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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2048 |
Name | EPHB2 |
Synonym | CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5;EPH receptor B2;EPHB2;EPH receptor B2 |
Definition | EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protei |
Position | 1p36.1-p35 |
Gene Type | protein-coding |
Source | Count: 3; Pubmed_search,Generif,UniProt |
Literature support | Count: 4 PubMed records as below. |
|
Evidence Status |
Description |
reviewed | "The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer." |
reviewed | "at least in the context of pancreatic carcinoma CFPAC-1 cells, EphB2 plays a tumor suppressor role in cell proliferation and apoptosis". |
reviewed | The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways. |
reviewed | A tumor suppressor role for EPHB2 in rare colorectal cancer cases; rare germline EPHB2 variants may contribute to a small fraction of hereditary colorectal cancer. |
| More detail of all 4 literatures about EPHB2 | |
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Pathways and Diseases |
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Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | EphrinB-EPHB pathway;PID Curated;200141 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | L1CAM interactions;PID Reactome;500097 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Disease | CANCER;GAD |
Disease | Prostate cancer, progression and metastasis of;OMIM |
Disease | prostate cancer;GAD |
Disease | Congenital abnormality;FunDO |
Disease | Cancer;FunDO |
Disease | colorectal cancer hyperplastic polyposis;GAD |
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External Links |
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Links to Entrez Gene | 2048 |
Links to all GeneRIF Items | 2048 |
Links to iHOP | 2048 |
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Sequence Information |
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Nucleotide Sequence |
>2048 : length: 2964 atggctctgcggaggctgggggccgcgctgctgctgctgccgctgctcgccgccgtggaa gaaacgctaatggactccactacagcgactgctgagctgggctggatggtgcatcctcca tcagggtgggaagaggtgagtggctacgatgagaacatgaacacgatccgcacgtaccag gtgtgcaacgtgtttgagtcaagccagaacaactggctacggaccaagtttatccggcgc cgtggcgcccaccgcatccacgtggagatgaagttttcggtgcgtgactgcagcagcatc cccagcgtgcctggctcctgcaaggagaccttcaacctctattactatgaggctgacttt gactcggccaccaagaccttccccaactggatggagaatccatgggtgaaggtggatacc attgcagccgacgagagcttctcccaggtggacctgggtggccgcgtcatgaaaatcaac accgaggtgcggagcttcggacctgtgtcccgcagcggcttctacctggccttccaggac tatggcggctgcatgtccctcatcgccgtgcgtgtcttctaccgcaagtgcccccgcatc atccagaatggcgccatcttccaggaaaccctgtcgggggctgagagcacatcgctggtg gctgcccggggcagctgcatcgccaatgcggaagaggtggatgtacccatcaagctctac tgtaacggggacggcgagtggctggtgcccatcgggcgctgcatgtgcaaagcaggcttc gaggccgttgagaatggcaccgtctgccgaggttgtccatctgggactttcaaggccaac caaggggatgaggcctgtacccactgtcccatcaacagccggaccacttctgaaggggcc accaactgtgtctgccgcaatggctactacagagcagacctggaccccctggacatgccc tgcacaaccatcccctccgcgccccaggctgtgatttccagtgtcaatgagacctccctc atgctggagtggacccctccccgcgactccggaggccgagaggacctcgtctacaacatc atctgcaagagctgtggctcgggccggggtgcctgcacccgctgcggggacaatgtacag tacgcaccacgccagctaggcctgaccgagccacgcatttacatcagtgacctgctggcc cacacccagtacaccttcgagatccaggctgtgaacggcgttactgaccagagccccttc tcgcctcagttcgcctctgtgaacatcaccaccaaccaggcagctccatcggcagtgtcc atcatgcatcaggtgagccgcaccgtggacagcattaccctgtcgtggtcccagccggac cagcccaatggcgtgatcctggactatgagctgcagtactatgagaaggagctcagtgag tacaacgccacagccataaaaagccccaccaacacggtcaccgtgcagggcctcaaagcc ggcgccatctatgtcttccaggtgcgggcacgcaccgtggcaggctacgggcgctacagc ggcaagatgtacttccagaccatgacagaagccgagtaccagacaagcatccaggagaag ttgccactcatcatcggctcctcggccgctggcctggtcttcctcattgctgtggttgtc atcgccatcgtgtgtaacagaagacgggggtttgagcgtgctgactcggagtacacggac aagctgcaacactacaccagtggccacatgaccccaggcatgaagatctacatcgatcct ttcacctacgaggaccccaacgaggcagtgcgggagtttgccaaggaaattgacatctcc tgtgtcaaaattgagcaggtgatcggagcaggggagtttggcgaggtctgcagtggccac ctgaagctgccaggcaagagagagatctttgtggccatcaagacgctcaagtcgggctac acggagaagcagcgccgggacttcctgagcgaagcctccatcatgggccagttcgaccat cccaacgtcatccacctggagggtgtcgtgaccaagagcacacctgtgatgatcatcacc gagttcatggagaatggctccctggactcctttctccggcaaaacgatgggcagttcaca gtcatccagctggtgggcatgcttcggggcatcgcagctggcatgaagtacctggcagac atgaactatgttcaccgtgacctggctgcccgcaacatcctcgtcaacagcaacctggtc tgcaaggtgtcggactttgggctctcacgctttctagaggacgatacctcagaccccacc tacaccagtgccctgggcggaaagatccccatccgctggacagccccggaagccatccag taccggaagttcacctcggccagtgatgtgtggagctacggcattgtcatgtgggaggtg atgtcctatggggagcggccctactgggacatgaccaaccaggatgtaatcaatgccatt gagcaggactatcggctgccaccgcccatggactgcccgagcgccctgcaccaactcatg ctggactgttggcagaaggaccgcaaccaccggcccaagttcggccaaattgtcaacacg ctagacaagatgatccgcaatcccaacagcctcaaagccatggcgcccctctcctctggc atcaacctgccgctgctggaccgcacgatccccgactacaccagctttaacacggtggac gagtggctggaggccatcaagatggggcagtacaaggagagcttcgccaatgccggcttc acctcctttgacgtcgtgtctcagatgatgatggaggacattctccgggttggggtcact ttggctggccaccagaaaaaaatcctgaacagtatccaggtgatgcgggcgcagatgaac cagattcagtctgtggaggtttga |
Protein Sequence |
>2048 : length: 987 MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK LPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDP FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY TEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSG INLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVT LAGHQKKILNSIQVMRAQMNQIQSVEV |