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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 23221 |
Name | RHOBTB2 |
Synonym | DBC2;Rho-related BTB domain containing 2;RHOBTB2;Rho-related BTB domain containing 2 |
Definition | deleted in breast cancer 2 gene protein|p83|rho-related BTB domain-containing protein 2 |
Position | 8p21.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 6 PubMed records as below. |
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Evidence Status |
Description |
reviewed | High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. |
potential | "DBC2, a candidate for a tumor suppressor gene involved in breast cancer." |
reviewed | "RhoBTB2 (DBC2) functions as tumor suppressor via inhibiting proliferation, preventing colony formation and inducing apoptosis in breast cancer cells." |
potential | RhoBTB2 is establishing itself as a tumor suppressor with increasing relevance towards malignancies. |
reviewed | A novel tumor suppressor gene RhoBTB2 (DBC2): frequent loss of expression in sporadic breast cancer. |
reviewed | Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function. |
| More detail of all 6 literatures about RHOBTB2 | |
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Pathways and Diseases |
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Pathway | Signaling by Rho GTPases;Reactome;REACT:11044 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
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External Links |
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Links to Entrez Gene | 23221 |
Links to all GeneRIF Items | 23221 |
Links to iHOP | 23221 |
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Sequence Information |
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Nucleotide Sequence |
>23221 : length: 2250 atgcaagcctggagaaaaggccccgatggcccccagaagacctcttcagacagcatgtcc cgtttaatggattctgacatggattatgaaaggccaaacgtagagaccatcaagtgcgtt gtggtgggggacaacgccgtgggtaagaccaggctcatctgtgcccgcgcttgcaatgcc accctcacccagtaccagctgctggccacgcatgtgcccacagtatgggccatcgaccaa tatcgtgtgtgccaggaggtgctggaacgctcccgagacgtggtagatgatgtcagcgtc tctctgcgcctctgggacacctttggagaccaccacaaagaccgtcgctttgcttatggg agatctgatgtggtggttctgtgcttctccattgccaaccccaattccctccaccatgtc aagaccatgtggtacccagaaatcaagcacttctgcccccgagcacctgtcatcttggtg ggctgccagttggacctgcgctacgctgacctggaggctgtcaacagggctaggcgaccc ttggctaggcccatcaaacctaatgaaatcctgcccccagagaagggtcgggaggtggcc aaggagctgggcatcccctactatgagaccagcgtggtggcccagttcggcatcaaggac gtctttgacaacgccatccgagctgcactcatctcccgccgccacctgcagttctggaag tcccacctccgcaatgtgcagcggcctctgctgcaggcacccttcctaccccccaagcca ccgcccccgatcatcgtggtgcccgaccctccctccagcagcgaggagtgccccgcccac ctcctggaggacccgctctgcgcggacgtcatcctggtgctgcaggagcgggtgcgcatc tttgcccacaagatctacctctccacctcttcctccaagttctatgacctgttcctcatg gacctgagtgagggggagctggggggcccctcggagccagggggcacccacccagaggac caccagggccactctgatcaacaccaccaccatcaccaccaccaccatgggcgagacttc ctgctccgagcagccagctttgacgtgtgcgagagcgtggatgaggctgggggctccggt cctgctggcctccgtgcttccaccagcgacgggatcttacggggcaacggaacagggtac ctaccgggcaggggtcgtgtgctgtcttcctggagccgagcttttgtgagcatccaggaa gagatggcagaagatcctctcacctacaaatcccggctgatggtggtggtgaagatggac agttccatccagccggggcccttccgggctgtcctcaagtacctgtacacgggggagcta gatgagaacgagcgtgacctcatgcacattgcccacattgctgagctgctcgaggtcttt gatctgcgcatgatggtggccaacattctcaacaatgaggccttcatgaaccaggagatc accaaggccttccacgtccgccggaccaaccgggttaaggagtgcttggcaaaaggcacc ttctcagatgtgaccttcatcctggatgatggcaccatcagcgcccacaagcccctgttg atttccagctgtgactggatggctgccatgtttggggggccatttgtggagagctccacc cgggaggtggtgtttccctacacaagcaagagctgcatgcgggccgtgctggaatacctc tacaccggcatgttcacctccagccccgacctggatgacatgaagctcatcattctagcc aaccgcctctgcctgccacacctggttgccctcacagagcagtacacagtgaccgggctg atggaagcgacccagatgatggtggacatcgatggggacgtccttgtgttcctggaactg gctcagttccactgtgcgtaccagctggccgactggtgtctccaccacatctgcaccaac tacaacaacgtgtgccgcaagttcccccgagacatgaaggccatgtccccagaaaaccag gagtatttcgagaagcatcggtggccacctgtgtggtacctgaaggaggaagatcattac cagcgggcacggaaggagcgtgagaaggaggactacctccacctcaagcggcagcccaaa cggcgttggctcttctggaacagtccatcctccccgtcttcctcggcagcctcctcctca tccccatcttcctcctcggctgtggtctga |
Protein Sequence |
>23221 : length: 749 MQAWRKGPDGPQKTSSDSMSRLMDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNA TLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYG RSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRP LARPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWK SHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEECPAHLLEDPLCADVILVLQERVRI FAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQHHHHHHHHHGRDF LLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRVLSSWSRAFVSIQE EMAEDPLTYKSRLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERDLMHIAHIAELLEVF DLRMMVANILNNEAFMNQEITKAFHVRRTNRVKECLAKGTFSDVTFILDDGTISAHKPLL ISSCDWMAAMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSSPDLDDMKLIILA NRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN YNNVCRKFPRDMKAMSPENQEYFEKHRWPPVWYLKEEDHYQRARKEREKEDYLHLKRQPK RRWLFWNSPSSPSSSAASSSSPSSSSAVV |