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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 10664 |
Name | CTCF |
Synonym | -;CCCTC-binding factor (zinc finger protein);CTCF;CCCTC-binding factor (zinc finger protein) |
Definition | 11 zinc finger transcriptional repressor|11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF |
Position | 16q21-q22.3 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Results substantiate the critical role of CTCF in establishing and maintaining p16INK4A and other tumor suppressor genes in higher-order chromosomal domains through appropriate boundary formation. |
reviewed | "observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific ""change of function"" rather than complete ""loss of function""". |
| More detail of all 2 literatures about CTCF | |
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Pathways and Diseases |
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Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Disease | Nephroblastoma;FunDO |
Disease | Lung cancer;FunDO |
Disease | HDL cholesterol;NHGRI |
Disease | HDL cholesterol;GAD |
Disease | Breast cancer;FunDO |
Disease | METABOLIC;GAD |
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External Links |
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Links to Entrez Gene | 10664 |
Links to all GeneRIF Items | 10664 |
Links to iHOP | 10664 |
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Sequence Information |
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Nucleotide Sequence |
>10664 : length: 1200 atggcctttgtgaccagtggagaattggttcggcatcgtcgttacaaacacacccacgag aagccattcaagtgttccatgtgcgattacgccagtgtagaagtcagcaaattaaaacgt cacattcgctctcatactggagagcgtccgtttcagtgcagtttgtgcagttatgccagc agggacacatacaagctgaaaaggcacatgagaacccattcaggggaaaagccttatgaa tgttatatttgtcatgctcggtttacccaaagtggtaccatgaagatgcacattttacag aagcacacagaaaatgtggccaaatttcactgtccccactgtgacacagtcatagcccga aaaagtgatttgggtgtccacttgcgaaagcagcattcctatattgagcaaggcaagaaa tgccgttactgtgatgctgtgtttcatgagcgctatgccctcatccagcatcagaagtca cacaagaatgagaagcgctttaagtgtgaccagtgtgattacgcttgtagacaggagagg cacatgatcatgcacaagcgcacccacaccggggagaagccttacgcctgcagccactgc gataagaccttccgccagaagcagcttctcgacatgcacttcaagcgctatcacgacccc aacttcgtccctgcggcttttgtctgttctaagtgtgggaaaacatttacacgtcggaat accatggcaagacatgctgataattgtgctggcccagatggcgtagagggggaaaatgga ggagaaacgaagaagagtaaacgtggaagaaaaagaaagatgcgctctaagaaagaagat tcctctgacagtgaaaatgctgaaccagatctggacgacaatgaggatgaggaggagcct gccgtagaaattgaacctgagccagagcctcagcctgtgaccccagccccaccacccgcc aagaagcggagaggacgaccccctggcagaaccaaccagcccaaacagaaccagccaaca gctatcattcaggttgaagaccagaatacaggtgcaattgagaacattatagttgaagta aaaaaagagccagatgctgagcccgcagagggagaggaagaggaggcccagccagctgcc acagatgcccccaacggagacctcacgcccgagatgatcctcagcatgatggaccggtga |
Protein Sequence |
>10664 : length: 399 MAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYAS RDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIAR KSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER HMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRN TMARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEDEEEP AVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTNQPKQNQPTAIIQVEDQNTGAIENIIVEV KKEPDAEPAEGEEEEAQPAATDAPNGDLTPEMILSMMDR |