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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 11178 |
Name | LZTS1 |
Synonym | F37|FEZ1;leucine zipper, putative tumor suppressor 1;LZTS1;leucine zipper, putative tumor suppressor 1 |
Definition | F37/Esophageal cancer-related gene-coding leucine-zipper motif|leucine zipper putative tumor suppressor 1 |
Position | 8p22 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | "Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma." |
reviewed | Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. |
potential | Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. |
| More detail of all 3 literatures about LZTS1 | |
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Pathways and Diseases |
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Pathway | Transcription;Reactome;REACT:1788 |
Disease | Intraocular melanoma;FunDO |
Disease | Squamous cell cancer;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Esophageal squamous cell carcinoma;OMIM |
Disease | prostate cancer;GAD |
Disease | CANCER;GAD |
Disease | PSYCH;GAD |
Disease | major depressive disorder (broad);GAD |
Disease | Neoplasm metastasis;FunDO |
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External Links |
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Links to Entrez Gene | 11178 |
Links to all GeneRIF Items | 11178 |
Links to iHOP | 11178 |
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Sequence Information |
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Nucleotide Sequence |
>11178 : length: 1791 atgggcagcgtcagtagcctcatctccggccacagcttccacagcaagcactgccgggct tcgcagtacaagctgcgcaagtcctcccacctcaagaagctcaaccggtattccgacggg ctgctgaggtttggcttctcccaggactccggtcacggcaagtccagctccaaaatgggc aagagcgaagacttcttctacatcaaggtcagccagaaagcccggggctcccatcaccca gattacacggcactgtccagcggggatttagggggccaggctggggtggactttgacccg tccacaccccccaagctcatgcccttctccaatcagctagaaatgggctccgagaagggt gcagtgaggcccacagccttcaagcctgtgctgccacggtcaggagccatcctgcactcc tccccggagagtgccagccaccagctgcaccccgcccctccagacaagcccaaggagcag gagctgaagcctggcctgtgctctggggcgctgtcagactccggccggaactccatgtcc agcctgcccacacacagcaccagcagcagctaccagctggacccgctggtcacacccgtg ggacccacaagccgttttgggggctccgcccacaacatcacccagggcatcgtcctccag gacagcaacatgatgagcctgaaggctctgtccttctccgacggaggtagcaagctgggc cactcgaacaaggcagacaagggcccctcgtgtgtccgctcccccatctccacggacgag tgcagcatccaggagctggagcagaagctgttggagagggagggcgccctccagaagctg cagcgcagctttgaggagaaggagcttgcctccagcctggcctacgaggagcggccgcgg cgctgcagggacgagctggagggcccggagcccaaaggcggcaacaagctcaagcaggcc tcgcagaagagccagcgcgcgcagcaggtcctgcacctgcaggtactgcagcttcagcag gagaagcggcagctccggcaggagctcgagagcctcatgaaggagcaggacctgctggag accaagctcaggtcctacgagagggagaagaccagcttcggccccgcgctggaggagacc cagtgggaggtgtgccagaagtcaggcgagatctccctcctgaagcagcagctgaaggag tcccagacggaggtgaacgccaaggctagcgagatcctgggtctcaaggcacagctgaag gacacgcggggcaagctggagggcctggagctgaggacccaggacctggagggcgccctg cgcaccaagggcctggagctggaggtctgtgagaatgagctgcagcgcaagaagaacgag gcggagctgctgcgggagaaggtgaacctgctggagcaggagctgcaggagctgcgggcc caggccgccctggcccgcgacatggggccgcccaccttccccgaggacgtccctgccctg cagcgggagctggagcggctgcgggccgagctgcgggaggagcggcaaggccatgaccag atgtcctcgggcttccagcatgagcggctcgtgtggaaggaggagaaggagaaggtgatt cagtaccagaaacagctgcagcagagctacgtggccatgtaccagcggaaccagcgcctg gagaaggccctgcagcagctggcacgtggggacagcgccggggagcccttggaggttgac ctggaaggggctgacatcccctacgaggacatcatagccactgagatctga |
Protein Sequence |
>11178 : length: 596 MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI |