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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 23513 |
Name | SCRIB |
Synonym | CRIB1|SCRB1|SCRIB1|Vartul;scribbled homolog (Drosophila);SCRIB;scribbled homolog (Drosophila) |
Definition | protein scribble homolog |
Position | 8q24.3 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 12 PubMed records as below. |
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Evidence Status |
Description |
reviewed | "hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer." |
reviewed | tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. |
reviewed | Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction. |
reviewed | "hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis." |
reviewed | The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells. |
reviewed | Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells. |
reviewed | "Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli." |
potential | These results suggest that Scrib stabilizes the coupling between E-cadherin and the catenins and are consistent with the idea that mammalian Scrib could behave as a tumor suppressor by regulating epithelial cell adhesion and migration. |
reviewed | The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. |
potential | data establishs a potential link between the E-cadherin and hScrib tumor suppressors. |
| More detail of all 12 literatures about SCRIB | |
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External Links |
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Links to Entrez Gene | 23513 |
Links to all GeneRIF Items | 23513 |
Links to iHOP | 23513 |
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Sequence Information |
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Nucleotide Sequence |
>23513 : length: 4893 atgctcaagtgcatcccgctgtggcgctgcaaccggcacgtggagtcggtggacaagcgg cactgttcgctgcaggccgtgccggaggagatctaccgctacagccgcagcctggaggag ctgctgctcgacgccaaccagctgcgcgagctgcccaagccttttttccggctgctgaac ttgcgcaagctgggcctgagcgacaacgagatccagcggttgcctcccgaggtggccaac ttcatgcagctggtggagctggacgtgtcccggaacgatatccctgagatcccggagagc atcaagttctgcaaggctctggagatcgcggacttcagcgggaaccccctctccaggctc cctgatggcttcactcagctgcgcagcctggctcacctggccctgaatgatgtgtctctg caggcactgcccggggacgtgggcaacctcgccaacctggtgaccctggagctccgggag aacctgctcaagtccctgccagcgtccctgtcatttctggtcaagctggaacagctggat ctgggaggcaacgatctggaagtgctgccagacactctgggggctctgcccaatcttcgg gagctgtggcttgaccggaaccagctgtcagcactgcccccggagctcgggaacctgcgg cgcctggtgtgcctggacgtgtcggaaaaccggctggaggagctgcctgctgagctcggc gggctggtgctgctcactgacctgctgctgtcccagaacctgctgcggaggctgcccgac ggcatcggtcagctgaagcagctatccatcctaaaggtagaccagaatcggctgtgcgag gtgactgaggccatcggggactgtgagaacctctctgagctgatcctcacggagaacctg ctgatggccctgccccgctccctgggaaagctgactaagctgaccaacctcaacgtggac cggaaccacctcgaggcgctgccgcccgagatcgggggctgtgtggcactcagcgtcctc tccttgagggacaaccgcctggccgtcctgccaccagagctggcccacacgacagagctg cacgtgctggacgtggcggggaaccgcctgcagagtctgccgttcgcgctcacccacctc aatctcaaggccctgtggctggcagagaaccaggcgcagcccatgctccggttccagacg gaggatgatgcccggaccggcgagaaggtgctcacctgctacttgctgccccagcagccc ccactcagcctcgaggatgctgggcagcaggggagcctctcggagacctggagcgatgcc ccgccgagccgcgtcagcgtcatccagttcctggaggcccccataggtgatgaggacgct gaggaagctgcagctgagaagcggggcctacagcgccgggccacacctcaccccagcgag ctcaaggtgatgaagaggagcatcgaggggcggcggagcgaggcctgcccttgccagcca gactctgggtcgcccttgcctgcagaggaggagaagcggctgagtgccgagtctggcctg agtgaagactctcgcccatctgccagcacagtctctgaggctgagcccgagggcccgtcg gctgaggcacagggtgggagccagcaggaagccacgactgctggcggggaggaagacgcc gaagaggactaccaggagcccacggtgcatttcgcagaggacgcactgctgcccggggat gacagggagatcgaggaggggcagcctgaggccccctggaccctgccaggcgggaggcag cggctcatccgcaaggacacacctcactacaaaaagcacttcaagatctccaagctgccc cagcccgaggccgttgtggctctgctgcagggcatgcagcctgatggggagggccctgtg gctcccgggggctggcacaatggcccccacgcaccctgggctcctcgggcccagaaggag gaggaggaggaggaagagggtagtcctcaggaggaggaggaagaggaggaggaggaaaac agggctgaagaggaagaggccagcactgaggaggaggacaaggagggggccgtggtttct gcgccctctgtcaagggagtgtcgtttgaccaggccaataacctgctgatagagcctgct cgcattgaggaggaagagctgaccctcaccatcctgcggcagactgggggcctgggcatc agcattgcgggcggcaagggctccacaccctataagggggacgacgagggcatattcatc tctcgggtgtccgaggaaggccctgcggcccgggctggagtccgtgtgggtgacaagctc ctggaggtgaatggtgtggctctgcagggcgccgagcaccacgaggccgtggaggcgctc cggggggccggcactgccgtgcagatgcgagtgtggcgggagcgcatggtggagcctgag aacgcggtcaccatcacgccgctgcggcccgaggatgattacagcccccgagagcggcgg ggaggggggctgcgcctgcccctgctcccgcctgagagccccgggcccctccgtcagcgc cacgtggcctgcctggcacgcagcgagagggggctgggcttcagcattgctggtgggaaa ggctccacaccctacagggctggtgatgcgggcatcttcgtctcccgcattgccgagggc ggtgctgctcaccgcgcgggcacactgcaggttggcgaccgcgtcctctctattaatgga gtggacgtgactgaggccaggcatgaccacgccgtctccctgctgaccgctgcctccccc accatcgccctgctgttggagcgggaggctgggggccctcttcctcccagccctctgcca cattcctcaccccccaccgctgctgttgccaccaccagcataaccactgccacccccggg gtgcctgggttgccgagcctggcccccagcctgctggctgccgcgttggaagggccatac ccagtggaggagatccgtctgccaagagctgggggccctctggggcttagtattgtcgga ggctccgaccattccagccacccgtttggtgtccaggagcctggtgtgttcatctccaag gtgctcccgcggggcctggccgctcgcagcggcctgcgggttggggaccgcatcctggca gtgaacgggcaagacgtgcgggatgccacgcaccaagaagcagtcagtgccctgctccgg ccctgcctggagctgtcgctgctggtgcggagggacccggcacccccgggcctacgggaa ctgtgcatccagaaggcacctggggagaggctgggcatcagcatccgcgggggtgccagg ggccacgctggcaacccccgcgaccccacagacgagggcatcttcatctccaaggtgagc cccacgggggcagccgggcgcgacggtcggctgcgtgtgggtttgcggctgttggaggtg aaccagcagagcctgctgggcctgacgcacggcgaggcggtgcagctgctccgcagtgtg ggcgacaccctcaccgtgctggtctgtgacggcttcgaggccagcaccgacgcagccctg gaggtgtccccaggtgtcattgccaacccctttgcggcaggcatcggccaccggaacagc ctggagagcatctcttccatcgaccgggagctgagccctgagggcccaggcaaggagaag gagctgcctggacagaccctgcactgggggcccgaggccacagaagccgcaggtcggggt ctgcagcccctgaagctggactaccgcgccctggccgccgtgcccagcgctggcagcgtg cagagggtaccgtctggagcagctggagggaagatggctgaatctccctgctcccctagt ggccagcagccgccctccccgccttctccggatgagctgcccgccaatgtgaagcaggcc tacagggccttcgcggccgtgcccacttctcacccgcctgaggatgcccctgcccagccc cccacgcctgggcctgcagcctccccggagcagctgtccttccgggagcggcagaagtac tttgagctggaggtgcgcgtgccccaggccgagggcccccctaagcgcgtgtccctggtg ggtgctgacgacctgcggaagatgcaggaggaggaagccagaaaactacagcagaagaga gcgcagatgctgcgggaggcggcagaggctggggccgaagcgaggctcgccctggacggg gagacgctgggcgaggaggaacaggaggatgagcagccaccctgggccagcccgagcccc acctcaaggcagagcccggcgtcccccccgcccctgggaggtggcgccccggtgcggacg gccaaagctgaacggcgccaccaggagcggctgcgcgtgcagagtccggagccaccggca cccgagcgtgccctgtcccctgccgagctccgggccctggaggccgagaagcgtgcgctg tggagggcagccaggatgaagtcattggaacaggacgctctccgagcacagatggtcctc agcaggtcccaggaaggccggggcacgcgggggcccctggagcgactggccgaggcccct tcccctgcgcccaccccgtcgcccacccctgtggaagacctcggcccccagaccagcacc tccccgggacgcctgtcaccggactttgctgaggagttgaggtccctggaaccatctccc agccctggcccgcaggaggaggatggagaagtggctctggtgcttctgggcaggccctca cccggcgctgtgggccctgaagatgtggcactgtgcagcagccgccgccccgtaaggcct gggcgccgtggcctgggccctgtgccctcctag |
Protein Sequence |
>23513 : length: 1630 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP GRRGLGPVPS |