|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 10277 |
Name | UBE4B |
Synonym | E4|HDNB1|UBOX3|UFD2|UFD2A;ubiquitination factor E4B;UBE4B;ubiquitination factor E4B |
Definition | UFD2A-III/UBE4B-III splice isoform|homologous to yeast UFD2|homozygously deleted in neuroblastoma 1|homozygously deleted in neuroblastoma-1|ubiquitin conjugation factor E4 B|ubiquitin fusion degradation protein 2|ubiquitin-fusion degradation protein 2|ubi |
Position | 1p36.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
|
Evidence Status |
Description |
potential | A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL tumor suppressor gene in the region at this stage. |
| More detail of all 1 literatures about UBE4B | |
|
Pathways and Diseases |
|
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
|
External Links |
|
Links to Entrez Gene | 10277 |
Links to all GeneRIF Items | 10277 |
Links to iHOP | 10277 |
|
Sequence Information |
|
Nucleotide Sequence |
>10277 : length: 3909 atggaggagctgagcgctgatgagattcgacggaggcgccttgcacgacttgctggtgga cagacctctcagccaaccaccccactcacctctccccagagggagaaccctccggggcct cccatagcggcatcagccccaggaccctctcagagtcttggtctcaatgtccacaacatg accccagctacctccccaataggtgcatcaggagtagcccatcgaagccagagcagtgaa ggagtcagttctctcagcagctcgccctctaatagccttgaaacgcaatctcagtctctc tcacgttcccagagcatggatatcgatggtgtctcatgtgagaaaagcatgtcccaggtg gatgtggattcaggaattgaaaacatggaggttgatgaaaatgatcgaagagaaaagcgg agcctcagtgataaggagccttcctcgggccctgaagtgtctgaagagcaggccttacag ctggtctgtaagatcttccgtgtctcttggaaggaccgggacagagatgtcatctttctt tcttctctttctgcacagtttaagcagaacccaaaagaagtattctccgattttaaggac ttgattggccagattttaatggaagtgctaatgatgtccactcagaccagagatgaaaac ccatttgccagtctgacagccacatcacagccaattgctgcagcagcacggtcaccagac agaaatctcttgctaaacactggctccaatccaggaacaagccccatgttctgcagcgtg gcttcctttggtgccagctctttgtctagcctctatgaaagtagtccggctcccactccc agtttctggagctctgttcccgtgatgggcccgtctcttgcctcaccttcccgtgcagcc agccagttggctgtgccttccactcccctcagtcctcacagtgcagcctctggaactgct gcgggaagccagccttcatccccgcggtatcgcccctacactgtcactcacccatgggcg tcctcaggcgtctccattctgtcgagctccccaagtccccctgccctcgccagtagcccc caagcagtgcccgccagcagttccagacagaggcccagcagcacgggtccacccctacca cccgcctcacccagtgccacgagcagacgcccctcctccctgaggatctctcctagtttg ggagcctctggtggagcaagtaattgggattcctacagtgaccatttcaccattgaaacc tgcaaagagacagatatgctgaactacctcatcgagtgtttcgaccgagttggaatagag gaaaaaaaagcaccaaagatgtgcagccagccagcagtcagccagcttctgagcaacatc cgctcacagtgcatatcccatactgctttagtactacaaggctccctaacacagcccagg tccttgcagcagccgtccttcctagtgccgtatatgctgtgtaggaatctcccatatggc ttcattcaggaactggtgagaaccactcaccaggatgaagaagtgttcaagcagatattt atccccattttacaaggcctggctcttgctgccaaagagtgctccctcgacagtgactac tttaaataccccctcatggcactaggtgagctctgtgaaaccaagtttgggaagacacac cctgtgtgcaatttggttgcttctttgcggttgtggttgccgaaatccttaagtcctggc tgtgggcgggagctgcagagactctcttacttaggggctttctttagcttctcagtcttt gcagaagatgatgttaaagtggttgaaaaatacttctcagggcctgccattaccctggaa aacactcgtgtggttagccaatcattgcagcattacttagagctcggaaggcaagagctt tttaagattctgcatagtattttgttaaatggcgaaacccgtgaggctgctctcagttac atggcggctgtcgtcaatgccaatatgaagaaagcacagatgcagacagatgatagattg gtgtctacagatggatttatgctgaatttcctttgggtactgcagcagctaagtacaaaa atcaagttagaaacagttgatcccacgtatatttttcacccaagatgtcggattactctt cccaatgatgagacgcgtgtgaatgcaacgatggaagatgtgaatgactggctgactgaa ctctatggcgatcagcctccattttctgagccgaaattccctacggagtgcttctttctc accctgcatgctcaccacctctctattctgcctagttgccgtcgctatatccgcagactc cgggctatccgggagctcaatagaactgtagaagatttgaaaaataatgaaagccaatgg aaagattccccactggcaactagacaccgcgaaatgctgaagcgctgtaaaactcagctt aagaaactggtacggtgcaaggcctgtgctgatgctggcctacttgacgagagcttcctg agaagatgtctgaatttttatggccttctcattcagctgctgctccgcatcctggacccc gcatatcccgatataacactgcctttaaattcagatgtccccaaggtatttgcagcgttg cctgagttttatgtagaagatgttgcagaatttttattttttattgtacaatactctccc caggcgctttatgagccctgtactcaggatattgtgatgttccttgttgtgatgttgtgc aaccagaactacatccgaaacccatatttggtggccaaactggtagaagtcatgtttatg accaaccctgctgttcagccacgaacccagaagttttttgaaatgattgagaaccatcct ctctccaccaagttgttggtaccttccctgatgaagttttatacagatgttgagcatacc ggagccaccagtgagttttatgacaagttcacaattcgctatcatattagcaccattttt aaaagcctttggcaaaacatagctcaccatggcacctttatggaggagttcaactccggg aagcagtttgttcgctatataaacatgttgataaacgacacgacgtttttgctcgatgaa agtctggagtctctgaagcgaatccatgaagtgcaggaagagatgaagaacaaagaacag tgggaccagttgccccgggatcagcagcaggctcgtcagtctcagcttgctcaggatgag cgtgtgtcccgctcttacctcgccctggccaccgaaaccgtggacatgttccacatcctc acgaagcaggtccagaagcccttcctcagaccggagcttggaccccgattggctgcaatg ctgaactttaatcttcagcaactttgtggccccaagtgccgtgacctgaaagttgaaaac cctgagaaatacggctttgaaccaaagaagctgttggaccaactgacggatatttactta cagctggactgtgctcggttcgcgaaagccattgctgacgaccagagatcctacagtaag gaattgtttgaagaagttatttcaaagatgcggaaggcagggatcaaatccacaatagca atagaaaaatttaagctgctcgccgagaaagtggaggagatagtggccaagaacgcacgc gcagaaatcgactacagcgacgctcctgatgagttcagagaccctctgatggacaccctc atgacagaccccgtgcggctgccctctggcaccatcatggaccgctccatcatcctgcgg cacctgctcaactcccccacggaccccttcaaccggcagacgctgacagagagcatgctg gaaccagtgccagaactgaaagagcagattcaggcgtggatgagagagaaacagaacagc gatcactaa |
Protein Sequence |
>10277 : length: 1302 MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNM TPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQV DVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFL SSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPD RNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAA SQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSP QAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIET CKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPR SLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDY FKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVF AEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSY MAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITL PNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRL RAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFL RRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSP QALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHP LSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSG KQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDE RVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVEN PEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIA IEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILR HLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH |