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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 112399 |
Name | EGLN3 |
Synonym | HIFPH3|PHD3;egl nine homolog 3 (C. elegans);EGLN3;egl nine homolog 3 (C. elegans) |
Definition | HIF prolyl hydroxylase 3|HIF-PH3|HIF-prolyl hydroxylase 3|HPH-1|HPH-3|egl nine homolog 3|egl nine-like protein 3 isoform|hypoxia-inducible factor prolyl hydroxylase 3|prolyl hydroxylase domain-containing protein 3 |
Position | 14q13.1 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling, independent of its hydroxylase activity." |
| More detail of all 1 literatures about EGLN3 | |
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Pathways and Diseases |
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Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
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External Links |
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Links to Entrez Gene | 112399 |
Links to all GeneRIF Items | 112399 |
Links to iHOP | 112399 |
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Sequence Information |
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Nucleotide Sequence |
>112399 : length: 720 atgcccctgggacacatcatgaggctggacctggagaaaattgccctggagtacatcgtg ccctgtctgcacgaggtgggcttctgctacctggacaacttcctgggcgaggtggtgggc gactgcgtcctggagcgcgtcaagcagctgcactgcaccggggccctgcgggacggccag ctggcggggccgcgcgccggcgtctccaagcgacacctgcggggcgaccagatcacgtgg atcgggggcaacgaggagggctgcgaggccatcagcttcctcctgtccctcatcgacagg ctggtcctctactgcgggagccggctgggcaaatactacgtcaaggagaggtctaaggca atggtggcttgctatccgggaaatggaacaggttatgttcgccacgtggacaaccccaac ggtgatggtcgctgcatcacctgcatctactatctgaacaagaattgggatgccaagcta catggtgggatcctgcggatatttccagaggggaaatcattcatagcagatgtggagccc atttttgacagactcctgttcttctggtcagatcgtaggaacccacacgaagtgcagccc tcttacgcaaccagatatgctatgactgtctggtactttgatgctgaagaaagggcagaa gccaaaaagaaattcaggaatttaactaggaaaactgaatctgccctcactgaagactga |
Protein Sequence |
>112399 : length: 239 MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED |