Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

10413

Name

YAP1

Synonym

YAP|YAP2|YAP65|YKI;Yes-associated protein 1;YAP1;Yes-associated protein 1

Definition

65 kDa Yes-associated protein|yes-associated protein 2|yes-associated protein beta|yes-associated protein delta|yorkie homolog

Position

11q13

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 4 PubMed records as below.

Evidence Status

Description

reviewed

alphaE-catenin as a tumor suppressor that inhibits Yap1 activity and sequesters it in the cytoplasm.

reviewed

"YAP function as a tumor suppressor may alternatively be dysregulated by AKT phosphorylation at serine-127 and cytoplasmic sequestration, or by transcriptional repression by DeltaNp63, in different subsets of head and neck squamous cell carcinomas (HNSC.."

reviewed

"The existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene, is shown."

reviewed

"This is the first report indicating YAP as a tumor suppressor, revealing its decreased expression in breast cancer as well as demonstrating the functional implications of YAP loss in several aspects of cancer signaling."
More detail of all 4 literatures about YAP1

Pathways and Diseases

Pathway

TGF-beta receptor signaling;PID Curated;200195

Pathway

ErbB4 signaling events;PID Curated;200009

Disease

Cancer;FunDO

External Links

Links to Entrez Gene

10413

Links to all GeneRIF Items

10413

Links to iHOP

10413

Sequence Information

Nucleotide Sequence

>10413 : length: 1515
atggatcccgggcagcagccgccgcctcaaccggccccccagggccaagggcagccgcct
tcgcagcccccgcaggggcagggcccgccgtccggacccgggcaaccggcacccgcggcg
acccaggcggcgccgcaggcaccccccgccgggcatcagatcgtgcacgtccgcggggac
tcggagaccgacctggaggcgctcttcaacgccgtcatgaaccccaagacggccaacgtg
ccccagaccgtgcccatgaggctccggaagctgcccgactccttcttcaagccgccggag
cccaaatcccactcccgacaggccagtactgatgcaggcactgcaggagccctgactcca
cagcatgttcgagctcattcctctccagcttctctgcagttgggagctgtttctcctggg
acactgacccccactggagtagtctctggcccagcagctacacccacagctcagcatctt
cgacagtcttcttttgagatacctgatgatgtacctctgccagcaggttgggagatggca
aagacatcttctggtcagagatacttcttaaatcacatcgatcagacaacaacatggcag
gaccccaggaaggccatgctgtcccagatgaacgtcacagcccccaccagtccaccagtg
cagcagaatatgatgaactcggcttcaggtcctcttcctgatggatgggaacaagccatg
actcaggatggagaaatttactatataaaccataagaacaagaccacctcttggctagac
ccaaggcttgaccctcgttttgccatgaaccagagaatcagtcagagtgctccagtgaaa
cagccaccacccctggctccccagagcccacagggaggcgtcatgggtggcagcaactcc
aaccagcagcaacagatgcgactgcagcaactgcagatggagaaggagaggctgcggctg
aaacagcaagaactgcttcggcaggcaatgcggaatatcaatcccagcacagcaaattct
ccaaaatgtcaggagttagccctgcgtagccagttaccaacactggagcaggatggtggg
actcaaaatccagtgtcttctcccgggatgtctcaggaattgagaacaatgacgaccaat
agctcagatcctttccttaacagtggcacctatcactctcgagatgagagtacagacagt
ggactaagcatgagcagctacagtgtccctcgaaccccagatgacttcctgaacagtgtg
gatgagatggatacaggtgatactatcaaccaaagcaccctgccctcacagcagaaccgt
ttcccagactaccttgaagccattcctgggacaaatgtggaccttggaacactggaagga
gatggaatgaacatagaaggagaggagctgatgccaagtctgcaggaagctttgagttct
gacatccttaatgacatggagtctgttttggctgccaccaagctagataaagaaagcttt
cttacatggttatag

Protein Sequence

>10413 : length: 504
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD
SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP
QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS
NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG
TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV
DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS
DILNDMESVLAATKLDKESFLTWL



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