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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10413 |
Name | YAP1 |
Synonym | YAP|YAP2|YAP65|YKI;Yes-associated protein 1;YAP1;Yes-associated protein 1 |
Definition | 65 kDa Yes-associated protein|yes-associated protein 2|yes-associated protein beta|yes-associated protein delta|yorkie homolog |
Position | 11q13 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | alphaE-catenin as a tumor suppressor that inhibits Yap1 activity and sequesters it in the cytoplasm. |
reviewed | "YAP function as a tumor suppressor may alternatively be dysregulated by AKT phosphorylation at serine-127 and cytoplasmic sequestration, or by transcriptional repression by DeltaNp63, in different subsets of head and neck squamous cell carcinomas (HNSC.." |
reviewed | "The existence of a proapoptotic autoregulatory feedback loop between p73, YAP, and the promyelocytic leukemia (PML) tumor suppressor gene, is shown." |
reviewed | "This is the first report indicating YAP as a tumor suppressor, revealing its decreased expression in breast cancer as well as demonstrating the functional implications of YAP loss in several aspects of cancer signaling." |
| More detail of all 4 literatures about YAP1 | |
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Pathways and Diseases |
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Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Disease | Cancer;FunDO |
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External Links |
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Links to Entrez Gene | 10413 |
Links to all GeneRIF Items | 10413 |
Links to iHOP | 10413 |
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Sequence Information |
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Nucleotide Sequence |
>10413 : length: 1515 atggatcccgggcagcagccgccgcctcaaccggccccccagggccaagggcagccgcct tcgcagcccccgcaggggcagggcccgccgtccggacccgggcaaccggcacccgcggcg acccaggcggcgccgcaggcaccccccgccgggcatcagatcgtgcacgtccgcggggac tcggagaccgacctggaggcgctcttcaacgccgtcatgaaccccaagacggccaacgtg ccccagaccgtgcccatgaggctccggaagctgcccgactccttcttcaagccgccggag cccaaatcccactcccgacaggccagtactgatgcaggcactgcaggagccctgactcca cagcatgttcgagctcattcctctccagcttctctgcagttgggagctgtttctcctggg acactgacccccactggagtagtctctggcccagcagctacacccacagctcagcatctt cgacagtcttcttttgagatacctgatgatgtacctctgccagcaggttgggagatggca aagacatcttctggtcagagatacttcttaaatcacatcgatcagacaacaacatggcag gaccccaggaaggccatgctgtcccagatgaacgtcacagcccccaccagtccaccagtg cagcagaatatgatgaactcggcttcaggtcctcttcctgatggatgggaacaagccatg actcaggatggagaaatttactatataaaccataagaacaagaccacctcttggctagac ccaaggcttgaccctcgttttgccatgaaccagagaatcagtcagagtgctccagtgaaa cagccaccacccctggctccccagagcccacagggaggcgtcatgggtggcagcaactcc aaccagcagcaacagatgcgactgcagcaactgcagatggagaaggagaggctgcggctg aaacagcaagaactgcttcggcaggcaatgcggaatatcaatcccagcacagcaaattct ccaaaatgtcaggagttagccctgcgtagccagttaccaacactggagcaggatggtggg actcaaaatccagtgtcttctcccgggatgtctcaggaattgagaacaatgacgaccaat agctcagatcctttccttaacagtggcacctatcactctcgagatgagagtacagacagt ggactaagcatgagcagctacagtgtccctcgaaccccagatgacttcctgaacagtgtg gatgagatggatacaggtgatactatcaaccaaagcaccctgccctcacagcagaaccgt ttcccagactaccttgaagccattcctgggacaaatgtggaccttggaacactggaagga gatggaatgaacatagaaggagaggagctgatgccaagtctgcaggaagctttgagttct gacatccttaatgacatggagtctgttttggctgccaccaagctagataaagaaagcttt cttacatggttatag |
Protein Sequence |
>10413 : length: 504 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS DILNDMESVLAATKLDKESFLTWL |