Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

10277

Name

UBE4B

Synonym

E4|HDNB1|UBOX3|UFD2|UFD2A;ubiquitination factor E4B;UBE4B;ubiquitination factor E4B

Definition

UFD2A-III/UBE4B-III splice isoform|homologous to yeast UFD2|homozygously deleted in neuroblastoma 1|homozygously deleted in neuroblastoma-1|ubiquitin conjugation factor E4 B|ubiquitin fusion degradation protein 2|ubiquitin-fusion degradation protein 2|ubi

Position

1p36.3

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL tumor suppressor gene in the region at this stage.
More detail of all 1 literatures about UBE4B

Pathways and Diseases

Pathway

Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141

Pathway

Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120

External Links

Links to Entrez Gene

10277

Links to all GeneRIF Items

10277

Links to iHOP

10277

Sequence Information

Nucleotide Sequence

>10277 : length: 3909
atggaggagctgagcgctgatgagattcgacggaggcgccttgcacgacttgctggtgga
cagacctctcagccaaccaccccactcacctctccccagagggagaaccctccggggcct
cccatagcggcatcagccccaggaccctctcagagtcttggtctcaatgtccacaacatg
accccagctacctccccaataggtgcatcaggagtagcccatcgaagccagagcagtgaa
ggagtcagttctctcagcagctcgccctctaatagccttgaaacgcaatctcagtctctc
tcacgttcccagagcatggatatcgatggtgtctcatgtgagaaaagcatgtcccaggtg
gatgtggattcaggaattgaaaacatggaggttgatgaaaatgatcgaagagaaaagcgg
agcctcagtgataaggagccttcctcgggccctgaagtgtctgaagagcaggccttacag
ctggtctgtaagatcttccgtgtctcttggaaggaccgggacagagatgtcatctttctt
tcttctctttctgcacagtttaagcagaacccaaaagaagtattctccgattttaaggac
ttgattggccagattttaatggaagtgctaatgatgtccactcagaccagagatgaaaac
ccatttgccagtctgacagccacatcacagccaattgctgcagcagcacggtcaccagac
agaaatctcttgctaaacactggctccaatccaggaacaagccccatgttctgcagcgtg
gcttcctttggtgccagctctttgtctagcctctatgaaagtagtccggctcccactccc
agtttctggagctctgttcccgtgatgggcccgtctcttgcctcaccttcccgtgcagcc
agccagttggctgtgccttccactcccctcagtcctcacagtgcagcctctggaactgct
gcgggaagccagccttcatccccgcggtatcgcccctacactgtcactcacccatgggcg
tcctcaggcgtctccattctgtcgagctccccaagtccccctgccctcgccagtagcccc
caagcagtgcccgccagcagttccagacagaggcccagcagcacgggtccacccctacca
cccgcctcacccagtgccacgagcagacgcccctcctccctgaggatctctcctagtttg
ggagcctctggtggagcaagtaattgggattcctacagtgaccatttcaccattgaaacc
tgcaaagagacagatatgctgaactacctcatcgagtgtttcgaccgagttggaatagag
gaaaaaaaagcaccaaagatgtgcagccagccagcagtcagccagcttctgagcaacatc
cgctcacagtgcatatcccatactgctttagtactacaaggctccctaacacagcccagg
tccttgcagcagccgtccttcctagtgccgtatatgctgtgtaggaatctcccatatggc
ttcattcaggaactggtgagaaccactcaccaggatgaagaagtgttcaagcagatattt
atccccattttacaaggcctggctcttgctgccaaagagtgctccctcgacagtgactac
tttaaataccccctcatggcactaggtgagctctgtgaaaccaagtttgggaagacacac
cctgtgtgcaatttggttgcttctttgcggttgtggttgccgaaatccttaagtcctggc
tgtgggcgggagctgcagagactctcttacttaggggctttctttagcttctcagtcttt
gcagaagatgatgttaaagtggttgaaaaatacttctcagggcctgccattaccctggaa
aacactcgtgtggttagccaatcattgcagcattacttagagctcggaaggcaagagctt
tttaagattctgcatagtattttgttaaatggcgaaacccgtgaggctgctctcagttac
atggcggctgtcgtcaatgccaatatgaagaaagcacagatgcagacagatgatagattg
gtgtctacagatggatttatgctgaatttcctttgggtactgcagcagctaagtacaaaa
atcaagttagaaacagttgatcccacgtatatttttcacccaagatgtcggattactctt
cccaatgatgagacgcgtgtgaatgcaacgatggaagatgtgaatgactggctgactgaa
ctctatggcgatcagcctccattttctgagccgaaattccctacggagtgcttctttctc
accctgcatgctcaccacctctctattctgcctagttgccgtcgctatatccgcagactc
cgggctatccgggagctcaatagaactgtagaagatttgaaaaataatgaaagccaatgg
aaagattccccactggcaactagacaccgcgaaatgctgaagcgctgtaaaactcagctt
aagaaactggtacggtgcaaggcctgtgctgatgctggcctacttgacgagagcttcctg
agaagatgtctgaatttttatggccttctcattcagctgctgctccgcatcctggacccc
gcatatcccgatataacactgcctttaaattcagatgtccccaaggtatttgcagcgttg
cctgagttttatgtagaagatgttgcagaatttttattttttattgtacaatactctccc
caggcgctttatgagccctgtactcaggatattgtgatgttccttgttgtgatgttgtgc
aaccagaactacatccgaaacccatatttggtggccaaactggtagaagtcatgtttatg
accaaccctgctgttcagccacgaacccagaagttttttgaaatgattgagaaccatcct
ctctccaccaagttgttggtaccttccctgatgaagttttatacagatgttgagcatacc
ggagccaccagtgagttttatgacaagttcacaattcgctatcatattagcaccattttt
aaaagcctttggcaaaacatagctcaccatggcacctttatggaggagttcaactccggg
aagcagtttgttcgctatataaacatgttgataaacgacacgacgtttttgctcgatgaa
agtctggagtctctgaagcgaatccatgaagtgcaggaagagatgaagaacaaagaacag
tgggaccagttgccccgggatcagcagcaggctcgtcagtctcagcttgctcaggatgag
cgtgtgtcccgctcttacctcgccctggccaccgaaaccgtggacatgttccacatcctc
acgaagcaggtccagaagcccttcctcagaccggagcttggaccccgattggctgcaatg
ctgaactttaatcttcagcaactttgtggccccaagtgccgtgacctgaaagttgaaaac
cctgagaaatacggctttgaaccaaagaagctgttggaccaactgacggatatttactta
cagctggactgtgctcggttcgcgaaagccattgctgacgaccagagatcctacagtaag
gaattgtttgaagaagttatttcaaagatgcggaaggcagggatcaaatccacaatagca
atagaaaaatttaagctgctcgccgagaaagtggaggagatagtggccaagaacgcacgc
gcagaaatcgactacagcgacgctcctgatgagttcagagaccctctgatggacaccctc
atgacagaccccgtgcggctgccctctggcaccatcatggaccgctccatcatcctgcgg
cacctgctcaactcccccacggaccccttcaaccggcagacgctgacagagagcatgctg
gaaccagtgccagaactgaaagagcagattcaggcgtggatgagagagaaacagaacagc
gatcactaa

Protein Sequence

>10277 : length: 1302
MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNM
TPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQV
DVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFL
SSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIAAAARSPD
RNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAA
SQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYTVTHPWASSGVSILSSSPSPPALASSP
QAVPASSSRQRPSSTGPPLPPASPSATSRRPSSLRISPSLGASGGASNWDSYSDHFTIET
CKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPR
SLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLDSDY
FKYPLMALGELCETKFGKTHPVCNLVASLRLWLPKSLSPGCGRELQRLSYLGAFFSFSVF
AEDDVKVVEKYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSY
MAAVVNANMKKAQMQTDDRLVSTDGFMLNFLWVLQQLSTKIKLETVDPTYIFHPRCRITL
PNDETRVNATMEDVNDWLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRL
RAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFL
RRCLNFYGLLIQLLLRILDPAYPDITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSP
QALYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHP
LSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSG
KQFVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDE
RVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVEN
PEKYGFEPKKLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIA
IEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILR
HLLNSPTDPFNRQTLTESMLEPVPELKEQIQAWMREKQNSDH



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