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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10628 |
Name | TXNIP |
Synonym | EST01027|HHCPA78|THIF|VDUP1;thioredoxin interacting protein;TXNIP;thioredoxin interacting protein |
Definition | thioredoxin binding protein 2|thioredoxin-binding protein 2|thioredoxin-interacting protein|upregulated by 1,25-dihydroxyvitamin D-3|vitamin D3 up-regulated protein 1 |
Position | 1q21.1 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 4 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "In this study, we identify a known tumor suppressor gene, thioredoxin-interacting protein (Txnip) gene as a novel target of hnRNP G". |
reviewed | tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1. |
reviewed | "TXNIP (also named as VDUP-1 or TBP-2) was originally isolated in HL60 cells treated with Vitamin D3. Subsequently, it has been identified as a major redox regulator and a tumor suppressor Gene (TSG) in various solid tumors and hematological malignancies." |
reviewed | "The transformation associates the loss of thioredoxin-binding protein-2 (TBP-2), a tumor suppressor and regulator of lipid metabolism." |
| More detail of all 4 literatures about TXNIP | |
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External Links |
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Links to Entrez Gene | 10628 |
Links to all GeneRIF Items | 10628 |
Links to iHOP | 10628 |
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Sequence Information |
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Nucleotide Sequence |
>10628 : length: 1176 atggtgatgttcaagaagatcaagtcttttgaggtggtctttaacgaccctgaaaaggtg tacggcagtggcgagaaggtggctggccgggtgatagtggaggtgtgtgaagttactcgt gtcaaagccgttaggatcctggcttgcggagtggctaaagtgctttggatgcagggatcc cagcagtgcaaacagacttcggagtacctgcgctatgaagacacgcttcttctggaagac cagccaacaggtgagaatgagatggtgatcatgagacctggaaacaaatatgagtacaag ttcggctttgagcttcctcaggggcctctgggaacatccttcaaaggaaaatatgggtgt gtagactactgggtgaaggcttttcttgaccgcccgagccagccaactcaagagacaaag aaaaactttgaagtagtggatctggtggatgtcaatacccctgatttaatggcacctgtg tctgctaaaaaagaaaagaaagtttcctgcatgttcattcctgatgggcgggtgtctgtc tctgctcgaattgacagaaaaggattctgtgaaggtgatgagatttccatccatgctgac tttgagaatacatgttcccgaattgtggtccccaaagctgccattgtggcccgccacact taccttgccaatggccagaccaaggtgctgactcagaagttgtcatcagtcagaggcaat catattatctcagggacatgcgcatcatggcgtggcaagagccttcgggttcagaagatc aggccttctatcctgggctgcaacatccttcgagttgaatattccttactgatctatgtt agcgttcctggatccaagaaggtcatccttgacctgcccctggtaattggcagcagatca ggtctaagcagcagaacatccagcatggccagccgaaccagctctgagatgagttgggta gatctgaacatccctgataccccagaagctcctccctgctatatggatgtcattcctgaa gatcaccgattggagagcccaaccactcctctgctagatgacatggatggctctcaagac agccctatctttatgtatgcccctgagttcaagttcatgccaccaccgacttatactgag gtggatccctgcatcctcaacaacaatgtgcagtga |
Protein Sequence |
>10628 : length: 391 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ |