|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 144165 |
Name | PRICKLE1 |
Synonym | EPM1B|RILP;prickle homolog 1 (Drosophila);PRICKLE1;prickle homolog 1 (Drosophila) |
Definition | REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein|REST/NRSF-interacting LIM domain protein 1|prickle-like 1|prickle-like protein 1 |
Position | 12q12 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
|
Evidence Status |
Description |
potential | Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma. |
| More detail of all 1 literatures about PRICKLE1 | |
|
Pathways and Diseases |
|
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Disease | Heart failure;NHGRI |
Disease | Epilepsy, progressive myoclonic 1B;OMIM |
|
External Links |
|
Links to Entrez Gene | 144165 |
Links to all GeneRIF Items | 144165 |
Links to iHOP | 144165 |
|
Sequence Information |
|
Nucleotide Sequence |
>144165 : length: 2496 atgcctttggagatggagcccaagatgagcaaactggcctttggctgtcagagaagttcc acatcagatgatgactctggctgtgcattggaggagtacgcctgggtccccccgggcctg agaccagagcagatccagctctattttgcttgcttaccagaggaaaaagttccttacgtt aacagccccggagagaagcatcggattaaacagcttttgtaccagttaccaccacatgat aatgaggtacggtattgccagtctttgagtgaagaggagaaaaaagagttgcaggtgttc agtgctcagcggaagaaagaagcactgggaagaggaacaattaagcttctgtccagagca gtcatgcatgctgtgtgtgagcagtgtggtttgaagataaatggaggtgaagttgcagtg ttcgcctcccgtgcgggccctggtgtgtgctggcacccatcctgttttgtctgtttcacg tgtaatgagctgctggtcgacctcatctatttttatcaggatggaaaaattcactgtggc aggcaccatgcagaactgctcaaaccacggtgctcagcatgtgacgagataatttttgct gatgagtgcacagaagctgagggtcgccattggcacatgaaacacttctgctgccttgag tgtgaaacggtcctgggaggacagaggtatatcatgaaggacggccgccccttctgctgt ggctgttttgagtctctctatgcggagtactgtgaaacctgtggggaacatattggtgtg gaccatgcacagatgacctatgacgggcagcactggcacgccacggaagcctgcttttct tgtgcccagtgtaaagcctctttgttgggatgtcccttccttcccaaacagggtcagatt tactgctcaaaaacgtgcagtcttggtgaagacgtccatgcctctgattcttccgactct gcatttcagtcagctcgatcaagagactcccgaagaagtgtccgaatgggcaagagcagc cggtcagcagatcagtgtagacagtctctcctcttatcgcctgctctgaactacaagttt cctggcctctcaggcaatgctgatgacaccctttctcgaaaattggatgatctgagtctc tccagacaaggaacaagttttgccagtgaagaattttggaaaggcagagtagagcaggaa actccagaagaccctgaagaatgggctgatcatgaagattatatgacgcagctcctcctc aagtttggtgataaaagcctctttcagccacagcccaatgagatggatattcgagccagt gagcactggatatctgataacatggttaaaagtaagaccgagttaaagcaaaataaccag agccttgcaagtaaaaaataccagtctgatatgtactgggcacagtcacaagatggactg ggcgattctgcttatggcagccacccaggccctgcaagcagtagaaggcttcaggaattg gaactggaccatggggcttcagggtataatcatgatgaaacacagtggtatgaagattcc ctggagtgtctgtcagacctgaaaccagagcaaagtgttcgggattcgatggattctttg gcattgtccaatatcacaggggcttcggtggatggagaaaacaagccaaggccatcattg tattctctgcaaaattttgaggagatggaaacagaagattgtgagaagatgagcaatatg ggaactttgaactcttccatgctgcacaggagtgcagagtccttaaagagtctaagttca gagttgtgtccagagaaaatcctgcctgaagagaagccagtacatctgccagtgctcaga aggtccaagtctcaatccagaccccagcaggtcaagttttctgatgatgtcattgacaat gggaactatgacattgaaatccggcagcctccgatgagtgaaaggactcggagacgcgtc tacaattttgaagagaggggatccaggtctcatcaccaccgccgccggagaagtagaaag tcccgctccgacaatgccctgaatcttgttacagaaagaaaatactctcccaaggacaga ctgcggctgtacacccccgataactatgagaaatttatacagaataaaagtgcccgggag atccaagcatacatccagaatgctgatctctacggacagtacgcccatgccacttccgat tatggcctgcagaacccaggaatgaatcggtttctgggactctacggcgaggatgatgat tcctggtgttcttcctcctcctcctcttccgactcggaagaagaaggatattttcttgga caaccaatccctcaaccccggccacagagatttgcctactatacagatgacctttctagt ccaccatctgcacttcccacccctcagtttggtcagaggacaacaaaatccaagaagaaa aagggacacaagggcaaaaattgtattatttcttaa |
Protein Sequence |
>144165 : length: 831 MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYV NSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRA VMHAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC GCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQI YCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKF PGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQETPEDPEEWADHEDYMTQLLL KFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGL GDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSL ALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSS ELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTRRRV YNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSARE IQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLG QPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS |