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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1191 |
Name | CLU |
Synonym | APO-J|APOJ|CLI|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2;clusterin;CLU;clusterin |
Definition | aging-associated protein 4|apolipoprotein J|complement cytolysis inhibitor|complement lysis inhibitor|complement-associated protein SP-40,40|ku70-binding protein 1|sulfated glycoprotein 2|testosterone-repressed prostate message 2 |
Position | 8p21-p12 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | "Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas." |
potential | "CLU acts as a tumor suppressor in the early stages of carcinogenesis, but CLU may also represent a pro-survival stimulus confering increased resistance to anti-cancer drugs or enhancing tumour cell survival in specific niches. Review." |
potential | "Results suggest that proteasome inhibition may induce prostate cancer cell death through accumulation of n-clusterin, a potential tumor suppressor factor." |
| More detail of all 3 literatures about CLU | |
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Pathways and Diseases |
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Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | Hemostasis;Reactome;REACT:604 |
Disease | Lupus erythematosus;FunDO |
Disease | Alzheimer's disease;GAD |
Disease | Bladder cancer;FunDO |
Disease | Panic disorder;NHGRI |
Disease | carotid atherosclerosis;GAD |
Disease | Melanoma;FunDO |
Disease | Breast cancer;FunDO |
Disease | Esophagus cancer;FunDO |
Disease | Hypercholesterolemia;FunDO |
Disease | Von Hippel-Lindau syndrome;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Serous cancer;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | panic disorder;GAD |
Disease | METABOLIC;GAD |
Disease | Kidney disease;FunDO |
Disease | Colon cancer;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Larynx cancer;FunDO |
Disease | Nephrosis;FunDO |
Disease | Pre-Eclampsia;FunDO |
Disease | PSYCH;GAD |
Disease | Alzheimer's disease;NHGRI |
Disease | preeclampsia;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Endometrial cancer;FunDO |
Disease | hypertension;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Renal Cell cancer;FunDO |
Disease | Hypertension;FunDO |
Disease | cholesterol, LDL;GAD |
Disease | cholesterol;GAD |
Disease | Azoospermia;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | Vascular disease;FunDO |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 1191 |
Links to all GeneRIF Items | 1191 |
Links to iHOP | 1191 |
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Sequence Information |
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Nucleotide Sequence |
>1191 : length: 1383 atggaggcgtgcaaagactccagaattggaggcatgatgaagactctgctgctgtttgtg gggctgctgctgacctgggagagtgggcaggtcctgggggaccagacggtctcagacaat gagctccaggaaatgtccaatcagggaagtaagtacgtcaataaggaaattcaaaatgct gtcaacggggtgaaacagataaagactctcatagaaaaaacaaacgaagagcgcaagaca ctgctcagcaacctagaagaagccaagaagaagaaagaggatgccctaaatgagaccagg gaatcagagacaaagctgaaggagctcccaggagtgtgcaatgagaccatgatggccctc tgggaagagtgtaagccctgcctgaaacagacctgcatgaagttctacgcacgcgtctgc agaagtggctcaggcctggttggccgccagcttgaggagttcctgaaccagagctcgccc ttctacttctggatgaatggtgaccgcatcgactccctgctggagaacgaccggcagcag acgcacatgctggatgtcatgcaggaccacttcagccgcgcgtccagcatcatagacgag ctcttccaggacaggttcttcacccgggagccccaggatacctaccactacctgcccttc agcctgccccaccggaggcctcacttcttctttcccaagtcccgcatcgtccgcagcttg atgcccttctctccgtacgagcccctgaacttccacgccatgttccagcccttccttgag atgatacacgaggctcagcaggccatggacatccacttccatagcccggccttccagcac ccgccaacagaattcatacgagaaggcgacgatgaccggactgtgtgccgggagatccgc cacaactccacgggctgcctgcggatgaaggaccagtgtgacaagtgccgggagatcttg tctgtggactgttccaccaacaacccctcccaggctaagctgcggcgggagctcgacgaa tccctccaggtcgctgagaggttgaccaggaaatacaacgagctgctaaagtcctaccag tggaagatgctcaacacctcctccttgctggagcagctgaacgagcagtttaactgggtg tcccggctggcaaacctcacgcaaggcgaagaccagtactatctgcgggtcaccacggtg gcttcccacacttctgactcggacgttccttccggtgtcactgaggtggtcgtgaagctc tttgactctgatcccatcactgtgacggtccctgtagaagtctccaggaagaaccctaaa tttatggagaccgtggcggagaaagcgctgcaggaataccgcaaaaagcaccgggaggag tga |
Protein Sequence |
>1191 : length: 460 MEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNA VNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMAL WEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQ THMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSL MPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIR HNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQ WKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKL FDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE |