protein 3|abl interactor 2|abl-binding protein 3|abl-interacting protein 1 (SH3-containing protein)|abl-interactor protein 2b|arg protein tyrosine kinase-binding protein|arg-binding protein 1|argBP1 |
Position | 2q33 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | The properties of Abi-2 are consistent with a dual role as regulator and potential effector of the c-Abl protein and suggest that Abi-2 may function as a tumor suppressor in mammalian cells. |
reviewed | "TRIM32 promotes cell migration through ubiquitination of Abl interactor 2 (Abi2), a tumor suppressor." |
reviewed | "In this study, we found by using yeast two-hybrid screening that TRIM32 binds to Abl-interactor 2 (Abi2), which is known as a tumor suppressor and a cell migration inhibitor, and we showed that TRIM32 mediates the ubiquitination of Abi2." |
| More detail of all 3 literatures about ABI2 | |
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Pathways and Diseases |
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Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Disease | subclinical atherosclerosis traits (other);GAD |
Disease | Subclinical atherosclerosis traits (other);NHGRI |
Disease | Fibroid tumor;FunDO |
Disease | Neoplasm metastasis;FunDO |
Disease | CARDIOVASCULAR;GAD |
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External Links |
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Links to Entrez Gene | 10152 |
Links to all GeneRIF Items | 10152 |
Links to iHOP | 10152 |
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Sequence Information |
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Nucleotide Sequence |
>10152 : length: 1428 atggcggagctgcagatgctgctggaagaggaaatcccggggggccgccgggccctcttc gacagctacacaaatctggaacgggtggccgattactgcgagaacaactacatacagtca gcagataagcagagagccctagaagaaaccaaagcctacaccacccaatccttagcaagt gttgcctatctgataaacaccttggccaacaatgtcctgcagatgctggatatccaggca tcccagctacgaaggatggaatcttcaatcaatcatatttcacaaacagttgatattcat aaagagaaagttgcaagaagagaaattggtattttgactaccaataaaaacacttcaagg acacataagattattgctccagccaaccttgaacgaccagttcgttatattagaaaacct attgactatacaattctagatgatattggacatggagtaaaggtgagtacccagaacatg aagatgggtgggctgccgcgtacaacacctccaactcagaagccccctagtccccctatg tcagggaaagggacacttgggcggcactccccctatcgcacactggagccagtgcgtcct ccagtggtaccaaatgattacgtacctagcccaacccgtaatatggctccctcgcagcag agccctgtgaggacagcttctgtgaatcaaagaaatcgaacttacagcagcagtgggagt agtggagggagccacccaagtagtcggagcagcagtcgagagaacagtggaagtggtagt gtgggggttcctattgctgttcctactccatctcctcccagtgtctttccaggtcatcct gtacagttctacagcatgaataggcctgcctctcgccatactcccccaacaatagggggc tcgttgccctatagacgccctccttccattacttcacaaacaagccttcagaatcagatg aatggaggacctttttatagccagaatccagtatctcttgctcctcctcctccctccatc ctacaggtaactcctcagttacctttaatgggatttgtggccagagtccaagaaaatatt tcagatacaccacctccaccgccacctgtggaagaaccagtctttgatgagtctccccca cctcctcctcctccagaagattacgaagaggaggaagctgctgtggttgagtatagtgat ccttatgctgaagaggacccaccgtgggctccacgttcttacttggaaaaggttgtggca atttatgactatacaaaagacaaggaagatgagctgtcctttcaggaaggagccattatt tatgtcatcaagaagaatgacgatggttggtatgagggagttatgaatggagtgactggg ctttttcctgggaattacgttgagtctatcatgcattattctgagtaa |
Protein Sequence |
>10152 : length: 475 MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLAS VAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR THKIIAPANLERPVRYIRKPIDYTILDDIGHGVKVSTQNMKMGGLPRTTPPTQKPPSPPM SGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGS SGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHPVQFYSMNRPASRHTPPTIGG SLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLPLMGFVARVQENI SDTPPPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVA IYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE |