Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2272

Name

FHIT

Synonym

AP3Aase|FRA3B;fragile histidine triad gene;FHIT;fragile histidine triad gene

Definition

AP3A hydrolase|bis(5'-adenosyl)-triphosphatase|diadenosine 5',5'''-P1,P3-triphosphate hydrolase|dinucleosidetriphosphatase|fragile histidine triad protein|tumor suppressor protein

Position

3p14.2

Gene Type

protein-coding

Source

Count: 4; Pubmed_search,TAG,UniProt,Generif

Literature support

Count: 26 PubMed records as below.

Evidence Status

Description

potential

"MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family."

potential

Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.

reviewed

tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

reviewed

Aberrant methylation of tumor suppressor genes in patients with refractory anemia with ring sideroblasts.

reviewed

Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients.

reviewed

Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit.

reviewed

"substrate binding, interaction with heat shock proteins, mitochondrial localization, and interaction with Fdxr are important for Fhit tumor suppressor function".

reviewed

These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription.

reviewed

"absence or poor expression of the Fhit protein in anal cancers suggests a role for this tumor suppressor gene product, as a risk factor, in the onset of this cancer, as reported before for other gastrointestinal tumors".

reviewed

Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.
More detail of all 26 literatures about FHIT

Pathways and Diseases

Pathway

Purine metabolism;KEGG PATHWAY;hsa00230

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Disease

ADHD;GAD

Disease

Epstein-Barr virus infection;FunDO

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Gastrointestinal tumor;FunDO

Disease

Cancer;FunDO

Disease

Oral cancer;FunDO

Disease

tumour kinetics and chromosomal instability;GAD

Disease

cervical cancer;GAD

Disease

Infection;FunDO

Disease

prostate cancer;GAD

Disease

Major depressive disorder;NHGRI

Disease

Attention deficit hyperactivity disorder;NHGRI

Disease

PSYCH;GAD

Disease

Non-small cell lung cancer;KEGG DISEASE;H00014

Disease

Penile disease;FunDO

Disease

CANCER;GAD

Disease

attention-deficit hyperactivity disorder;GAD

Disease

Cancers;KEGG DISEASE

Disease

major depressive disorder;GAD

Disease

Small cell lung cancer;KEGG DISEASE;H00013

Disease

Testicular dysfunction;FunDO

Disease

Congenital abnormality;FunDO

Disease

smoking;GAD

Disease

transcriptional inactivation of the FHIT gene;GAD

Disease

lung cancer and preneoplastic bronchial lesions;GAD

External Links

Links to Entrez Gene

2272

Links to all GeneRIF Items

2272

Links to iHOP

2272

Sequence Information

Nucleotide Sequence

>2272 : length: 444
atgtcgttcagatttggccaacatctcatcaagccctctgtagtgtttctcaaaacagaa
ctgtccttcgctcttgtgaataggaaacctgtggtaccaggacatgtccttgtgtgcccg
ctgcggccagtggagcgcttccatgacctgcgtcctgatgaagtggccgatttgtttcag
acgacccagagagtcgggacagtggtggaaaaacatttccatgggacctctctcaccttt
tccatgcaggatggccccgaagccggacagactgtgaagcacgttcacgtccatgttctt
cccaggaaggctggagactttcacaggaatgacagcatctatgaggagctccagaaacat
gacaaggaggactttcctgcctcttggagatcagaggaggaaatggcagcagaagccgca
gctctgcgggtctactttcagtga

Protein Sequence

>2272 : length: 147
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ



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