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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2137 |
Name | EXTL3 |
Synonym | BOTV|EXTR1|REG|REGR|RPR;exostoses (multiple)-like 3;EXTL3;exostoses (multiple)-like 3 |
Definition | EXT-related protein 1|exostosin-like 3|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|hereditary multiple exostoses gene isolog|multiple exostosis-like protein 3|putative tumor suppressor protein EXTL3|reg receptor |
Position | 8p21 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | Exostoses like-3 (EXTL3) is a putative tumour suppressor gene. |
reviewed | "Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis." |
| More detail of all 2 literatures about EXTL3 | |
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Pathways and Diseases |
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Pathway | Glycosaminoglycan biosynthesis - heparan sulfate;KEGG PATHWAY;hsa00534 |
Pathway | heparan sulfate biosynthesis;BioCyc;PWY-6564 |
Pathway | heparan sulfate biosynthesis (late stages);BioCyc;PWY-6558 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Disease | Colon cancer;FunDO |
Disease | Adenoma;FunDO |
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External Links |
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Links to Entrez Gene | 2137 |
Links to all GeneRIF Items | 2137 |
Links to iHOP | 2137 |
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Sequence Information |
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Nucleotide Sequence |
>2137 : length: 2760 atgacaggctataccatgctgcggaatgggggcgcggggaacggaggtcagacctgcatg ctgcgctggtccaaccgcatccgcctcacgtggctcagcttcacgctctttgtcatcctg gtcttcttcccgctcatcgcccactattacctcaccactctggatgaggctgatgaggca ggcaagcggatttttggtccccgggtggggaacgagctgtgcgaggtgaagcacgtgctg gatctgtgccgcatccgggagtcggtgagtgaagagctcctgcagctggaggccaagcgc caagagctgaacagcgagatcgccaagctgaatctgaagatcgaagcctgtaagaagagc attgagaacgccaagcaggacctgctccagctcaagaatgtcatcagccagaccgagcat tcctacaaggagctcatggcccagaaccagcccaagctgtccctgcccatccgactgctc ccagagaaggacgatgccggcctccctcccccgaaggccactcggggctgccggctacac aactgctttgattattctcgttgccctctcacctctggcttcccggtctacgtctatgac agtgaccagtttgtctttggcagctacctggatcccttggtcaagcaggcttttcaggcg acagcacgagctaacgtttatgttacagaaaatgcagacatcgcctgcctttacgtgata ctagtgggagagatgcaggagcccgtggtgctgcggcctgctgagctggagaagcagttg tattccctgccacactggcggacggatggacacaaccatgtcatcatcaatctgtcacgt aagtcagatacacagaaccttctctataacgtcagtactggccgtgccatggtggcccag tccaccttctacactgtccagtacagacctggctttgacttggtcgtatcaccgctggtc catgccatgtctgagcccaacttcatggaaatcccaccacaggtgccggtgaagcggaaa tatctcttcaccttccagggcgagaagattgagtctctgaggtctagccttcaggaggcc cgctccttcgaagaggaaatggagggcgaccctcccgccgactacgatgaccggatcatt gccaccctgaaggcggtgcaggacagcaagctggatcaggtcctggtggaattcacctgc aaaaaccagcccaaacccagcctgccgactgagtgggcactgtgtggagagcgggaggac cgcttggaattgctgaagctctccaccttcgccctcatcattacccccggggaccctcgc ttggttatttcctctgggtgtgcaacacggctcttcgaagccctggaagtcggtgccgtc ccggtggtgctgggggagcaggtccagcttccctaccaggacatgctgcagtggaacgag gcggccctggtggtgccaaagcctcgtgttaccgaggttcatttcctgctcagaagcctc tccgatagtgacctcctggctatgaggcggcaaggccgctttctctgggagacttacttc tccactgctgacagtatttttaataccgtgctggctatgattaggactcgcatccagatc ccagccgctcccatccgggaagaggcggcagctgagatcccccaccgttcaggcaaggcg gctggaactgaccccaacatggctgacaacggggacctggacctggggccagtggagacg gagccgccctacgcctcacccagatacctccgcaatttcactctgactgtcactgacttt taccgcagctggaactgtgctccagggcctttccatcttttcccccacactccctttgac cctgtgttgccctcagaggccaaattcttgggctcagggactggctttcggcctattggt ggtggagctgggggttctggcaaggaatttcaggcagcgcttggaggcaatgttccccga gagcagttcacggtggtgatgttgacttatgagcgggaggaagtgcttatgaactcttta gagaggctgaatggcctcccttacctgaacaaggtcgtggtggtgtggaattctcccaag ctgccatcagaggaccttctgtggcctgacattggcgttcccatcatggtggtccgtact gagaagaacagtttgaacaaccgattcttaccctggaatgaaattgagacagaggccatc ctgtccattgatgacgatgctcacctccgccatgacgaaatcatgtttgggttccgggtg tggagagaagctcgggaccgcatcgtgggcttccctggccgttaccacgcatgggacatc ccccatcagtcctggctctacaactccaactactcctgtgagctgtccatggtgctgaca ggtgctgccttctttcacaagtattatgcctacctgtattcttatgtgatgccccaggcc atccgggacatggtggatgaatacatcaactgtgaggacattgccatgaacttccttgtc tcccacatcactcggaagccccccatcaaggtgacctcacggtggacattccgatgccca ggatgccctcaggccctgtctcatgatgactcccacttccacgagcggcacaagtgcatc aacttcttcgtgaaggtgtacggctacatgcccctcctgtacacgcagttcagggtggat tctgtgctcttcaagacacgcctgccccatgacaagaccaagtgcttcaagttcatctag |
Protein Sequence |
>2137 : length: 919 MTGYTMLRNGGAGNGGQTCMLRWSNRIRLTWLSFTLFVILVFFPLIAHYYLTTLDEADEA GKRIFGPRVGNELCEVKHVLDLCRIRESVSEELLQLEAKRQELNSEIAKLNLKIEACKKS IENAKQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLH NCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARANVYVTENADIACLYVI LVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQ STFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIESLRSSLQEA RSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGERED RLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWNE AALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTRIQI PAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFTLTVTDF YRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPR EQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRT EKNSLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDI PHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLV SHITRKPPIKVTSRWTFRCPGCPQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVD SVLFKTRLPHDKTKCFKFI |