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General information | Expression | Regulation | Mutation | Interaction |
Basic Information |
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Gene ID | 2050 |
Name | EPHB4 |
Synonym | HTK|MYK1|TYRO11;EPH receptor B4;EPHB4;EPH receptor B4 |
Definition | ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK |
Position | 7q22 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 3 PubMed records as below. |
Evidence Status |
Description |
potential | EPHB4 can function as a tumor suppressor in acute lymphoblastic leukemia. |
potential | "Study provides evidence showing that promoter methylation regulates EPHB4 transcription and that EPHB4 can regulate the long-term clonogenic potential of colorectal tumor cells, revealing EPHB4 as a potential tumor suppressor gene in colorectal cancer." |
reviewed | The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. |
More detail of all 3 literatures about EPHB4 | |
Pathways and Diseases |
|
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | EphrinB-EPHB pathway;PID Curated;200141 |
Disease | Cancer;FunDO |
External Links |
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Links to Entrez Gene | 2050 |
Links to all GeneRIF Items | 2050 |
Links to iHOP | 2050 |
Sequence Information |
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Nucleotide Sequence |
>2050 : length: 2964 atggagctccgggtgctgctctgctgggcttcgttggccgcagctttggaagagaccctg ctgaacacaaaattggaaactgctgatctgaagtgggtgacattccctcaggtggacggg cagtgggaggaactgagcggcctggatgaggaacagcacagcgtgcgcacctacgaagtg tgtgacgtgcagcgtgccccgggccaggcccactggcttcgcacaggttgggtcccacgg cggggcgccgtccacgtgtacgccacgctgcgcttcaccatgctcgagtgcctgtccctg cctcgggctgggcgctcctgcaaggagaccttcaccgtcttctactatgagagcgatgcg gacacggccacggccctcacgccagcctggatggagaacccctacatcaaggtggacacg gtggccgcggagcatctcacccggaagcgccctggggccgaggccaccgggaaggtgaat gtcaagacgctgcgtctgggaccgctcagcaaggctggcttctacctggccttccaggac cagggtgcctgcatggccctgctatccctgcacctcttctacaaaaagtgcgcccagctg actgtgaacctgactcgattcccggagactgtgcctcgggagctggttgtgcccgtggcc ggtagctgcgtggtggatgccgtccccgcccctggccccagccccagcctctactgccgt gaggatggccagtgggccgaacagccggtcacgggctgcagctgtgctccggggttcgag gcagctgaggggaacaccaagtgccgagcctgtgcccagggcaccttcaagcccctgtca ggagaagggtcctgccagccatgcccagccaatagccactctaacaccattggatcagcc gtctgccagtgccgcgtcgggtacttccgggcacgcacagacccccggggtgcaccctgc accacccctccttcggctccgcggagcgtggtttcccgcctgaacggctcctccctgcac ctggaatggagtgcccccctggagtctggtggccgagaggacctcacctacgccctccgc tgccgggagtgccgacccggaggctcctgtgcgccctgcgggggagacctgacttttgac cccggcccccgggacctggtggagccctgggtggtggttcgagggctacgtcctgacttc acctatacctttgaggtcactgcattgaacggggtatcctccttagccacggggcccgtc ccatttgagcctgtcaatgtcaccactgaccgagaggtacctcctgcagtgtctgacatc cgggtgacgcggtcctcacccagcagcttgagcctggcctgggctgttccccgggcaccc agtggggctgtgctggactacgaggtcaaataccatgagaagggcgccgagggtcccagc agcgtgcggttcctgaagacgtcagaaaaccgggcagagctgcgggggctgaagcgggga gccagctacctggtgcaggtacgggcgcgctctgaggccggctacgggcccttcggccag gaacatcacagccagacccaactggatgagagcgagggctggcgggagcagctggccctg attgcgggcacggcagtcgtgggtgtggtcctggtcctggtggtcattgtggtcgcagtt ctctgcctcaggaagcagagcaatgggagagaagcagaatattcggacaaacacggacag tatctcatcggacatggtactaaggtctacatcgaccccttcacttatgaagaccctaat gaggctgtgagggaatttgcaaaagagatcgatgtctcctacgtcaagattgaagaggtg attggtgcaggtgagtttggcgaggtgtgccgggggcggctcaaggccccagggaagaag gagagctgtgtggcaatcaagaccctgaagggtggctacacggagcggcagcggcgtgag tttctgagcgaggcctccatcatgggccagttcgagcaccccaatatcatccgcctggag ggcgtggtcaccaacagcatgcccgtcatgattctcacagagttcatggagaacggcgcc ctggactccttcctgcggctaaacgacggacagttcacagtcatccagctcgtgggcatg ctgcggggcatcgcctcgggcatgcggtaccttgccgagatgagctacgtccaccgagac ctggctgctcgcaacatcctagtcaacagcaacctcgtctgcaaagtgtctgactttggc ctttcccgattcctggaggagaactcttccgatcccacctacacgagctccctgggagga aagattcccatccgatggactgccccggaggccattgccttccggaagttcacttccgcc agtgatgcctggagttacgggattgtgatgtgggaggtgatgtcatttggggagaggccg tactgggacatgagcaatcaggacgtgatcaatgccattgaacaggactaccggctgccc ccgcccccagactgtcccacctccctccaccagctcatgctggactgttggcagaaagac cggaatgcccggccccgcttcccccaggtggtcagcgccctggacaagatgatccggaac cccgccagcctcaaaatcgtggcccgggagaatggcggggcctcacaccctctcctggac cagcggcagcctcactactcagcttttggctctgtgggcgagtggcttcgggccatcaaa atgggaagatacgaagaaagtttcgcagccgctggctttggctccttcgagctggtcagc cagatctctgctgaggacctgctccgaatcggagtcactctggcgggacaccagaagaaa atcttggccagtgtccagcacatgaagtcccaggccaagccgggaaccccgggtgggaca ggaggaccggccccgcagtactga |
Protein Sequence |
>2050 : length: 987 MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEV CDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDA DTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQD QGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCR EDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSA VCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALR CRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPV PFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPS SVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAL IAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPN EAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGM LRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGG KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP PPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLD QRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKK ILASVQHMKSQAKPGTPGGTGGPAPQY |
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