Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

231

Name

AKR1B1

Synonym

ADR|ALDR1|ALR2|AR;aldo-keto reductase family 1, member B1 (aldose reductase);AKR1B1;aldo-keto reductase family 1, member B1 (aldose reductase)

Definition

Lii5-2 CTCL tumor antigen|aldehyde reductase 1|aldo-keto reductase family 1 member B1|aldose reductase|low Km aldose reductase

Position

7q35

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

Aldose reductase gene was identified in the genome-wide loss-of-function genetic screen as putative tumor suppressor located at 7q35.
More detail of all 1 literatures about AKR1B1

Pathways and Diseases

Pathway

Fructose and mannose metabolism;KEGG PATHWAY;hsa00051

Pathway

Galactose metabolism;KEGG PATHWAY;hsa00052

Pathway

Hormone biosynthesis;Reactome;REACT:15314

Pathway

Pentose and glucuronate interconversions;KEGG PATHWAY;hsa00040

Pathway

methylglyoxal degradation III;BioCyc;PWY-5453

Pathway

Metabolic pathways;KEGG PATHWAY;hsa01100

Pathway

Glycerolipid metabolism;KEGG PATHWAY;hsa00561

Pathway

Pyruvate metabolism;KEGG PATHWAY;hsa00620

Pathway

Metabolism of lipids and lipoproteins;Reactome;REACT:22258

Pathway

Pregnenolone biosynthesis;PID Reactome;500773

Pathway

acetone degradation I (to methylglyoxal);BioCyc;PWY-5451

Disease

Ischemia;FunDO

Disease

Common cold;FunDO

Disease

retinopathy, diabetic;GAD

Disease

Diabetes mellitus;FunDO

Disease

RENAL;GAD

Disease

VISION;GAD

Disease

nephropathy in other diseases;GAD

Disease

Adrenal gland tumor;FunDO

Disease

METABOLIC;GAD

Disease

Pancreas disease;FunDO

Disease

Metabolism disease;FunDO

Disease

diabetes, type 2;GAD

Disease

Colon cancer;FunDO

Disease

Atherosclerosis;FunDO

External Links

Links to Entrez Gene

231

Links to all GeneRIF Items

231

Links to iHOP

231

Sequence Information

Nucleotide Sequence

>231 : length: 951
atggcaagccgtctcctgctcaacaacggcgccaagatgcccatcctggggttgggtacc
tggaagtcccctccagggcaggtgactgaggccgtgaaggtggccattgacgtcgggtac
cgccacatcgactgtgcccatgtgtaccagaatgagaatgaggtgggggtggccattcag
gagaagctcagggagcaggtggtgaagcgtgaggagctcttcatcgtcagcaagctgtgg
tgcacgtaccatgagaagggcctggtgaaaggagcctgccagaagacactcagcgacctg
aagctggactacctggacctctaccttattcactggccgactggctttaagcctgggaag
gaatttttcccattggatgagtcgggcaatgtggttcccagtgacaccaacattctggac
acgtgggcggccatggaagagctggtggatgaagggctggtgaaagctattggcatctcc
aacttcaaccatctccaggtggagatgatcttaaacaaacctggcttgaagtataagcct
gcagttaaccagattgagtgccacccatatctcactcaggagaagttaatccagtactgc
cagtccaaaggcatcgtggtgaccgcctacagccccctcggctctcctgacaggccctgg
gccaagcccgaggacccttctctcctggaggatcccaggatcaaggcgatcgcagccaag
cacaataaaactacagcccaggtcctgatccggttccccatgcagaggaacttggtggtg
atccccaagtctgtgacaccagaacgcattgctgagaactttaaggtctttgactttgaa
ctgagcagccaggatatgaccaccttactcagctacaacaggaactggagggtctgtgcc
ttgttgagctgtacctcccacaaggattaccccttccatgaagagttttga

Protein Sequence

>231 : length: 316
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF



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