Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

1612

Name

DAPK1

Synonym

DAPK;death-associated protein kinase 1;DAPK1;death-associated protein kinase 1

Definition

DAP kinase 1

Position

9q34.1

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 6 PubMed records as below.

Evidence Status

Description

reviewed

tumor suppressor death-associated protein kinase is required for full IL-1β production.

reviewed

The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation.

reviewed

"Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China."

potential

"TIMP3, DAPK1 and AKR1B10 are important for squamous cell lung cancer tumorogenesis while AKR1B10 is potential oncogene whereas TIMP3 and DAPK1 are potential tumor suppressor genes."

reviewed

Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer.

reviewed

The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.
More detail of all 6 literatures about DAPK1

Pathways and Diseases

Pathway

Apoptosis;Reactome;REACT:578

Pathway

Role of DCC in regulating apoptosis;PID Reactome;500280

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

IFN-gamma pathway;PID Curated;200110

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Netrin-mediated signaling;PID Curated;200074

Disease

Cancers;KEGG DISEASE

Disease

smoking cessation;GAD

Disease

CHEMDEPENDENCY;GAD

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Gastritis;FunDO

Disease

Cancer;FunDO

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Epilepsy;FunDO

Disease

Alzheimer's disease;GAD

Disease

NEUROLOGICAL;GAD

Disease

Bronchial disease;FunDO

External Links

Links to Entrez Gene

1612

Links to all GeneRIF Items

1612

Links to iHOP

1612

Sequence Information

Nucleotide Sequence

>1612 : length: 4293
atgaccgtgttcaggcaggaaaacgtggatgattactacgacaccggcgaggaacttggc
agtggacagtttgcggttgtgaagaaatgccgtgagaaaagcaccggcctccagtatgcc
gccaaattcatcaagaaaaggaggactaagtccagccggcggggtgtgagccgcgaggac
atcgagcgggaggtcagcatcctgaaggagatccagcaccccaatgtcatcaccctgcac
gaggtctatgagaacaagacggacgtcatcctgatcttggaactcgttgcaggtggcgag
ctgtttgacttcttagctgaaaaggaatctttaactgaagaggaagcaactgaatttctc
aaacaaattcttaatggtgtttactacctgcactcccttcaaatcgcccactttgatctt
aagcctgagaacataatgcttttggatagaaatgtccccaaacctcggatcaagatcatt
gactttgggttggcccataaaattgactttggaaatgaatttaaaaacatatttgggact
ccagagtttgtcgctcctgagatagtcaactatgaacctcttggtcttgaggcagatatg
tggagtatcggggtaataacctatatcctcctaagtggggcctccccatttcttggagac
actaagcaagaaacgttagcaaatgtatccgctgtcaactacgaatttgaggatgaatac
ttcagtaataccagtgccctagccaaagatttcataagaagacttctggtcaaggatcca
aagaagagaatgacaattcaagatagtttgcagcatccctggatcaagcctaaagataca
caacaggcacttagtagaaaagcatcagcagtaaacatggagaaattcaagaagtttgca
gcccggaaaaaatggaaacaatccgttcgcttgatatcactgtgccaaagattatccagg
tcattcctgtccagaagtaacatgagtgttgccagaagcgatgatactctggatgaggaa
gactcctttgtgatgaaagccatcatccatgccatcaacgatgacaatgtcccaggcctg
cagcaccttctgggctcattatccaactatgatgttaaccaacccaacaagcacgggaca
cctccattactcattgctgctggctgtgggaatattcaaatactacagttgctcattaaa
agaggctcgagaatcgatgtccaggataagggcgggtccaatgccgtctactgggctgct
cggcatggccacgtcgataccttgaaatttctcagtgagaacaaatgccctttggatgtg
aaagacaagtctggagagatggccctccacgtggcagctcgctatggccatgctgacgtg
gctcagttactgtgcagcttcggctcaaatcccaatatccaggacaaggaagaagaaacc
cccctgcactgtgctgcttggcacggctattactctgtggccaaagccctttgtgaagcc
ggctgtaacgtgaacatcaagaaccgagaaggagagacgcccctcctgacagcctctgcc
aggggctaccacgacatcgtggagtgtctggccgaacatggagccgaccttaatgcttgc
gacaaggacggacacattgcccttcatctggctgtaagacggtgtcagatggaggtaatc
aagactctcctcagccaagggtgtttcgtcgattatcaagacaggcacggcaatactccc
ctccatgtggcatgtaaagatggcaacatgcctatcgtggtggccctctgtgaagcaaac
tgcaatttggacatctccaacaagtatgggcgaacgcctctgcaccttgcggccaacaac
ggaatcctagacgtggtccggtatctctgtctgatgggagccagcgttgaggcgctgacc
acggacggaaagacggcagaagatcttgctagatcggaacagcacgagcacgtagcaggt
ctccttgcaagacttcgaaaggatacgcaccgaggactcttcatccagcagctccgaccc
acacagaacctgcagccaagaattaagctcaagctgtttggccactcgggatccgggaaa
accacccttgtagaatctctcaagtgtgggctgctgaggagctttttcagaaggcgtcgg
cccagactgtcttccaccaactccagcaggttcccaccttcacccctggcttctaagccc
acagtctcagtgagcatcaacaacctgtacccaggctgcgagaacgtgagtgtgaggagc
cgcagcatgatgttcgagccgggtcttaccaaagggatgctggaggtgtttgtggccccg
acccaccacccgcactgctcggccgatgaccagtccaccaaggccatcgacatccagaac
gcttatttgaatggagttggcgatttcagcgtgtgggagttctctggaaatcctgtgtat
ttctgctgttatgactattttgctgcaaatgatcccacgtcaatccatgttgttgtcttt
agtctagaagagccctatgagatccagctgaaccaagtgattttctggctcagtttcctg
aagtcccttgtcccagttgaagaacccatagccttcggtggcaagctgaagaacccactc
caagttgtcctggtggccacccacgctgacatcatgaatgttcctcgaccggctggaggc
gagtttggatatgacaaagacacatcgttgctgaaagagattaggaacaggtttggaaat
gatcttcacatttcaaataagctgtttgttctggatgctggggcttctgggtcaaaggac
atgaaggtacttcgaaatcatctgcaagaaatacgaagccagattgtttcggtctgtcct
cccatgactcacctgtgtgagaaaatcatctccacgctgccttcctggaggaagctcaat
ggacccaaccagctgatgtcgctgcagcagtttgtgtacgacgtgcaggaccagctgaac
cccctggccagcgaggaggacctcaggcgcattgctcagcagctccacagcacaggcgag
atcaacatcatgcaaagtgaaacagttcaggacgtgctgctcctggacccccgctggctc
tgcacaaacgtcctggggaagttgctgtccgtggagaccccacgggcgctgcaccactac
cggggccgctacaccgtggaggacatccagcgcctggtgcccgacagcgacgtggaggag
ctgctgcagatcctcgatgccatggacatctgcgcccgggacctgagcagcgggaccatg
gtggacgtcccagccctgatcaagacagacaacctgcaccgctcctgggctgatgaggag
gacgaggtgatggtgtatggtggcgtgcgcatcgtgcccgtggaacacctcacccccttc
ccatgtggcatctttcacaaggtccaggtgaacctgtgccggtggatccaccagcaaagc
acagagggcgacgcggacatccgcctgtgggtgaatggctgcaagctggccaaccgtggg
gccgagctgctggtgctgctggtcaaccacggccagggcattgaggtccaggtccgcggc
ctggagacggagaagatcaagtgctgcctgctgctggactcggtgtgcagcaccattgag
aacgtcatggccaccacgctgccagggctcctgaccgtgaagcattacctgagcccccag
cagctgcgggagcaccatgagcccgtcatgatctaccagccacgggacttcttccgggca
cagactctgaaggaaacctcactgaccaacaccatgggggggtacaaggaaagcttcagc
agcatcatgtgcttcgggtgtcacgacgtctactcacaggccagcctcggcatggacatc
catgcatcagacctgaacctcctcactcggaggaaactgagtcgcctgctggacccgccc
gaccccctggggaaggactggtgccttctcgccatgaacttaggcctccctgacctcgtg
gcaaagtacaacaccagtaacggggctcccaaggatttcctccccagccccctccacgcc
ctgctgcgggaatggaccacctaccctgagagcacagtgggcaccctcatgtccaaactg
agggagctgggtcgccgggatgccgcagactttttgctgaaggcatcctctgtgttcaaa
atcaacctggatggcaatggccaggaggcctatgcctcgagctgcaacagcggcacctct
tacaattccattagctctgttgtatcccggtga

Protein Sequence

>1612 : length: 1430
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED
IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL
KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY
FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA
ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA
RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET
PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN
CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG
LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP
THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF
SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG
EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP
PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE
INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE
LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF
PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG
LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA
QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP
DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL
RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR



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