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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 160728 |
Name | SLC5A8 |
Synonym | AIT|SMCT|SMCT1;solute carrier family 5 (iodide transporter), member 8;SLC5A8;solute carrier family 5 (iodide transporter), member 8 |
Definition | apical iodide transporter|electrogenic sodium monocarboxylate cotransporter|sodium iodide-related cotransporter|sodium-coupled monocarboxylate transporter 1|solute carrier family 5 member 8 |
Position | 12q23.1 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 7 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "In acute myeloid leukemia with mixed lineage leukemia partial tandem duplication, the SLC5A8 tumor suppressor gene promoter was more frequently hypermethylated." |
reviewed | Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. |
potential | SLC5A8 may function as a tumor suppressor gene whose silencing may contribute to carcinogenesis and progression of pancreatic cancer. |
potential | Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. |
reviewed | Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. |
reviewed | "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids." |
reviewed | "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers." |
| More detail of all 7 literatures about SLC5A8 | |
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Pathways and Diseases |
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Pathway | Amino acid and oligopeptide SLC transporters;Reactome;REACT:19419 |
Pathway | Transmembrane transport of small molecules;Reactome;REACT:15518 |
Pathway | Organic anion transporters;PID Reactome;500342 |
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External Links |
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Links to Entrez Gene | 160728 |
Links to all GeneRIF Items | 160728 |
Links to iHOP | 160728 |
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Sequence Information |
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Nucleotide Sequence |
>160728 : length: 1833 atggacacgccacggggcatcggcaccttcgtggtgtgggactacgtggtgttcgcgggc atgctggtcatctcggccgccatcggcatctactacgccttcgctgggggcggccagcag acctccaaggacttcctgatgggcggccgcagaatgaccgcagtgcccgtggcgctgtcc ctcaccgctagcttcatgtcagccgtcactgtcctgggcaccccctccgaggtctaccgt tttggggccatttttagcatctttgccttcacctacttctttgtggtggtcatcagcgcg gaggtcttcctcccggtgttctacaaactgggaattaccagcacctacgagtatttagaa cttcgatttaacaaatgtgttcgtctctgtggaacagtcctcttcattgttcaaacaatt ctgtatactggaattgttatttatgcccctgccctggctttgaatcaagtcacaggattt gatctgtggggcgcggtagtggcaacgggggtggtctgcacattctactgcacactgggt ggtcttaaagcagttatctggacagatgtttttcaagttgggatcatggtggctggattt gcatccgtgattatacaggctgtggtgatgcaaggtggaatcagcactattttaaatgat gcctatgatggtggaagattaaatttctggaattttaatcctaaccctttgcaaagacac accttctggacaattattataggagggaccttcacatggaccagcatctacggtgtcaac caatcccaggtgcagagatatatttcttgtaaaagcagattccaggcaaaactgtctctc tacatcaatcttgtgggactctgggcaatcctcacatgctcagtgttttgtgggctcgcc ctatattccaggtaccatgactgtgatccttggacagccaagaaagtgtctgcaccagac cagctcatgccttatttggtactggacattctgcaagattatccaggacttcctggactt tttgtggcctgtgcttacagtgggacattaagcacagtgtcctccagtattaatgcctta gcagcagtaactgtggaagatctaatcaaaccttacttcagatcgctctcagaaaggtct ctgtcttggatttcccaaggaatgagtgtggtgtatggagccctgtgtattggaatggct gcgctggcgtcacttatgggagctttgttgcaggcagcactcagcgtatttggtatggtt ggtggaccacttatgggcctgttcgctttgggcattttggttccctttgccaactcaatt ggagcacttgttggtctgatggctggatttgccatttctctatgggttggaattggagct caaatatatcctccacttcctgagagaacattgccattgcaccttgatatccaaggctgt aacagcacctacaatgagacaaatttgatgacaaccacagaaatgccatttactactagt gtttttcaaatatacaatgttcaaaggactccactgatggataactggtattctttatca tatctgtacttcagcactgttggaactttggtaacattattagtggggatacttgtcagt ttatcaacaggaggaagaaaacagaacttagaccccagatacatactaaccaaagaggac tttttatccaattttgatatttttaagaaaaagaagcatgttttgagctataaatcacat ccagtggaagatggtggaactgataatcctgctttcaaccacattgaattgaactcagat cagagtggcaagagcaatgggactcgtttgtga |
Protein Sequence |
>160728 : length: 610 MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALS LTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLE LRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLG GLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRH TFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLA LYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINAL AAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMV GGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGC NSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVS LSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSD QSGKSNGTRL |