Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

1028

Name

CDKN1C

Synonym

BWCR|BWS|KIP2|WBS|p57;cyclin-dependent kinase inhibitor 1C (p57, Kip2);CDKN1C;cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Definition

cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor p57|p57Kip2

Position

11p15.5

Gene Type

protein-coding

Source

Count: 4; Pubmed_search,TAG,Generif,UniProt

Literature support

Count: 5 PubMed records as below.

Evidence Status

Description

potential

"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene."

reviewed

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.

reviewed

The expression of CDKN1C decreases in the large majority of breast cancers and does not appear to be mediated by AI/LOH at the gene. CDKN1C may be a breast cancer tumor suppressor.

reviewed

Differential tumor suppressor properties and transforming growth factor-beta responsiveness of p57KIP2 in leukemia cells with aberrant p57KIP2 promoter DNA methylation.

reviewed

Compensation by tumor suppressor genes during retinal development in mice and humans.
More detail of all 5 literatures about CDKN1C

Pathways and Diseases

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Disease

Cancers;KEGG DISEASE

Disease

Ovarian disease;FunDO

Disease

Adrenal carcinoma;KEGG DISEASE;H00033

Disease

CARDIOVASCULAR;GAD

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

atherosclerosis, generalized myocardial infarct;GAD

Disease

Congenital abnormality;FunDO

Disease

Cancer;FunDO

Disease

Beckwith-Wiedemann syndrome;OMIM

Disease

Placenta disease;FunDO

Disease

Atherosclerosis;FunDO

External Links

Links to Entrez Gene

1028

Links to all GeneRIF Items

1028

Links to iHOP

1028

Sequence Information

Nucleotide Sequence

>1028 : length: 951
atgtccgacgcgtccctccgcagcacatccacgatggagcgtcttgtcgcccgtgggacc
ttcccagtactagtgcgcaccagcgcctgccgcagcctcttcgggccggtggaccacgag
gagctgagccgcgagctgcaggcccgcctggccgagctgaacgccgaggaccagaaccgc
tgggattacgacttccagcaggacatgccgctgcggggccctggacgcctgcagtggacc
gaagtggacagcgactcggtgcccgcgttctaccgcgagacggtgcaggtggggcgctgc
cgcctgctgctggcgccgcggcccgtcgcggtcgcggtggctgtcagcccgcccctcgag
ccggccgctgagtccctcgacggcctcgaggaggcgccggagcagctgcctagtgtcccg
gtcccggccccggcgtccaccccgcccccagtcccggtcctggctccagccccggccccg
gctccggctccggtcgcggctccggtcgcggctccggtcgcggtcgcggtcctggccccg
gccccggccccggctccggctccggctccggccccggctccagtcgcggccccggcccca
gccccggccccggccccggccccggcccccgccccggccccggccccggacgcggcgcct
caagagagcgccgagcagggcgcgaaccaggggcagcgcggccaggagcctctcgctgac
cagctgcactcggggatttcgggacgtcccgcggccggcaccgcggccgccagcgccaac
ggcgcggcgatcaagaagctgtccgggcctctgatctccgatttcttcgccaagcgcaag
agatcagcgcctgagaagtcgtcgggcgatgtccccgcgccgtgtccctctccaagcgcc
gcccctggcgtgggctcggtggagcagaccccgcgcaagaggctgcggtga

Protein Sequence

>1028 : length: 316
MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNR
WDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPPLE
PAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAP
APAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLAD
QLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSA
APGVGSVEQTPRKRLR



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