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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 2066 |
Name | ERBB4 |
Synonym | HER4|p180erbB4;v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);ERBB4;v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
Definition | avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4 |
Position | 2q33.3-q34 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "Pregnancy and extended lactation durations have been correlated with reduced risk of breast cancer, and the role of ErbB4 in tumor suppression may therefore be linked with its role in lactation." |
potential | "These data suggest that ErbB4 behaves as a mammary tumor suppressor and that loss of ErbB4 coupling to growth arrest may be an important event in mammary tumorigenesis." |
reviewed | "results suggest that ErbB4 is not a potent, highly penetrant tumor suppressor, nor is it a factor in Neu-mediated tumorigenesis in this model". |
| More detail of all 3 literatures about ERBB4 | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | ErbB receptor signaling network;PID Curated;200136 |
Pathway | g-secretase mediated erbb4 signaling pathway;PID BioCarta;100172 |
Disease | Schizophrenia;FunDO |
Disease | Cancer;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | PSYCH;GAD |
Disease | schizophrenia;GAD |
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External Links |
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Links to Entrez Gene | 2066 |
Links to all GeneRIF Items | 2066 |
Links to iHOP | 2066 |
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Sequence Information |
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Nucleotide Sequence |
>2066 : length: 3879 atgaagccggcgacaggactttgggtctgggtgagccttctcgtggcggcggggaccgtc cagcccagcgattctcagtcagtgtgtgcaggaacggagaataaactgagctctctctct gacctggaacagcagtaccgagccttgcgcaagtactatgaaaactgtgaggttgtcatg ggcaacctggagataaccagcattgagcacaaccgggacctctccttcctgcggtctgtt cgagaagtcacaggctacgtgttagtggctcttaatcagtttcgttacctgcctctggag aatttacgcattattcgtgggacaaaactttatgaggatcgatatgccttggcaatattt ttaaactacagaaaagatggaaactttggacttcaagaacttggattaaagaacttgaca gaaatcctaaatggtggagtctatgtagaccagaacaaattcctttgttatgcagacacc attcattggcaagatattgttcggaacccatggccttccaacttgactcttgtgtcaaca aatggtagttcaggatgtggacgttgccataagtcctgtactggccgttgctggggaccc acagaaaatcattgccagactttgacaaggacggtgtgtgcagaacaatgtgacggcaga tgctacggaccttacgtcagtgactgctgccatcgagaatgtgctggaggctgctcagga cctaaggacacagactgctttgcctgcatgaatttcaatgacagtggagcatgtgttact cagtgtccccaaacctttgtctacaatccaaccacctttcaactggagcacaatttcaat gcaaagtacacatatggagcattctgtgtcaagaaatgtccacataactttgtggtagat tccagttcttgtgtgcgtgcctgccctagttccaagatggaagtagaagaaaatgggatt aaaatgtgtaaaccttgcactgacatttgcccaaaagcttgtgatggcattggcacagga tcattgatgtcagctcagactgtggattccagtaacattgacaaattcataaactgtacc aagatcaatgggaatttgatctttctagtcactggtattcatggggacccttacaatgca attgaagccatagacccagagaaactgaacgtctttcggacagtcagagagataacaggt ttcctgaacatacagtcatggccaccaaacatgactgacttcagtgttttttctaacctg gtgaccattggtggaagagtactctatagtggcctgtccttgcttatcctcaagcaacag ggcatcacctctctacagttccagtccctgaaggaaatcagcgcaggaaacatctatatt actgacaacagcaacctgtgttattatcataccattaactggacaacactcttcagcaca atcaaccagagaatagtaatccgggacaacagaaaagctgaaaattgtactgctgaagga atggtgtgcaaccatctgtgttccagtgatggctgttggggacctgggccagaccaatgt ctgtcgtgtcgccgcttcagtagaggaaggatctgcatagagtcttgtaacctctatgat ggtgaatttcgggagtttgagaatggctccatctgtgtggagtgtgacccccagtgtgag aagatggaagatggcctcctcacatgccatggaccgggtcctgacaactgtacaaagtgc tctcattttaaagatggcccaaactgtgtggaaaaatgtccagatggcttacagggggca aacagtttcattttcaagtatgctgatccagatcgggagtgccacccatgccatccaaac tgcacccaagggtgtaacggtcccactagtcatgactgcatttactacccatggacgggc cattccactttaccacaacatgctagaactcccctgattgcagctggagtaattggtggg ctcttcattctggtcattgtgggtctgacatttgctgtttatgttagaaggaagagcatc aaaaagaaaagagccttgagaagattcttggaaacagagttggtggaaccattaactccc agtggcacagcacccaatcaagctcaacttcgtattttgaaagaaactgagctgaagagg gtaaaagtccttggctcaggtgcttttggaacggtttataaaggtatttgggtacctgaa ggagaaactgtgaagattcctgtggctattaagattcttaatgagacaactggtcccaag gcaaatgtggagttcatggatgaagctctgatcatggcaagtatggatcatccacaccta gtccggttgctgggtgtgtgtctgagcccaaccatccagctggttactcaacttatgccc catggctgcctgttggagtatgtccacgagcacaaggataacattggatcacaactgctg cttaactggtgtgtccagatagctaagggaatgatgtacctggaagaaagacgactcgtt catcgggatttggcagcccgtaatgtcttagtgaaatctccaaaccatgtgaaaatcaca gattttgggctagccagactcttggaaggagatgaaaaagagtacaatgctgatggagga aagatgccaattaaatggatggctctggagtgtatacattacaggaaattcacccatcag agtgacgtttggagctatggagttactatatgggaactgatgacctttggaggaaaaccc tatgatggaattccaacgcgagaaatccctgatttattagagaaaggagaacgtttgcct cagcctcccatctgcactattgacgtttacatggtcatggtcaaatgttggatgattgat gctgacagtagacctaaatttaaggaactggctgctgagttttcaaggatggctcgagac cctcaaagatacctagttattcagggtgatgatcgtatgaagcttcccagtccaaatgac agcaagttctttcagaatctcttggatgaagaggatttggaagatatgatggatgctgag gagtacttggtccctcaggctttcaacatcccacctcccatctatacttccagagcaaga attgactcgaataggaaccagtttgtataccgagatggaggttttgctgctgaacaagga gtgtctgtgccctacagagccccaactagcacaattccagaagctcctgtggcacagggt gctactgctgagatttttgatgactcctgctgtaatggcaccctacgcaagccagtggca ccccatgtccaagaggacagtagcacccagaggtacagtgctgaccccaccgtgtttgcc ccagaacggagcccacgaggagagctggatgaggaaggttacatgactcctatgcgagac aaacccaaacaagaatacctgaatccagtggaggagaacccttttgtttctcggagaaaa aatggagaccttcaagcattggataatcccgaatatcacaatgcatccaatggtccaccc aaggccgaggatgagtatgtgaatgagccactgtacctcaacacctttgccaacaccttg ggaaaagctgagtacctgaagaacaacatactgtcaatgccagagaaggccaagaaagcg tttgacaaccctgactactggaaccacagcctgccacctcggagcacccttcagcaccca gactacctgcaggagtacagcacaaaatatttttataaacagaatgggcggatccggcct attgtggcagagaatcctgaatacctctctgagttctccctgaagccaggcactgtgctg ccgcctccaccttacagacaccggaatactgtggtgtaa |
Protein Sequence |
>2066 : length: 1292 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV |