Entrez Gene

Basic Information
Gene ID	11334
Name	TUSC2
Synonym	C3orf11\|FUS1\|PAP\|PDAP2;tumor suppressor candidate 2;TUSC2;tumor suppressor candidate 2
Definition	PDGFA associated protein 2\|PDGFA-associated protein 2\|fus-1 protein\|fusion 1 protein
Position	3p21.3
Gene Type	protein-coding
Source	Count: 3; Pubmed_search,Generif,UniProt
Literature support	Count: 8 PubMed records as below.
Evidence Status	Description
potential	The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 tumor suppressor Gene Consortium.
reviewed	Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells.
reviewed	Absence of tumor suppressor FUS1 protein expression is associated with bone and soft tissue sarcomas.
reviewed	"miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1."
reviewed	"These results suggest that miR-378 enhances cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1."
reviewed	Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.
reviewed	Myristoylation is required for Fus1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer.
potential	Overexpression of candidate tumor suppressor geneFUS1 isolated from the 3p21.3 homozygous deletionregion leads to G1 arrest and growth inhibition oflung cancer cells.
	More detail of all 8 literatures about TUSC2
External Links
Links to Entrez Gene	11334
Links to all GeneRIF Items	11334
Links to iHOP	11334
Sequence Information
Nucleotide Sequence	>11334 : length: 333 atgggcgccagcgggtccaaagctcggggcctgtggcccttcgcctcggcggccggaggc ggcggctcagaggcagcaggagctgagcaagctttggtgcggcctcggggccgagctgtg ccccccttcgtattcacgcgccgcggctctatgttctatgatgaggatggggatctggct cacgagttctatgaggagacaatcgtcaccaagaacgggcagaagcgggccaagctgagg cgagtgcataagaatctgattcctcagggcatcgtgaagctggatcacccccgcatccac gtggatttccctgtgatcctctatgaggtgtga
Protein Sequence	>11334 : length: 110 MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLA HEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV

Basic Information

Gene ID

11334

Name

TUSC2

Synonym

C3orf11|FUS1|PAP|PDAP2;tumor suppressor candidate 2;TUSC2;tumor suppressor candidate 2

Definition

PDGFA associated protein 2|PDGFA-associated protein 2|fus-1 protein|fusion 1 protein

Position

3p21.3

Gene Type

protein-coding

Source

Count: 3; Pubmed_search,Generif,UniProt

Literature support

Count: 8 PubMed records as below.

Evidence Status

Description

potential

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 tumor suppressor Gene Consortium.

reviewed

Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells.

reviewed

Absence of tumor suppressor FUS1 protein expression is associated with bone and soft tissue sarcomas.

reviewed

"miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1."

reviewed

"These results suggest that miR-378 enhances cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1."

reviewed

Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.

reviewed

Myristoylation is required for Fus1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer.

potential

Overexpression of candidate tumor suppressor geneFUS1 isolated from the 3p21.3 homozygous deletionregion leads to G1 arrest and growth inhibition oflung cancer cells.

More detail of all 8 literatures about TUSC2

External Links

Links to Entrez Gene

11334

Links to all GeneRIF Items

11334

Links to iHOP

11334

Sequence Information

Nucleotide Sequence

>11334 : length: 333
atgggcgccagcgggtccaaagctcggggcctgtggcccttcgcctcggcggccggaggc
ggcggctcagaggcagcaggagctgagcaagctttggtgcggcctcggggccgagctgtg
ccccccttcgtattcacgcgccgcggctctatgttctatgatgaggatggggatctggct
cacgagttctatgaggagacaatcgtcaccaagaacgggcagaagcgggccaagctgagg
cgagtgcataagaatctgattcctcagggcatcgtgaagctggatcacccccgcatccac
gtggatttccctgtgatcctctatgaggtgtga

Protein Sequence

>11334 : length: 110
MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLA
HEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV