Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

10154

Name

PLXNC1

Synonym

CD232|PLXN-C1|VESPR;plexin C1;PLXNC1;plexin C1

Definition

plexin (semaphorin receptor)|plexin-C1|receptor for viral semaphorin protein|receptor for virally-encoded semaphorin|virus-encoded semaphorin protein receptor

Position

12q23.3

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 2 PubMed records as below.

Evidence Status

Description

potential

"significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma".

potential

"Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression."
More detail of all 2 literatures about PLXNC1

Pathways and Diseases

Pathway

Other semaphorin interactions;PID Reactome;500078

Pathway

Axon guidance;KEGG PATHWAY;hsa04360

Pathway

Axon guidance;Reactome;REACT:18266

Disease

Melanoma;FunDO

External Links

Links to Entrez Gene

10154

Links to all GeneRIF Items

10154

Links to iHOP

10154

Sequence Information

Nucleotide Sequence

>10154 : length: 4707
atggaggtctcccggaggaaggcgccgccgcgccccccgcgccccgcagcgccactgccc
ctgctcgcctatctgctggcactggcggctcccggccggggcgcggacgagcccgtgtgg
cggtcggagcaagccatcggagccatcgcggcgagccaggaggacggcgtgtttgtggcg
agcggcagctgcctggaccagctggactacagcctggagcacagcctctcgcgcctgtac
cgggaccaagcgggcaactgcacagagccggtctcgctggcgccccccgcgcggccccgg
cccgggagcagcttcagcaagctgctgctgccctaccgcgagggggcggccggcctcggg
gggctgctgctcaccggctggaccttcgaccggggcgcctgcgaggtgcggcccctgggc
aacctgagccgcaactccctgcgcaacggcaccgaggtggtgtcgtgccacccgcagggc
tcgacggccggcgtggtgtaccgcgcgggccggaacaaccgctggtacctggcggtggcc
gccacctacgtgctgcctgagccggagacggcgagccgctgcaaccccgcggcatccgac
cacgacacggccatcgcgctcaaggacacggaggggcgcagcctggccacgcaggagctg
gggcgcctcaagctgtgcgagggcgcgggcagcctgcacttcgtggacgcctttctctgg
aacggcagcatctacttcccctactacccctacaactacacgagcggcgctgccaccggc
tggcccagcatggcgcgcatcgcgcagagcaccgaggtgctgttccagggccaggcatcc
ctcgactgcggccacggccaccccgacggccgccgcctgctcctctcctccagcctagtg
gaggccctggacgtctgggcgggagtgttcagcgcggccgctggagagggccaggagcgg
cgctcccccaccaccacggcgctctgcctcttcagaatgagtgagatccaggcgcgcgcc
aagagggtcagctgggacttcaagacggccgagagccactgcaaagaaggggatcaacct
gaaagagtccaaccaatcgcatcatctaccttgatccattccgacctgacatccgtttat
ggcaccgtggtaatgaacaggactgttttattcttggggactggagatggccagttactt
aaggttattcttggtgagaatttgacttcaaattgtccagaggttatctatgaaattaaa
gaagagacacctgttttctacaaactcgttcctgatcctgtgaagaatatctacatttat
ctaacagctgggaaagaggtgaggagaattcgtgttgcaaactgcaataaacataaatcc
tgttcggagtgtttaacagccacagaccctcactgcggttggtgccattcgctacaaagg
tgcacttttcaaggagattgtgtacattcagagaacttagaaaactggctggatatttcg
tctggagcaaaaaagtgccctaaaattcagataattcgaagcagtaaagaaaagactaca
gtgactatggtgggaagcttctctccaagacactcaaagtgcatggtgaagaatgtggac
tctagcagggagctctgccagaataaaagtcagcccaaccggacctgcacctgtagcatc
ccaaccagagcaacctacaaagatgtttcagttgtcaacgtgatgttctccttcggttct
tggaatttatcagacagattcaactttaccaactgctcatcattaaaagaatgcccagca
tgcgtagaaactggctgcgcgtggtgtaaaagtgcaagaaggtgtatccaccccttcaca
gcttgcgacccttctgattatgagagaaaccaggaacagtgtccagtggctgtcgagaag
acatcaggaggaggaagacccaaggagaacaaggggaacagaaccaaccaggctttacag
gtcttctacattaagtccattgagccacagaaagtatcgacattagggaaaagcaacgtg
atagtaacgggagcaaactttacccgggcatcgaacatcacaatgatcctgaaaggaacc
agtacctgtgataaggatgtgatacaggttagccatgtgctaaatgacacccacatgaaa
ttctctcttccatcaagccggaaagaaatgaaggatgtgtgtatccagtttgatggtggg
aactgctcttctgtgggatccttatcctacattgctctgccacattgttcccttatattt
cctgctaccacctggatcagtggtggtcaaaatataaccatgatgggcagaaattttgat
gtaattgacaacttaatcatttcacatgaattaaaaggaaacataaatgtctctgaatat
tgtgtggcgacttactgcgggtttttagcccccagtttaaagagttcaaaagtgcgcacg
aatgtcactgtgaagctgagagtacaagacacctacttggattgtggaaccctgcagtat
cgggaggaccccagattcacggggtatcgggtggaatccgaggtggacacagaactggaa
gtgaaaattcaaaaagaaaatgacaacttcaacatttccaaaaaagacattgaaattact
ctcttccatggggaaaatgggcaattaaattgcagttttgaaaatattactagaaatcaa
gatcttaccaccatcctttgcaaaattaaaggcatcaagactgcaagcaccattgccaac
tcttctaagaaagttcgggtcaagctgggaaacctggagctctacgtcgagcaggagtca
gttccttccacatggtattttctgattgtgctccctgtcttgctagtgattgtcattttt
gcggccgtgggggtgaccaggcacaaatcgaaggagctgagtcgcaaacagagtcaacaa
ctagaattgctggaaagcgagctccggaaagagatacgtgacggctttgctgagctgcag
atggataaattggatgtggttgatagttttggaactgttcccttccttgactacaaacat
tttgctctgagaactttcttccctgagtcaggtggcttcacccacatcttcactgaagat
atgcataacagagacgccaacgacaagaatgaaagtctcacagctttggatgccctaatc
tgtaataaaagctttcttgttactgtcatccacacccttgaaaagcagaagaacttttct
gtgaaggacaggtgtctgtttgcctccttcctaaccattgcactgcaaaccaagctggtc
tacctgaccagcatcctagaggtgctgaccagggacttgatggaacagtgtagtaacatg
cagccgaaactcatgctgagacgcacggagtccgtcgtcgaaaaactcctcacaaactgg
atgtccgtctgcctttctggatttctccgggagactgtcggagagcccttctatttgctg
gtgacgactctgaaccagaaaattaacaagggtcccgtggatgtaatcacttgcaaagcc
ctgtacacacttaatgaagactggctgttgtggcaggttccggaattcagtactgtggca
ttaaacgtcgtctttgaaaaaatcccggaaaacgagagtgcagatgtctgtcggaatatt
tcagtcaatgttctcgactgtgacaccattggccaagccaaagaaaagattttccaagca
ttcttaagcaaaaatggctctccttatggacttcagcttaatgaaattggtcttgagctt
caaatgggcacacgacagaaagaacttctggacatcgacagttcctccgtgattcttgaa
gatggaatcaccaagctaaacaccattggccactatgagatatcaaatggatccactata
aaagtctttaagaagatagcaaattttacttcagatgtggagtactcggatgaccactgc
catttgattttaccagattcggaagcattccaagatgtgcaaggaaagagacatcgaggg
aagcacaagttcaaagtaaaagaaatgtatctgacaaagctgctgtcgaccaaggtggca
attcattctgtgcttgaaaaactttttagaagcatttggagtttacccaacagcagagct
ccatttgctataaaatacttttttgactttttggacgcccaggctgaaaacaaaaaaatc
acagatcctgacgtcgtacatatttggaaaacaaacagccttcctcttcgcttctgggta
aacatcctgaagaaccctcagtttgtctttgacattaagaagacaccacatatagacggc
tgtttgtcagtgattgcccaggcattcatggatgcattttctctcacagagcagcaacta
gggaaggaagcaccaactaataagcttctctatgccaaggatatcccaacctacaaagaa
gaagtaaaatcttattacaaagcaatcagggatttgcctccattgtcatcctcagaaatg
gaagaatttttaactcaggaatctaagaaacatgaaaatgaatttaatgaagaagtggcc
ttgacagaaatttacaaatacatcgtaaaatattttgatgagattctaaataaactagaa
agagaacgagggctggaagaagctcagaaacaactcttgcatgtaaaagtcttatttgat
gaaaagaagaaatgcaagtggatgtaa

Protein Sequence

>10154 : length: 1568
MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVA
SGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAGLG
GLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVA
ATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLW
NGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHPDGRRLLLSSSLV
EALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQP
ERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIK
EETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQR
CTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVD
SSRELCQNKSQPNRTCTCSIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPA
CVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQ
VFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMK
FSLPSSRKEMKDVCIQFDGGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFD
VIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRVQDTYLDCGTLQY
REDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQ
DLTTILCKIKGIKTASTIANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIF
AAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKH
FALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFS
VKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNW
MSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVA
LNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLEL
QMGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHC
HLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRA
PFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDG
CLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEM
EEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFD
EKKKCKWM



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