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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1612 |
Name | DAPK1 |
Synonym | DAPK;death-associated protein kinase 1;DAPK1;death-associated protein kinase 1 |
Definition | DAP kinase 1 |
Position | 9q34.1 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 6 PubMed records as below. |
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Evidence Status |
Description |
reviewed | tumor suppressor death-associated protein kinase is required for full IL-1β production. |
reviewed | The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation. |
reviewed | "Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China." |
potential | "TIMP3, DAPK1 and AKR1B10 are important for squamous cell lung cancer tumorogenesis while AKR1B10 is potential oncogene whereas TIMP3 and DAPK1 are potential tumor suppressor genes." |
reviewed | Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. |
reviewed | The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. |
| More detail of all 6 literatures about DAPK1 | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Role of DCC in regulating apoptosis;PID Reactome;500280 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Cancers;KEGG DISEASE |
Disease | smoking cessation;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | Gastritis;FunDO |
Disease | Cancer;FunDO |
Disease | Bladder cancer;KEGG DISEASE;H00022 |
Disease | Epilepsy;FunDO |
Disease | Alzheimer's disease;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | Bronchial disease;FunDO |
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External Links |
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Links to Entrez Gene | 1612 |
Links to all GeneRIF Items | 1612 |
Links to iHOP | 1612 |
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Sequence Information |
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Nucleotide Sequence |
>1612 : length: 4293 atgaccgtgttcaggcaggaaaacgtggatgattactacgacaccggcgaggaacttggc agtggacagtttgcggttgtgaagaaatgccgtgagaaaagcaccggcctccagtatgcc gccaaattcatcaagaaaaggaggactaagtccagccggcggggtgtgagccgcgaggac atcgagcgggaggtcagcatcctgaaggagatccagcaccccaatgtcatcaccctgcac gaggtctatgagaacaagacggacgtcatcctgatcttggaactcgttgcaggtggcgag ctgtttgacttcttagctgaaaaggaatctttaactgaagaggaagcaactgaatttctc aaacaaattcttaatggtgtttactacctgcactcccttcaaatcgcccactttgatctt aagcctgagaacataatgcttttggatagaaatgtccccaaacctcggatcaagatcatt gactttgggttggcccataaaattgactttggaaatgaatttaaaaacatatttgggact ccagagtttgtcgctcctgagatagtcaactatgaacctcttggtcttgaggcagatatg tggagtatcggggtaataacctatatcctcctaagtggggcctccccatttcttggagac actaagcaagaaacgttagcaaatgtatccgctgtcaactacgaatttgaggatgaatac ttcagtaataccagtgccctagccaaagatttcataagaagacttctggtcaaggatcca aagaagagaatgacaattcaagatagtttgcagcatccctggatcaagcctaaagataca caacaggcacttagtagaaaagcatcagcagtaaacatggagaaattcaagaagtttgca gcccggaaaaaatggaaacaatccgttcgcttgatatcactgtgccaaagattatccagg tcattcctgtccagaagtaacatgagtgttgccagaagcgatgatactctggatgaggaa gactcctttgtgatgaaagccatcatccatgccatcaacgatgacaatgtcccaggcctg cagcaccttctgggctcattatccaactatgatgttaaccaacccaacaagcacgggaca cctccattactcattgctgctggctgtgggaatattcaaatactacagttgctcattaaa agaggctcgagaatcgatgtccaggataagggcgggtccaatgccgtctactgggctgct cggcatggccacgtcgataccttgaaatttctcagtgagaacaaatgccctttggatgtg aaagacaagtctggagagatggccctccacgtggcagctcgctatggccatgctgacgtg gctcagttactgtgcagcttcggctcaaatcccaatatccaggacaaggaagaagaaacc cccctgcactgtgctgcttggcacggctattactctgtggccaaagccctttgtgaagcc ggctgtaacgtgaacatcaagaaccgagaaggagagacgcccctcctgacagcctctgcc aggggctaccacgacatcgtggagtgtctggccgaacatggagccgaccttaatgcttgc gacaaggacggacacattgcccttcatctggctgtaagacggtgtcagatggaggtaatc aagactctcctcagccaagggtgtttcgtcgattatcaagacaggcacggcaatactccc ctccatgtggcatgtaaagatggcaacatgcctatcgtggtggccctctgtgaagcaaac tgcaatttggacatctccaacaagtatgggcgaacgcctctgcaccttgcggccaacaac ggaatcctagacgtggtccggtatctctgtctgatgggagccagcgttgaggcgctgacc acggacggaaagacggcagaagatcttgctagatcggaacagcacgagcacgtagcaggt ctccttgcaagacttcgaaaggatacgcaccgaggactcttcatccagcagctccgaccc acacagaacctgcagccaagaattaagctcaagctgtttggccactcgggatccgggaaa accacccttgtagaatctctcaagtgtgggctgctgaggagctttttcagaaggcgtcgg cccagactgtcttccaccaactccagcaggttcccaccttcacccctggcttctaagccc acagtctcagtgagcatcaacaacctgtacccaggctgcgagaacgtgagtgtgaggagc cgcagcatgatgttcgagccgggtcttaccaaagggatgctggaggtgtttgtggccccg acccaccacccgcactgctcggccgatgaccagtccaccaaggccatcgacatccagaac gcttatttgaatggagttggcgatttcagcgtgtgggagttctctggaaatcctgtgtat ttctgctgttatgactattttgctgcaaatgatcccacgtcaatccatgttgttgtcttt agtctagaagagccctatgagatccagctgaaccaagtgattttctggctcagtttcctg aagtcccttgtcccagttgaagaacccatagccttcggtggcaagctgaagaacccactc caagttgtcctggtggccacccacgctgacatcatgaatgttcctcgaccggctggaggc gagtttggatatgacaaagacacatcgttgctgaaagagattaggaacaggtttggaaat gatcttcacatttcaaataagctgtttgttctggatgctggggcttctgggtcaaaggac atgaaggtacttcgaaatcatctgcaagaaatacgaagccagattgtttcggtctgtcct cccatgactcacctgtgtgagaaaatcatctccacgctgccttcctggaggaagctcaat ggacccaaccagctgatgtcgctgcagcagtttgtgtacgacgtgcaggaccagctgaac cccctggccagcgaggaggacctcaggcgcattgctcagcagctccacagcacaggcgag atcaacatcatgcaaagtgaaacagttcaggacgtgctgctcctggacccccgctggctc tgcacaaacgtcctggggaagttgctgtccgtggagaccccacgggcgctgcaccactac cggggccgctacaccgtggaggacatccagcgcctggtgcccgacagcgacgtggaggag ctgctgcagatcctcgatgccatggacatctgcgcccgggacctgagcagcgggaccatg gtggacgtcccagccctgatcaagacagacaacctgcaccgctcctgggctgatgaggag gacgaggtgatggtgtatggtggcgtgcgcatcgtgcccgtggaacacctcacccccttc ccatgtggcatctttcacaaggtccaggtgaacctgtgccggtggatccaccagcaaagc acagagggcgacgcggacatccgcctgtgggtgaatggctgcaagctggccaaccgtggg gccgagctgctggtgctgctggtcaaccacggccagggcattgaggtccaggtccgcggc ctggagacggagaagatcaagtgctgcctgctgctggactcggtgtgcagcaccattgag aacgtcatggccaccacgctgccagggctcctgaccgtgaagcattacctgagcccccag cagctgcgggagcaccatgagcccgtcatgatctaccagccacgggacttcttccgggca cagactctgaaggaaacctcactgaccaacaccatgggggggtacaaggaaagcttcagc agcatcatgtgcttcgggtgtcacgacgtctactcacaggccagcctcggcatggacatc catgcatcagacctgaacctcctcactcggaggaaactgagtcgcctgctggacccgccc gaccccctggggaaggactggtgccttctcgccatgaacttaggcctccctgacctcgtg gcaaagtacaacaccagtaacggggctcccaaggatttcctccccagccccctccacgcc ctgctgcgggaatggaccacctaccctgagagcacagtgggcaccctcatgtccaaactg agggagctgggtcgccgggatgccgcagactttttgctgaaggcatcctctgtgttcaaa atcaacctggatggcaatggccaggaggcctatgcctcgagctgcaacagcggcacctct tacaattccattagctctgttgtatcccggtga |
Protein Sequence |
>1612 : length: 1430 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR |