Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

11178

Name

LZTS1

Synonym

F37|FEZ1;leucine zipper, putative tumor suppressor 1;LZTS1;leucine zipper, putative tumor suppressor 1

Definition

F37/Esophageal cancer-related gene-coding leucine-zipper motif|leucine zipper putative tumor suppressor 1

Position

8p22

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,Generif,UniProt

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

potential

"Down-regulation of leucine zipper putative tumor suppressor 1 is associated with poor prognosis, increased cell motility and invasion, and epithelial-to-mesenchymal transition characteristics in human breast carcinoma."

reviewed

Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis.

potential

Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.
More detail of all 3 literatures about LZTS1

Pathways and Diseases

Pathway

Transcription;Reactome;REACT:1788

Disease

Intraocular melanoma;FunDO

Disease

Squamous cell cancer;FunDO

Disease

Prostate cancer;FunDO

Disease

Esophageal squamous cell carcinoma;OMIM

Disease

prostate cancer;GAD

Disease

CANCER;GAD

Disease

PSYCH;GAD

Disease

major depressive disorder (broad);GAD

Disease

Neoplasm metastasis;FunDO

External Links

Links to Entrez Gene

11178

Links to all GeneRIF Items

11178

Links to iHOP

11178

Sequence Information

Nucleotide Sequence

>11178 : length: 1791
atgggcagcgtcagtagcctcatctccggccacagcttccacagcaagcactgccgggct
tcgcagtacaagctgcgcaagtcctcccacctcaagaagctcaaccggtattccgacggg
ctgctgaggtttggcttctcccaggactccggtcacggcaagtccagctccaaaatgggc
aagagcgaagacttcttctacatcaaggtcagccagaaagcccggggctcccatcaccca
gattacacggcactgtccagcggggatttagggggccaggctggggtggactttgacccg
tccacaccccccaagctcatgcccttctccaatcagctagaaatgggctccgagaagggt
gcagtgaggcccacagccttcaagcctgtgctgccacggtcaggagccatcctgcactcc
tccccggagagtgccagccaccagctgcaccccgcccctccagacaagcccaaggagcag
gagctgaagcctggcctgtgctctggggcgctgtcagactccggccggaactccatgtcc
agcctgcccacacacagcaccagcagcagctaccagctggacccgctggtcacacccgtg
ggacccacaagccgttttgggggctccgcccacaacatcacccagggcatcgtcctccag
gacagcaacatgatgagcctgaaggctctgtccttctccgacggaggtagcaagctgggc
cactcgaacaaggcagacaagggcccctcgtgtgtccgctcccccatctccacggacgag
tgcagcatccaggagctggagcagaagctgttggagagggagggcgccctccagaagctg
cagcgcagctttgaggagaaggagcttgcctccagcctggcctacgaggagcggccgcgg
cgctgcagggacgagctggagggcccggagcccaaaggcggcaacaagctcaagcaggcc
tcgcagaagagccagcgcgcgcagcaggtcctgcacctgcaggtactgcagcttcagcag
gagaagcggcagctccggcaggagctcgagagcctcatgaaggagcaggacctgctggag
accaagctcaggtcctacgagagggagaagaccagcttcggccccgcgctggaggagacc
cagtgggaggtgtgccagaagtcaggcgagatctccctcctgaagcagcagctgaaggag
tcccagacggaggtgaacgccaaggctagcgagatcctgggtctcaaggcacagctgaag
gacacgcggggcaagctggagggcctggagctgaggacccaggacctggagggcgccctg
cgcaccaagggcctggagctggaggtctgtgagaatgagctgcagcgcaagaagaacgag
gcggagctgctgcgggagaaggtgaacctgctggagcaggagctgcaggagctgcgggcc
caggccgccctggcccgcgacatggggccgcccaccttccccgaggacgtccctgccctg
cagcgggagctggagcggctgcgggccgagctgcgggaggagcggcaaggccatgaccag
atgtcctcgggcttccagcatgagcggctcgtgtggaaggaggagaaggagaaggtgatt
cagtaccagaaacagctgcagcagagctacgtggccatgtaccagcggaaccagcgcctg
gagaaggccctgcagcagctggcacgtggggacagcgccggggagcccttggaggttgac
ctggaaggggctgacatcccctacgaggacatcatagccactgagatctga

Protein Sequence

>11178 : length: 596
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG
KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG
AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS
SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG
HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR
RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE
TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA
QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI
QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston Rights Reserved
Site Policies | State of Texas