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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10395 |
Name | DLC1 |
Synonym | ARHGAP7|HP|STARD12|p122-RhoGAP;deleted in liver cancer 1;DLC1;deleted in liver cancer 1 |
Definition | Rho-GTPase-activating protein 7|START domain-containing protein 12|StAR-related lipid transfer (START) domain containing 12|deleted in liver cancer 1 protein|deleted in liver cancer 1 variant 2|rho GTPase-activating protein 7|rho-type GTPase-activating pr |
Position | 8p22 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 23 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK). |
reviewed | A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors. |
reviewed | The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. |
reviewed | MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes. |
reviewed | DLC-1 may play an important role in lymphoma by acting as a bona fide new tumor suppressor gene. |
reviewed | Phosphorylation of DLC1 and DLC2 by protein kinase B at the conserved residue points to a common regulatory mechanism of the DLC tumor suppressor family. |
reviewed | Phosphorylation of deleted in liver cancer 1 (DLC1) and DLC2 by Akt at the conserved residue points to a common regulatory mechanism of the DLC tumor suppressor family. |
reviewed | "Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics." |
reviewed | "Results confirm the role of DLC1 gene as a tumor suppressor, which may be manifested by regulation of p21 and cyclinDl." |
reviewed | "Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility." |
| More detail of all 23 literatures about DLC1 | |
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Pathways and Diseases |
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Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | phospholipase c delta in phospholipid associated cell signaling;PID BioCarta;100071 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Regulation of RhoA activity;PID Curated;200050 |
Disease | Cancer;FunDO |
Disease | Colorectal cancer, somatic;OMIM |
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External Links |
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Links to Entrez Gene | 10395 |
Links to all GeneRIF Items | 10395 |
Links to iHOP | 10395 |
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Sequence Information |
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Nucleotide Sequence |
>10395 : length: 3054 atgaagctagaaattagtcctcatcggaaacgaagtgacgattcagacgaggatgagcct tgtgccatcagtggcaaatggactttccaaagggacagcaagaggtggtcccggcttgaa gagtttgatgtcttttctccaaaacaagacctggtccctgggtccccagacgactcccac ccgaaggacggccccagccccggaggcacgctgatggacctcagcgagcgccaggaggtg tcttccgtccgcagcctcagcagcactggcagcctccccagccacgcgccccccagcgag gatgctgccaccccccggactaactccgtcatcagcgtttgctcctccagcaacttggca ggcaatgacgactctttcggcagcctgccctctcccaaggaactgtccagcttcagcttc agcatgaaaggccacgaaaaaactgccaagtccaagacgcgcagtctgctgaaacggatg gagagcctgaagctcaagagctcccatcacagcaagcacaaagcgccctcaaagctgggg ttgatcatcagcgggcccatcttgcaagaggggatggatgaggagaagctgaagcagctc aactgcgtggagatctccgccctcaatggcaaccgcatcaacgtccccatggtacgaaag aggagcgtttccaactccacgcagaccagcagcagcagcagccagtcggagaccagcagc gcggtcagcacgcccagccctgttacgaggacccggagcctcagtgcgtgcaacaagcgg gtgggcatgtacttagagggcttcgatcctttcaatcagtcaacatttaacaacgtggtg gagcagaactttaagaaccgcgagagctacccagaggacacggtgttctacatccctgaa gatcacaagcctggcactttccccaaagctctcaccaatggcagtttctccccctcgggg aataacggctctgtgaactggaggacgggaagcttccacggccctggccacatcagcctc aggagggaaaacagtagcgacagccccaaggaactgaagagacgcaattcttccagctcc atgagcagccgcctgagcatctacgacaacgtgccgggctccatcctctactccagttca ggggacctggcggatctggagaacgaggacatcttccccgagctggacgacatcctctac cacgtgaaggggatgcagcggatagtcaatcagtggtcggagaagttttctgatgaggga gattcggactcagccctggactcggtctctccctgcccgtcctctccaaaacagatacac ctggatgtggacaacgaccgaaccacacccagcgacctggacagcacaggcaactccctg aatgaaccggaagagccctccgagatcccggaaagaagggattctggggttggggcttcc ctaaccaggtccaacaggcaccgactgagatggcacagtttccagagctcacatcggcca agcctcaactctgtatcactacagattaactgccagtctgtggcccagatgaacctgctg cagaaatactcactcctaaagctaacggccctgctggagaaatacacaccttctaacaag catggttttagctgggccgtgcccaagttcatgaagaggatcaaggttccagactacaag gaccggagtgtgtttggggtcccactgacggtcaacgtgcagcgcacaggacaaccgttg cctcagagcatccagcaggccatgcgatacctccggaaccattgtttggatcaggttggg ctcttcagaaaatcgggggtcaagtcccggattcaggctctgcgccagatgaatgaaggt gccatagactgtgtcaactacgaaggacagtctgcttatgacgtggcagacatgctgaag cagtattttcgagatcttcctgagccactaatgacgaacaaactctcggaaacctttcta cagatctaccaatatgtgcccaaggaccagcgcctgcaggccatcaaggctgccatcatg ctgctgcctgacgagaaccgggaggttctgcagaccctgctttatttcctgagcgatgtc acagcagccgtaaaagaaaaccagatgaccccaaccaacctggccgtgtgcttagcgcct tccctcttccatctcaacaccctgaagagagagaattcctctcccagggtaatgcaaaga aaacaaagtttgggcaaaccagatcagaaagatttgaatgaaaacctagctgccactcaa gggctggcccatatgatcgccgagtgcaagaagcttttccaggttcccgaggaaatgagc cgatgtcgtaattcctataccgaacaagagctgaagcccctcactctggaagcactcggg cacctgggtaatgatgactcagctgactaccaacacttcctccaggactgtgtggatggc ctgtttaaagaagtcaaagagaagtttaaaggctgggtcagctactccacttcggagcag gctgagctgtcctataagaaggtgagcgaaggaccccctctgaggctttggaggtcagtc attgaagtccctgctgtgccagaggaaatcttaaagcgcctacttaaagaacagcacctc tgggatgtagacctgttggattcaaaagtgatcgaaattctggacagccaaactgaaatt taccagtatgtccaaaacagtatggcacctcatcctgctcgagactacgttgttttaaga acctggaggactaatttacccaaaggagcctgtgcccttttactaacctctgtggatcac gatcgcgcacctgtggtgggtgtgagggttaatgtgctcttgtccaggtatttgattgaa ccctgtgggccaggaaaatccaaactcacctacatgtgcagagttgacttaaggggccac atgccagaatggtacacaaaatcttttggacatttgtgtgcagctgaagttgtaaagatc cgggattccttcagtaaccagaacactgaaaccaaagacaccaaatctaggtga |
Protein Sequence |
>10395 : length: 1017 MKLEISPHRKRSDDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDLVPGSPDDSH PKDGPSPGGTLMDLSERQEVSSVRSLSSTGSLPSHAPPSEDAATPRTNSVISVCSSSNLA GNDDSFGSLPSPKELSSFSFSMKGHEKTAKSKTRSLLKRMESLKLKSSHHSKHKAPSKLG LIISGPILQEGMDEEKLKQLNCVEISALNGNRINVPMVRKRSVSNSTQTSSSSSQSETSS AVSTPSPVTRTRSLSACNKRVGMYLEGFDPFNQSTFNNVVEQNFKNRESYPEDTVFYIPE DHKPGTFPKALTNGSFSPSGNNGSVNWRTGSFHGPGHISLRRENSSDSPKELKRRNSSSS MSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEG DSDSALDSVSPCPSSPKQIHLDVDNDRTTPSDLDSTGNSLNEPEEPSEIPERRDSGVGAS LTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNK HGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVG LFRKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFL QIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAP SLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMS RCRNSYTEQELKPLTLEALGHLGNDDSADYQHFLQDCVDGLFKEVKEKFKGWVSYSTSEQ AELSYKKVSEGPPLRLWRSVIEVPAVPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEI YQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLSRYLIE PCGPGKSKLTYMCRVDLRGHMPEWYTKSFGHLCAAEVVKIRDSFSNQNTETKDTKSR |