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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 10154 |
Name | PLXNC1 |
Synonym | CD232|PLXN-C1|VESPR;plexin C1;PLXNC1;plexin C1 |
Definition | plexin (semaphorin receptor)|plexin-C1|receptor for viral semaphorin protein|receptor for virally-encoded semaphorin|virus-encoded semaphorin protein receptor |
Position | 12q23.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma". |
potential | "Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression." |
| More detail of all 2 literatures about PLXNC1 | |
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Pathways and Diseases |
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Pathway | Other semaphorin interactions;PID Reactome;500078 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Disease | Melanoma;FunDO |
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External Links |
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Links to Entrez Gene | 10154 |
Links to all GeneRIF Items | 10154 |
Links to iHOP | 10154 |
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Sequence Information |
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Nucleotide Sequence |
>10154 : length: 4707 atggaggtctcccggaggaaggcgccgccgcgccccccgcgccccgcagcgccactgccc ctgctcgcctatctgctggcactggcggctcccggccggggcgcggacgagcccgtgtgg cggtcggagcaagccatcggagccatcgcggcgagccaggaggacggcgtgtttgtggcg agcggcagctgcctggaccagctggactacagcctggagcacagcctctcgcgcctgtac cgggaccaagcgggcaactgcacagagccggtctcgctggcgccccccgcgcggccccgg cccgggagcagcttcagcaagctgctgctgccctaccgcgagggggcggccggcctcggg gggctgctgctcaccggctggaccttcgaccggggcgcctgcgaggtgcggcccctgggc aacctgagccgcaactccctgcgcaacggcaccgaggtggtgtcgtgccacccgcagggc tcgacggccggcgtggtgtaccgcgcgggccggaacaaccgctggtacctggcggtggcc gccacctacgtgctgcctgagccggagacggcgagccgctgcaaccccgcggcatccgac cacgacacggccatcgcgctcaaggacacggaggggcgcagcctggccacgcaggagctg gggcgcctcaagctgtgcgagggcgcgggcagcctgcacttcgtggacgcctttctctgg aacggcagcatctacttcccctactacccctacaactacacgagcggcgctgccaccggc tggcccagcatggcgcgcatcgcgcagagcaccgaggtgctgttccagggccaggcatcc ctcgactgcggccacggccaccccgacggccgccgcctgctcctctcctccagcctagtg gaggccctggacgtctgggcgggagtgttcagcgcggccgctggagagggccaggagcgg cgctcccccaccaccacggcgctctgcctcttcagaatgagtgagatccaggcgcgcgcc aagagggtcagctgggacttcaagacggccgagagccactgcaaagaaggggatcaacct gaaagagtccaaccaatcgcatcatctaccttgatccattccgacctgacatccgtttat ggcaccgtggtaatgaacaggactgttttattcttggggactggagatggccagttactt aaggttattcttggtgagaatttgacttcaaattgtccagaggttatctatgaaattaaa gaagagacacctgttttctacaaactcgttcctgatcctgtgaagaatatctacatttat ctaacagctgggaaagaggtgaggagaattcgtgttgcaaactgcaataaacataaatcc tgttcggagtgtttaacagccacagaccctcactgcggttggtgccattcgctacaaagg tgcacttttcaaggagattgtgtacattcagagaacttagaaaactggctggatatttcg tctggagcaaaaaagtgccctaaaattcagataattcgaagcagtaaagaaaagactaca gtgactatggtgggaagcttctctccaagacactcaaagtgcatggtgaagaatgtggac tctagcagggagctctgccagaataaaagtcagcccaaccggacctgcacctgtagcatc ccaaccagagcaacctacaaagatgtttcagttgtcaacgtgatgttctccttcggttct tggaatttatcagacagattcaactttaccaactgctcatcattaaaagaatgcccagca tgcgtagaaactggctgcgcgtggtgtaaaagtgcaagaaggtgtatccaccccttcaca gcttgcgacccttctgattatgagagaaaccaggaacagtgtccagtggctgtcgagaag acatcaggaggaggaagacccaaggagaacaaggggaacagaaccaaccaggctttacag gtcttctacattaagtccattgagccacagaaagtatcgacattagggaaaagcaacgtg atagtaacgggagcaaactttacccgggcatcgaacatcacaatgatcctgaaaggaacc agtacctgtgataaggatgtgatacaggttagccatgtgctaaatgacacccacatgaaa ttctctcttccatcaagccggaaagaaatgaaggatgtgtgtatccagtttgatggtggg aactgctcttctgtgggatccttatcctacattgctctgccacattgttcccttatattt cctgctaccacctggatcagtggtggtcaaaatataaccatgatgggcagaaattttgat gtaattgacaacttaatcatttcacatgaattaaaaggaaacataaatgtctctgaatat tgtgtggcgacttactgcgggtttttagcccccagtttaaagagttcaaaagtgcgcacg aatgtcactgtgaagctgagagtacaagacacctacttggattgtggaaccctgcagtat cgggaggaccccagattcacggggtatcgggtggaatccgaggtggacacagaactggaa gtgaaaattcaaaaagaaaatgacaacttcaacatttccaaaaaagacattgaaattact ctcttccatggggaaaatgggcaattaaattgcagttttgaaaatattactagaaatcaa gatcttaccaccatcctttgcaaaattaaaggcatcaagactgcaagcaccattgccaac tcttctaagaaagttcgggtcaagctgggaaacctggagctctacgtcgagcaggagtca gttccttccacatggtattttctgattgtgctccctgtcttgctagtgattgtcattttt gcggccgtgggggtgaccaggcacaaatcgaaggagctgagtcgcaaacagagtcaacaa ctagaattgctggaaagcgagctccggaaagagatacgtgacggctttgctgagctgcag atggataaattggatgtggttgatagttttggaactgttcccttccttgactacaaacat tttgctctgagaactttcttccctgagtcaggtggcttcacccacatcttcactgaagat atgcataacagagacgccaacgacaagaatgaaagtctcacagctttggatgccctaatc tgtaataaaagctttcttgttactgtcatccacacccttgaaaagcagaagaacttttct gtgaaggacaggtgtctgtttgcctccttcctaaccattgcactgcaaaccaagctggtc tacctgaccagcatcctagaggtgctgaccagggacttgatggaacagtgtagtaacatg cagccgaaactcatgctgagacgcacggagtccgtcgtcgaaaaactcctcacaaactgg atgtccgtctgcctttctggatttctccgggagactgtcggagagcccttctatttgctg gtgacgactctgaaccagaaaattaacaagggtcccgtggatgtaatcacttgcaaagcc ctgtacacacttaatgaagactggctgttgtggcaggttccggaattcagtactgtggca ttaaacgtcgtctttgaaaaaatcccggaaaacgagagtgcagatgtctgtcggaatatt tcagtcaatgttctcgactgtgacaccattggccaagccaaagaaaagattttccaagca ttcttaagcaaaaatggctctccttatggacttcagcttaatgaaattggtcttgagctt caaatgggcacacgacagaaagaacttctggacatcgacagttcctccgtgattcttgaa gatggaatcaccaagctaaacaccattggccactatgagatatcaaatggatccactata aaagtctttaagaagatagcaaattttacttcagatgtggagtactcggatgaccactgc catttgattttaccagattcggaagcattccaagatgtgcaaggaaagagacatcgaggg aagcacaagttcaaagtaaaagaaatgtatctgacaaagctgctgtcgaccaaggtggca attcattctgtgcttgaaaaactttttagaagcatttggagtttacccaacagcagagct ccatttgctataaaatacttttttgactttttggacgcccaggctgaaaacaaaaaaatc acagatcctgacgtcgtacatatttggaaaacaaacagccttcctcttcgcttctgggta aacatcctgaagaaccctcagtttgtctttgacattaagaagacaccacatatagacggc tgtttgtcagtgattgcccaggcattcatggatgcattttctctcacagagcagcaacta gggaaggaagcaccaactaataagcttctctatgccaaggatatcccaacctacaaagaa gaagtaaaatcttattacaaagcaatcagggatttgcctccattgtcatcctcagaaatg gaagaatttttaactcaggaatctaagaaacatgaaaatgaatttaatgaagaagtggcc ttgacagaaatttacaaatacatcgtaaaatattttgatgagattctaaataaactagaa agagaacgagggctggaagaagctcagaaacaactcttgcatgtaaaagtcttatttgat gaaaagaagaaatgcaagtggatgtaa |
Protein Sequence |
>10154 : length: 1568 MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVA SGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAGLG GLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVA ATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLW NGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHPDGRRLLLSSSLV EALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQP ERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIK EETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQR CTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVD SSRELCQNKSQPNRTCTCSIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPA CVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQ VFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMK FSLPSSRKEMKDVCIQFDGGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFD VIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRVQDTYLDCGTLQY REDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQ DLTTILCKIKGIKTASTIANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIF AAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKH FALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFS VKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNW MSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVA LNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLEL QMGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHC HLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRA PFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDG CLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEM EEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFD EKKKCKWM |