Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2050

Name

EPHB4

Synonym

HTK|MYK1|TYRO11;EPH receptor B4;EPHB4;EPH receptor B4

Definition

ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK

Position

7q22

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 3 PubMed records as below.

Evidence Status

Description

potential

EPHB4 can function as a tumor suppressor in acute lymphoblastic leukemia.

potential

"Study provides evidence showing that promoter methylation regulates EPHB4 transcription and that EPHB4 can regulate the long-term clonogenic potential of colorectal tumor cells, revealing EPHB4 as a potential tumor suppressor gene in colorectal cancer."

reviewed

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.
More detail of all 3 literatures about EPHB4

Pathways and Diseases

Pathway

Axon guidance;KEGG PATHWAY;hsa04360

Pathway

Ephrin B reverse signaling;PID Curated;200173

Pathway

EPHB forward signaling;PID Curated;200041

Pathway

EphrinB-EPHB pathway;PID Curated;200141

Disease

Cancer;FunDO

External Links

Links to Entrez Gene

2050

Links to all GeneRIF Items

2050

Links to iHOP

2050

Sequence Information

Nucleotide Sequence

>2050 : length: 2964
atggagctccgggtgctgctctgctgggcttcgttggccgcagctttggaagagaccctg
ctgaacacaaaattggaaactgctgatctgaagtgggtgacattccctcaggtggacggg
cagtgggaggaactgagcggcctggatgaggaacagcacagcgtgcgcacctacgaagtg
tgtgacgtgcagcgtgccccgggccaggcccactggcttcgcacaggttgggtcccacgg
cggggcgccgtccacgtgtacgccacgctgcgcttcaccatgctcgagtgcctgtccctg
cctcgggctgggcgctcctgcaaggagaccttcaccgtcttctactatgagagcgatgcg
gacacggccacggccctcacgccagcctggatggagaacccctacatcaaggtggacacg
gtggccgcggagcatctcacccggaagcgccctggggccgaggccaccgggaaggtgaat
gtcaagacgctgcgtctgggaccgctcagcaaggctggcttctacctggccttccaggac
cagggtgcctgcatggccctgctatccctgcacctcttctacaaaaagtgcgcccagctg
actgtgaacctgactcgattcccggagactgtgcctcgggagctggttgtgcccgtggcc
ggtagctgcgtggtggatgccgtccccgcccctggccccagccccagcctctactgccgt
gaggatggccagtgggccgaacagccggtcacgggctgcagctgtgctccggggttcgag
gcagctgaggggaacaccaagtgccgagcctgtgcccagggcaccttcaagcccctgtca
ggagaagggtcctgccagccatgcccagccaatagccactctaacaccattggatcagcc
gtctgccagtgccgcgtcgggtacttccgggcacgcacagacccccggggtgcaccctgc
accacccctccttcggctccgcggagcgtggtttcccgcctgaacggctcctccctgcac
ctggaatggagtgcccccctggagtctggtggccgagaggacctcacctacgccctccgc
tgccgggagtgccgacccggaggctcctgtgcgccctgcgggggagacctgacttttgac
cccggcccccgggacctggtggagccctgggtggtggttcgagggctacgtcctgacttc
acctatacctttgaggtcactgcattgaacggggtatcctccttagccacggggcccgtc
ccatttgagcctgtcaatgtcaccactgaccgagaggtacctcctgcagtgtctgacatc
cgggtgacgcggtcctcacccagcagcttgagcctggcctgggctgttccccgggcaccc
agtggggctgtgctggactacgaggtcaaataccatgagaagggcgccgagggtcccagc
agcgtgcggttcctgaagacgtcagaaaaccgggcagagctgcgggggctgaagcgggga
gccagctacctggtgcaggtacgggcgcgctctgaggccggctacgggcccttcggccag
gaacatcacagccagacccaactggatgagagcgagggctggcgggagcagctggccctg
attgcgggcacggcagtcgtgggtgtggtcctggtcctggtggtcattgtggtcgcagtt
ctctgcctcaggaagcagagcaatgggagagaagcagaatattcggacaaacacggacag
tatctcatcggacatggtactaaggtctacatcgaccccttcacttatgaagaccctaat
gaggctgtgagggaatttgcaaaagagatcgatgtctcctacgtcaagattgaagaggtg
attggtgcaggtgagtttggcgaggtgtgccgggggcggctcaaggccccagggaagaag
gagagctgtgtggcaatcaagaccctgaagggtggctacacggagcggcagcggcgtgag
tttctgagcgaggcctccatcatgggccagttcgagcaccccaatatcatccgcctggag
ggcgtggtcaccaacagcatgcccgtcatgattctcacagagttcatggagaacggcgcc
ctggactccttcctgcggctaaacgacggacagttcacagtcatccagctcgtgggcatg
ctgcggggcatcgcctcgggcatgcggtaccttgccgagatgagctacgtccaccgagac
ctggctgctcgcaacatcctagtcaacagcaacctcgtctgcaaagtgtctgactttggc
ctttcccgattcctggaggagaactcttccgatcccacctacacgagctccctgggagga
aagattcccatccgatggactgccccggaggccattgccttccggaagttcacttccgcc
agtgatgcctggagttacgggattgtgatgtgggaggtgatgtcatttggggagaggccg
tactgggacatgagcaatcaggacgtgatcaatgccattgaacaggactaccggctgccc
ccgcccccagactgtcccacctccctccaccagctcatgctggactgttggcagaaagac
cggaatgcccggccccgcttcccccaggtggtcagcgccctggacaagatgatccggaac
cccgccagcctcaaaatcgtggcccgggagaatggcggggcctcacaccctctcctggac
cagcggcagcctcactactcagcttttggctctgtgggcgagtggcttcgggccatcaaa
atgggaagatacgaagaaagtttcgcagccgctggctttggctccttcgagctggtcagc
cagatctctgctgaggacctgctccgaatcggagtcactctggcgggacaccagaagaaa
atcttggccagtgtccagcacatgaagtcccaggccaagccgggaaccccgggtgggaca
ggaggaccggccccgcagtactga

Protein Sequence

>2050 : length: 987
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEV
CDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDA
DTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQD
QGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCR
EDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSA
VCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALR
CRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPV
PFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPS
SVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAL
IAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPN
EAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE
FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGM
LRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGG
KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP
PPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLD
QRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKK
ILASVQHMKSQAKPGTPGGTGGPAPQY



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