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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1739 |
Name | DLG1 |
Synonym | DLGH1|SAP-97|SAP97|dJ1061C18.1.1|hdlg;discs, large homolog 1 (Drosophila);DLG1;discs, large homolog 1 (Drosophila) |
Definition | disks large homolog 1|presynaptic protein SAP97|synapse-associated protein 97 |
Position | 3q29 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,TAG,Generif |
Literature support | Count: 14 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. |
reviewed | "Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein." |
reviewed | DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene. |
reviewed | Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. |
reviewed | Functional involvement of human discs large tumor suppressor in cytokinesis. |
reviewed | The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. |
potential | Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein. |
reviewed | "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein." |
reviewed | Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor. |
reviewed | Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. |
| More detail of all 14 literatures about DLG1 | |
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Pathways and Diseases |
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Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Trafficking of AMPA receptors;PID Reactome;500171 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
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External Links |
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Links to Entrez Gene | 1739 |
Links to all GeneRIF Items | 1739 |
Links to iHOP | 1739 |
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Sequence Information |
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Nucleotide Sequence |
>1739 : length: 2715 atgccggtccggaagcaagatacccagagagcattgcaccttttggaggaatatcgttca aaactaagccaaactgaagacagacagctcagaagttccatagaacgggttattaacata tttcagagcaacctctttcaggctttaatagatattcaagaattttatgaagtgacctta ctggataatccaaaatgtatagatcgttcaaagccgtctgaaccaattcaacctgtgaat acttgggagatttccagccttccaagctctactgtgacttcagagacactgccaagcagc cttagccctagtgtagagaaatacaggtatcaggatgaagatacacctcctcaagagcat atttccccacaaatcacaaatgaagtgataggtccagaattggttcatgtctcagagaag aacttatcagagattgagaatgtccatggatttgtttctcattctcatatttcaccaata aagccaacagaagctgttcttccctctcctcccactgtccctgtgatccctgtcctgcca gtccctgctgagaatactgtcatcctacccaccataccacaggcaaatcctcccccagta ctggtcaacacagatagcttggaaacaccaacttacgttaatggcacagatgcagattat gaatatgaagaaatcacacttgaaaggggaaattcagggcttggtttcagcattgcagga ggtacggacaacccacacattggagatgactcaagtattttcattaccaaaattatcaca gggggagcagccgcccaagatggaagattgcgggtcaatgactgtatattacgagtaaat gaagtagatgttcgtgatgtaacacatagcaaagcagttgaagcgttgaaagaagcaggg tctattgtacgcttgtatgtaaaaagaaggaaaccagtgtcagaaaaaataatggaaata aagctcattaaaggtcctaaaggtcttgggtttagcattgctggaggtgttggaaatcag catattcctggggataatagcatctatgtaaccaaaataattgaaggaggtgcagcacat aaggatggcaaacttcagattggagataaacttttagcagtgaataacgtatgtttagaa gaagttactcatgaagaagcagtaactgccttaaagaacacatctgattttgtttatttg aaagtggcaaaacccacaagtatgtatatgaatgatggctatgcaccacctgatatcacc aactcttcttctcagcctgttgataaccatgttagcccatcttccttcttgggccagaca ccagcatctccagccagatactccccagtttctaaagcagtacttggagatgatgaaatt acaagggaacctagaaaagttgttcttcatcgtggctcaacgggccttggtttcaacatt gtaggaggagaagatggagaaggaatatttatttcctttatcttagccggaggacctgct gatctaagtggagagctcagaaaaggagatcgtattatatcggtaaacagtgttgacctc agagctgctagtcatgagcaggcagcagctgcattgaaaaatgctggccaggctgtcaca attgttgcacaatatcgacctgaagaatacagtcgttttgaagctaaaatacatgattta cgggagcagatgatgaatagtagtattagttcagggtcaggttctcttcgaactagccag aagcgatccctctatgtcagagccctttttgattatgacaagactaaagacagtgggctt cccagtcagggactgaacttcaaatttggagatatcctccatgttattaatgcttctgat gatgaatggtggcaagccaggcaggttacaccagatggtgagagcgatgaggtcggagtg attcccagtaaacgcagagttgagaagaaagaacgagcccgattaaaaacagtgaaattc aattctaaaacgagagataaaggggagatccctgacgacatgggatcaaaaggcctgaag catgtaacttctaatgccagcgatagtgaaagtagttaccgtggtcaagaagaatacgtc ttatcttatgaaccagtgaatcaacaagaagttaattatactcgaccagtgatcatattg ggacctatgaaagacaggataaatgatgacttgatctcagaatttcctgacaaatttgga tcctgtgttcctcatacaactagaccaaaacgagattatgaggtagatggaagagattat cattttgtgacttcaagagagcagatggaaaaagatatccaggaacataaattcattgaa gctggccagtataacaatcatctatatggaacaagtgttcagtctgtacgagaagtagca gaaaagggcaaacactgtatccttgatgtgtctggaaatgccataaagagattacagatt gcacagctttaccctatctccatttttattaaacccaaatccatggaaaatatcatggaa atgaataagcgtctaacagaagaacaagccagaaaaacatttgagagagccatgaaactg gaacaggagtttactgaacatttcacagctattgtacagggggatacgctggaagacatt tacaaccaagtgaaacagatcatagaagaacaatctggttcttacatctgggttccggca aaagaaaagctatga |
Protein Sequence |
>1739 : length: 904 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA KEKL |