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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 23136 |
Name | EPB41L3 |
Synonym | 4.1B|DAL-1|DAL1;erythrocyte membrane protein band 4.1-like 3;EPB41L3;erythrocyte membrane protein band 4.1-like 3 |
Definition | band 4.1-like protein 3|differentially expressed in adenocarcinoma of the lung protein 1 |
Position | 18p11.32 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 8 PubMed records as below. |
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Evidence Status |
Description |
reviewed | miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. |
reviewed | "Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma." |
reviewed | The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. |
potential | Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. |
reviewed | DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. |
reviewed | Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation. |
potential | "TSLC1 and DAL-1, two distinct tumor suppressor proteins, directly associate in lung cancer." |
reviewed | "Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas." |
| More detail of all 8 literatures about EPB41L3 | |
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Pathways and Diseases |
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Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
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External Links |
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Links to Entrez Gene | 23136 |
Links to all GeneRIF Items | 23136 |
Links to iHOP | 23136 |
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Sequence Information |
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Nucleotide Sequence |
>23136 : length: 3264 atgacgaccgaatctggatcagactcggaatccaagccggaccaggaggccgagccccag gaggcggcgggggcgcaggggcgcgcgggggcgcccgtgccggagccgcccaaggaggag cagcagcaggccctggagcagttcgccgccgctgcagcgcacagcaccccggtgcggagg gaggtcactgacaaggaacaggagtttgctgccagggctgcaaaacagctcgaatatcag caattagaagacgataaactttctcagaaatcatctagcagtaaactctctcggtctcca ttaaagattgtcaaaaagcctaaaagcatgcagtgcaaagtgatacttctcgatggatca gaatatacctgtgatgtagagaaacgctccagaggacaagtgctgtttgataaagtgtgt gaacacttgaacttgctagagaaagactactttgggcttacgtatcgagatgctgaaaac cagaagaattggttggaccctgctaaggaaataaaaaaacaggttcgaagtggtgcttgg cacttttcatttaatgtgaaattttatccaccagaccctgcccaactatctgaagatatc accaggtactacctctgcttgcagttgcgagatgacatcgtgtccggaaggctgccctgc tcctttgttaccctggccttgctgggctcctacactgtccagtcagagctcggagactat gacccagatgaatgtgggagcgattacattagtgagttccgctttgcaccaaaccacact aaagaactggaagacaaagtgatcgagctgcacaagagccacagaggaatgacgccagca gaagcagagatgcatttcttggaaaatgccaaaaaattatcaatgtatggggtagattta catcatgctaaggactcagaaggggtagaaattatgttaggagtttgtgcaagtggtctg ttgatatatcgcgaccggctgcgaataaacagatttgcctggcccaaggttctaaagatt tcatacaaacggaacaacttttacattaagatccggccgggagagtttgaacaatttgaa agcaccattgggtttaagctgccaaaccatcgagctgccaagcgtttatggaaagtatgt gttgagcatcatacatttttcagactactgttaccagaagcacctcccaagaaattccta accttgggttccaagtttcgttatagtggcaggacacaagcgcaaacgagaagagccagt gcgttgatagatcgcccagcaccttactttgaacgctcatccagcaaacgttataccatg tctcgcagcttggatggagaggttggtactggccagtacgccacaacaaaaggcatctct cagaccaacttgatcaccactgtgactccggagaagaaggctgaggaggagcgggacgag gaagaggacaaacggaggaagggggaagaagtcacgcccatctcggccatccggcacgag ggaaagtcacctgggcttggcactgactcatgtcccttgtcacccccatccacccattgt gcccccacatctcccacagagctccgtaggaggtgtaaggagaatgactgcaaactgcca ggttatgagccgtccagagctgagcacctgcctggagagcccgccttggactctgatggc ccagggaggccttacctaggggatcaagatgtggcttttagctacagacagcaaactggc aaggggaccaccctgttctccttctccttgcagctccctgagtcattcccctccctccta gatgatgatggatacctctctttccccaacctttctgaaaccaacctcctgccccagagc ttgcagcattacctcccgatccgctcaccgtcccttgtgccctgtttcctcttcatcttt ttctttctgctgtctgcctccttctcagtgccatacgctctcactctctccttccctctg gctctgtgcctctgctacctggagcccaaggcggcctccttgagcgcctccctagacaat gacccgagtgacagttcagaggaagagactgacagtgagcgcacggacaccgcagccgac ggggagaccaccgccactgagtcggaccaggaggaagatgcagagctcaaggcacaggag ctagaaaaaactcaagatgacctgatgaaacatcaaaccaacattagcgagctgaaaaga accttcttagaaacctcaacagacactgccgtaacgaatgaatgggagaagaggctttcc acctcccccgtgcgactggccgccaggcaggaggatgcccccatgatcgaaccacttgtc cctgaagagactaagcagtcttctggggaaaagctcatggatggctctgaaatcttcagt ttattagagtctgcgcgaaaaccaacagaattcataggaggggttacttctacttctcaa agctgggttcagaaaatggaaaccaagacggagtccagtggaatagagacggaacccacc gtgcaccacctgccgcttagcactgagaaggtggtgcaggagaccgtgttggtggaggag cggcgtgtggtgcacgcgagtggggatgcttcttactcggcgggagacagcggggatgct gcagcacagcccgcattcacaggcattaaagggaaagagggctctgccttgacggagggg gctaaagaggaaggaggggaggaggtcgctaaagctgtcctggaacaggaagagacagcc gctgcttcccgtgagcgacaagaggagcagagtgcagccatccacatttcagaaactttg gaacaaaaacctcattttgagtcctcaacggtgaagacggaaaccatcagttttggcagt gtttcaccgggaggagtaaagctagaaatttccacgaaggaagtgccagtagttcacacc gaaaccaaaaccatcacatatgaatcatcacaggtcgatccaggcacagatctggagcca ggcgtgctgatgagtgcacagacgatcacatctgaaaccaccagtaccaccaccactacg cacatcaccaaaactgtgaaagggggcatttcagagacaagaattgagaagcgaatagtc atcacgggggatgcagacattgaccatgaccaggcgctggctcaggcaattaaagaggcc aaagagcagcaccctgacatgtcagtgaccaaagtagtggtccataaagagacagagatc acaccagaagatggagaggattga |
Protein Sequence |
>23136 : length: 1087 MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAW HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL HHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRAS ALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLV PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI TPEDGED |