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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1147 |
Name | CHUK |
Synonym | IKBKA|IKK-alpha|IKK1|IKKA|NFKBIKA|TCF16;conserved helix-loop-helix ubiquitous kinase;CHUK;conserved helix-loop-helix ubiquitous kinase |
Definition | I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16 |
Position | 10q24-q25 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "in the mammalian skin, IKK1 functions as a differentiation regulator and tumor suppressor through the Notch signaling path". |
potential | IKKalpha may function as a tumor suppressor gene. |
| More detail of all 2 literatures about CHUK | |
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Pathways and Diseases |
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Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | RIG-I-like receptor signaling pathway;KEGG PATHWAY;hsa04622 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | AKT phosphorylates targets in the cytosol;PID Reactome;500640 |
Pathway | Viral dsRNA:TLR3:TRIF Complex Activates RIP1;PID Reactome;500448 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | human TAK1 activates NFkB by phosphorylation and activation of IKKs complex;PID Reactome;500450 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | akt signaling pathway;PID BioCarta;100245 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | TRAIL signaling pathway;PID Curated;200056 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Pathway | nf-kb signaling pathway;PID BioCarta;100097 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | signal transduction through il1r;PID BioCarta;100132 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | Alternative NF-kappaB pathway;PID Curated;200037 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ras signaling pathway;PID BioCarta;100047 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | IL1-mediated signaling events;PID Curated;200075 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha;PID Curated;200133 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | tnf/stress related signaling;PID BioCarta;100026 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Endogenous TLR signaling;PID Curated;200177 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Virus disease;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Infectious lung disease;FunDO |
Disease | Obesity;FunDO |
Disease | Leukemia;FunDO |
Disease | Polyarthritis;FunDO |
Disease | plasma levels of liver enzymes;GAD |
Disease | Neoplasm metastasis;FunDO |
Disease | METABOLIC;GAD |
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External Links |
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Links to Entrez Gene | 1147 |
Links to all GeneRIF Items | 1147 |
Links to iHOP | 1147 |
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Sequence Information |
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Nucleotide Sequence |
>1147 : length: 2238 atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg ctgggcaccggcggcttcgggaacgtctgtctgtaccagcatcgggaacttgatctcaaa atagcaattaagtcttgtcgcctagagctaagtaccaaaaacagagaacgatggtgccat gaaatccagattatgaagaagttgaaccatgccaatgttgtaaaggcctgtgatgttcct gaagaattgaatattttgattcatgatgtgcctcttctagcaatggaatactgttctgga ggagatctccgaaagctgctcaacaaaccagaaaattgttgtggacttaaagaaagccag atactttctttactaagtgatatagggtctgggattcgatatttgcatgaaaacaaaatt atacatcgagatctaaaacctgaaaacatagttcttcaggatgttggtggaaagataata cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctgtgtacatct tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttacacagcc actgttgattattggagctttgggaccatggtatttgaatgtattgctggatataggcct tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag tgtatatttgcatgtgaagagatgtcaggagaagttcggtttagtagccatttacctcaa ccaaatagcctttgtagtttagtagtagaacccatggaaaactggctacagttgatgttg aattgggaccctcagcagagaggaggacctgttgaccttactttgaagcagccaagatgt tttgtattaatggatcacattttgaatttgaagatagtacacatcctaaatatgacttct gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt attgagcgtgaaactggaataaatactggttctcaagaacttctttcagagacaggaatt tctctggatcctcggaaaccagcctctcaatgtgttctagatggagttagaggctgtgat agctatatggtttatttgtttgataaaagtaaaactgtatatgaagggccatttgcttcc agaagtttatctgattgtgtaaattatattgtacaggacagcaaaatacagcttccaatt atacagctgcgtaaagtgtgggctgaagcagtgcactatgtgtctggactaaaagaagac tatagcaggctctttcagggacaaagggcagcaatgttaagtcttcttagatataatgct aacttaacaaaaatgaagaacactttgatctcagcatcacaacaactgaaagctaaattg gagttttttcacaaaagcattcagcttgacttggagagatacagcgagcagatgacgtat gggatatcttcagaaaaaatgctaaaagcatggaaagaaatggaagaaaaggccatccac tatgctgaggttggtgtcattggatacctggaggatcagattatgtctttgcatgctgaa atcatggagctacagaagagcccctatggaagacgtcagggagacttgatggaatctctg gaacagcgtgccattgatctatataagcagttaaaacacagaccttcagatcactcctac agtgacagcacagagatggtgaaaatcattgtgcacactgtgcagagtcaggaccgtgtg ctcaaggagctgtttggtcatttgagcaagttgttgggctgtaagcagaagattattgat ctactccctaaggtggaagtggccctcagtaatatcaaagaagctgacaatactgtcatg ttcatgcagggaaaaaggcagaaagaaatatggcatctccttaaaattgcctgtacacag agttctgcccggtcccttgtaggatccagtctagaaggtgcagtaacccctcagacatca gcatggctgcccccgacttcagcagaacatgatcattctctgtcatgtgtggtaactcct caagatggggagacttcagcacaaatgatagaagaaaatttgaactgccttggccattta agcactattattcatgaggcaaatgaggaacagggcaatagtatgatgaatcttgattgg agttggttaacagaatga |
Protein Sequence |
>1147 : length: 745 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL STIIHEANEEQGNSMMNLDWSWLTE |