Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

10395

Name

DLC1

Synonym

ARHGAP7|HP|STARD12|p122-RhoGAP;deleted in liver cancer 1;DLC1;deleted in liver cancer 1

Definition

Rho-GTPase-activating protein 7|START domain-containing protein 12|StAR-related lipid transfer (START) domain containing 12|deleted in liver cancer 1 protein|deleted in liver cancer 1 variant 2|rho GTPase-activating protein 7|rho-type GTPase-activating pr

Position

8p22

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,TAG,Generif

Literature support

Count: 23 PubMed records as below.

Evidence Status

Description

reviewed

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).

reviewed

A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.

reviewed

The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

reviewed

MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes.

reviewed

DLC-1 may play an important role in lymphoma by acting as a bona fide new tumor suppressor gene.

reviewed

Phosphorylation of DLC1 and DLC2 by protein kinase B at the conserved residue points to a common regulatory mechanism of the DLC tumor suppressor family.

reviewed

Phosphorylation of deleted in liver cancer 1 (DLC1) and DLC2 by Akt at the conserved residue points to a common regulatory mechanism of the DLC tumor suppressor family.

reviewed

"Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics."

reviewed

"Results confirm the role of DLC1 gene as a tumor suppressor, which may be manifested by regulation of p21 and cyclinDl."

reviewed

"Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility."
More detail of all 23 literatures about DLC1

Pathways and Diseases

Pathway

Signaling by Rho GTPases;Reactome;REACT:11044

Pathway

phospholipase c delta in phospholipid associated cell signaling;PID BioCarta;100071

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

Regulation of RhoA activity;PID Curated;200050

Disease

Cancer;FunDO

Disease

Colorectal cancer, somatic;OMIM

External Links

Links to Entrez Gene

10395

Links to all GeneRIF Items

10395

Links to iHOP

10395

Sequence Information

Nucleotide Sequence

>10395 : length: 3054
atgaagctagaaattagtcctcatcggaaacgaagtgacgattcagacgaggatgagcct
tgtgccatcagtggcaaatggactttccaaagggacagcaagaggtggtcccggcttgaa
gagtttgatgtcttttctccaaaacaagacctggtccctgggtccccagacgactcccac
ccgaaggacggccccagccccggaggcacgctgatggacctcagcgagcgccaggaggtg
tcttccgtccgcagcctcagcagcactggcagcctccccagccacgcgccccccagcgag
gatgctgccaccccccggactaactccgtcatcagcgtttgctcctccagcaacttggca
ggcaatgacgactctttcggcagcctgccctctcccaaggaactgtccagcttcagcttc
agcatgaaaggccacgaaaaaactgccaagtccaagacgcgcagtctgctgaaacggatg
gagagcctgaagctcaagagctcccatcacagcaagcacaaagcgccctcaaagctgggg
ttgatcatcagcgggcccatcttgcaagaggggatggatgaggagaagctgaagcagctc
aactgcgtggagatctccgccctcaatggcaaccgcatcaacgtccccatggtacgaaag
aggagcgtttccaactccacgcagaccagcagcagcagcagccagtcggagaccagcagc
gcggtcagcacgcccagccctgttacgaggacccggagcctcagtgcgtgcaacaagcgg
gtgggcatgtacttagagggcttcgatcctttcaatcagtcaacatttaacaacgtggtg
gagcagaactttaagaaccgcgagagctacccagaggacacggtgttctacatccctgaa
gatcacaagcctggcactttccccaaagctctcaccaatggcagtttctccccctcgggg
aataacggctctgtgaactggaggacgggaagcttccacggccctggccacatcagcctc
aggagggaaaacagtagcgacagccccaaggaactgaagagacgcaattcttccagctcc
atgagcagccgcctgagcatctacgacaacgtgccgggctccatcctctactccagttca
ggggacctggcggatctggagaacgaggacatcttccccgagctggacgacatcctctac
cacgtgaaggggatgcagcggatagtcaatcagtggtcggagaagttttctgatgaggga
gattcggactcagccctggactcggtctctccctgcccgtcctctccaaaacagatacac
ctggatgtggacaacgaccgaaccacacccagcgacctggacagcacaggcaactccctg
aatgaaccggaagagccctccgagatcccggaaagaagggattctggggttggggcttcc
ctaaccaggtccaacaggcaccgactgagatggcacagtttccagagctcacatcggcca
agcctcaactctgtatcactacagattaactgccagtctgtggcccagatgaacctgctg
cagaaatactcactcctaaagctaacggccctgctggagaaatacacaccttctaacaag
catggttttagctgggccgtgcccaagttcatgaagaggatcaaggttccagactacaag
gaccggagtgtgtttggggtcccactgacggtcaacgtgcagcgcacaggacaaccgttg
cctcagagcatccagcaggccatgcgatacctccggaaccattgtttggatcaggttggg
ctcttcagaaaatcgggggtcaagtcccggattcaggctctgcgccagatgaatgaaggt
gccatagactgtgtcaactacgaaggacagtctgcttatgacgtggcagacatgctgaag
cagtattttcgagatcttcctgagccactaatgacgaacaaactctcggaaacctttcta
cagatctaccaatatgtgcccaaggaccagcgcctgcaggccatcaaggctgccatcatg
ctgctgcctgacgagaaccgggaggttctgcagaccctgctttatttcctgagcgatgtc
acagcagccgtaaaagaaaaccagatgaccccaaccaacctggccgtgtgcttagcgcct
tccctcttccatctcaacaccctgaagagagagaattcctctcccagggtaatgcaaaga
aaacaaagtttgggcaaaccagatcagaaagatttgaatgaaaacctagctgccactcaa
gggctggcccatatgatcgccgagtgcaagaagcttttccaggttcccgaggaaatgagc
cgatgtcgtaattcctataccgaacaagagctgaagcccctcactctggaagcactcggg
cacctgggtaatgatgactcagctgactaccaacacttcctccaggactgtgtggatggc
ctgtttaaagaagtcaaagagaagtttaaaggctgggtcagctactccacttcggagcag
gctgagctgtcctataagaaggtgagcgaaggaccccctctgaggctttggaggtcagtc
attgaagtccctgctgtgccagaggaaatcttaaagcgcctacttaaagaacagcacctc
tgggatgtagacctgttggattcaaaagtgatcgaaattctggacagccaaactgaaatt
taccagtatgtccaaaacagtatggcacctcatcctgctcgagactacgttgttttaaga
acctggaggactaatttacccaaaggagcctgtgcccttttactaacctctgtggatcac
gatcgcgcacctgtggtgggtgtgagggttaatgtgctcttgtccaggtatttgattgaa
ccctgtgggccaggaaaatccaaactcacctacatgtgcagagttgacttaaggggccac
atgccagaatggtacacaaaatcttttggacatttgtgtgcagctgaagttgtaaagatc
cgggattccttcagtaaccagaacactgaaaccaaagacaccaaatctaggtga

Protein Sequence

>10395 : length: 1017
MKLEISPHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSH
PKDGPSPGGTLMDLSERQEVSSVRSLSSTGSLPSHAPPSEDAATPRTNSVISVCSSSNLA
GNDDSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLG
LIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSS
AVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPE
DHKPGTFPKALTNGSFSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSS
MSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEG
DSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERRDSGVGAS
LTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNK
HGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVG
LFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFL
QIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAP
SLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMS
RCRNSYTEQELKPLTLEALGHLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYSTSEQ
AELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEI
YQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLSRYLIE
PCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQNTETKDTKSR



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