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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 257218 |
Name | SHPRH |
Synonym | bA545I5.2;SNF2 histone linker PHD RING helicase;SHPRH;SNF2 histone linker PHD RING helicase |
Definition | 2610103K11Rik|E3 ubiquitin-protein ligase SHPRH|SNF2, histone-linker, PHD and RING finger domain-containing helicase |
Position | 6q24.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | "We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress." |
potential | SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region. |
| More detail of all 2 literatures about SHPRH | |
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External Links |
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Links to Entrez Gene | 257218 |
Links to all GeneRIF Items | 257218 |
Links to iHOP | 257218 |
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Sequence Information |
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Nucleotide Sequence |
>257218 : length: 5052 atgagcagccgacggaaacgtgctcctccagtgagggtagatgaggaaaagaggcagcag cttcattggaatatgcatgaggacagaaggaatgaacctatcatcataagtgatgatgac gagcagccctgcccaggttcagatacctcttctgctcattatatcattctaagtgatagt ctaaaggaagaagtggctcacagagataagaagaggtgttcaaaagtggtgagcttctca aaaccaattgaaaaagaagagactgttggtattttttcccctttgtctgtaaagttaaat attgtgatttctccctatcattttgataattcctggaaagcatttctaggagaattaact cttcagcttcttcctgcacagagtttaattgaaaatttttccgaaaggagtattacattg atgagttcagagtcaagcaatcagttcctgatttatgttcattcaaaaggtgaagatgta gagaaacaaaaaaaagaaccgatgagtatttgtgacaagggtattctggtggagtcatcc ttcagtggtgaaatgttagaagatttggggtggctacaaaagaagagaagaataaaactc tatcagaaaccagaaggaaatcacattatcaaggttggaatttatcttttggaagctggc ctagcaaaactagacttcttgagtgatgcaaattcaagaatgaaaaagttcaatcagctc atgaagaaagtaatggaaaagttacacaattctattattccagatgtgttggaagaggat gaagatgatccggagagtgagccagagggacaagacattgacgagctgtatcactttgtg aaacaaacacatcagcaagaaacgcagtccatccaagtggatgtccagcatcctgcattg atccctgtgttgagaccctaccaaagagaggctgtcaattggatgctacaacaagagtgt ttcagaagcagtcctgctactgaaagtgccctgcacttcttatggcgagagattgttaca tctgagggtctgaaactctactataatccatatacaggctgcatcattcgtgagtaccca aattctgggccgcagttgcttggtggaattttagcagatgagatgggtcttggaaagaca gtggaggttttggctctgattctgacacatactcgacaagatgtcaagcaagatgctctc actcttcccgagggaaaagtggtgaattattttattccgtcacattattttggaggaaaa ctgaaaaagacagaaatccagaatatcgaatttgaaccaaaagaaaaagttcaatgccct cctacacgtgtgatgatactgacagctgtgaaagaaatgaatggaaaaaaaggagtgtcc atcctttccatctataagtatgtcagttctatatatagatacgatgttcaacggaacagg agtcttttgaaacggatgctgaaatgtttaatttttgaaggtctcgtgaaacagatcaaa ggccatggtttttctgggacttttacattgggaaagaattacaaggaagaggatatatgt gataaaacaaaaaagcaggcagtagggagtccaaggaaaattcagaaagaaactagaaaa tcagggaacaaggacacagattctgaatacttgccatcagacacctctgatgatgatgat gatccttactattattattataagtccaggagaaatcgcagtaaattgaggaaaaagctt gttccatccacaaaaaaaggaaaaagtcaaccatttatcaatcccgattcacaaggtcac tgtccagctactagcgactctggaataactgatgttgctatgtctaaaagtacatgtatc tctgaattcaaccaagaacatgaaacagaggactgtgctgaatctctaaatcatgctgat agtgatgtaccaccttctaataccatgagtccctttaacacctctgattaccgctttgag tgtatatgtggtgaacttgatcagatagatcgtaagcctcgtgttcaatgcctgaagtgt cacctgtggcaacatgcaaagtgtgtgaattatgatgagaaaaatctgaagatcaagcct ttttactgcccccactgccttgttgcaatggaaccagtgtcaacaagagcaactctgatc atctctccaagttccatctgtcaccagtgggtggatgagatcaacaggcatgtgaggtcg tcatctcttcgagtcttggtatatcaaggagtgaagaaagatggctttttacaacctcat tttttggcagaacaggatatagttatcattacctatgatgtactgcgttcagaattaaat tatgtcgatatcccacatagcaatagtgaggatgggcgtcgcctacggaaccagaagcgc tatatggctatcccgagccccctggtagctgtggagtggtggaggatctgccttgatgaa gctcagatggttgagtgtcccacagtaaaagctgcagaaatggcccagcgtttgagtggg attaatcgatggtgtatcagtggcactccagtacagagaggattagaggatctttttggg ttagtggtctttcttggtattgaaccttactgtgtcaaacactggtgggttcgacttctc tatcggccttactgcaagaagaatcctcagcatctctacagctttattgccaagatactg tggaggtctgcaaagaaagatgtgattgaccaaatccaaataccaccacaaaccgaagaa atacactggctccacttttctccagtggaaaggcatttctatcaccgtcagcatgaggtg tgctgccaggatgtggtggtaaaactcaggaagatttctgactgggctctgaagctcagc agcctagacagaaggactgtcacctctatcctgtatccattgctgaggctcagacaggcc tgctgtcacccacaggctgttcgtggagagttcttgccactccaaaaaagcaccatgaca atggaagagctgctgacatctttgcagaagaaatgtggaactgaatgtgaagaagcacat cgacagctagtttgtgctctcaatggcttagcaggcattcatattattaaaggtgagtat gccttggcagcagaattgtacagagaagtgttgcgctcctcggaggaacacaaaggaaaa ctcaaaactgattcacttcaaagacttcatgctacccataacttgatggaattgttgata gccaggcacccagggataccacctaccttgcgtgatggccgacttgaggaagaggccaaa cagctgcgagagcactacatgagcaagtgtaatacagaagttgctgaagcccagcaagct ttatatcctgtgcagcagaccatccatgagcttcaaagaaagattcattctaattctcct tggtggctaaatgtgatccacagagcaatagaatttactattgatgaggagctagttcag cgagtgcgaaatgaaataaccagcaactacaagcaacaaactggcaagctttctatgtca gagaagttccgtgattgcagaggtcttcagttcttacttacaacacaaatggaagagcta aataaatgccagaagctagtaagagaggctgtaaaaaacctggagggacctccatctcgt aatgttattgagtctgcaacagtctgtcacctccgaccagccagacttcctctcaactgc tgtgtcttttgtaaagctgatgaattgttcacagagtatgaatcaaagctattttccaac acagtcaaaggccagactgcaatatttgaggagatgatagaagatgaagaaggactggtg gatgatcgagcacctaccaccacccggggtctctgggcaataagtgagacagagcgatct atgaaagcaatactatcatttgcaaaatcacataggtttgatgttgaatttgttgatgaa ggaagcacttcaatggatctctttgaagcatggaagaaggaatataagttgcttcatgaa tattggatggctctgaggaatcgtgtgtctgctgttgatgaacttgcaatggctacagaa cgactaagagtgcgtgatcctagggagccaaagcctaatccgcctgttcttcatatcatt gaaccacatgaggtagaacaaaaccgaataaaactactaaatgataaagctgttgctaca tcacagcttcagaaaaaacttgggcagcttctttacctaactaatttggagaagtctcaa gataaaacatcgggaggtgttaatccagaaccttgcccaatctgtgctcgacagctagga aaacagtgggcggtactgacctgtggtcactgtttctgtaatgaatgcatttctataatt attgaacaatacagcgtgggatctcacagaagctccattaagtgtgcaatctgccgccag accacatctcacaaagaaatctcgtatgtctttacctcagagaaagcaaaccaggaggag gacatccctgtgaagggcagccattctacaaaagtggaagctgtggtcagaactctgatg aaaatacagcttagagatccaggggccaaagcactcgttttctcaacgtggcaagatgta ttagatattatttcaaaagctcttactgacaacaacatggaatttgcacaaatcagtcgt gttaagacatttcaggagaacctttcagcatttaaacgtgatccccaaatcaatattttg ctgctgcccctgcacacaggttctaatggattaactatcattgaagcaactcatgttctc ttggtggagcccatattgaaccctgcccatgagcttcaggccatagggagggtgcaccga attggacagacaaaacctactattgtacacagattcttaattaaagcaacaatagaagaa agaatgcaggcaatgctgaaaactgctgagagaagtcacacgaactcatcagcaaagcat tcagaggcctctgtcttgactgtggctgacctggcagacctatttaccaaagaaactgaa gagcttgaatga |
Protein Sequence |
>257218 : length: 1683 MSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDS LKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELT LQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPMSICDKGILVESS FSGEMLEDLGWLQKKRRIKLYQKPEGNHIIKVGIYLLEAGLAKLDFLSDANSRMKKFNQL MKKVMEKLHNSIIPDVLEEDEDDPESEPEGQDIDELYHFVKQTHQQETQSIQVDVQHPAL IPVLRPYQREAVNWMLQQECFRSSPATESALHFLWREIVTSEGLKLYYNPYTGCIIREYP NSGPQLLGGILADEMGLGKTVEVLALILTHTRQDVKQDALTLPEGKVVNYFIPSHYFGGK LKKTEIQNIEFEPKEKVQCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSIYRYDVQRNR SLLKRMLKCLIFEGLVKQIKGHGFSGTFTLGKNYKEEDICDKTKKQAVGSPRKIQKETRK SGNKDTDSEYLPSDTSDDDDDPYYYYYKSRRNRSKLRKKLVPSTKKGKSQPFINPDSQGH CPATSDSGITDVAMSKSTCISEFNQEHETEDCAESLNHADSDVPPSNTMSPFNTSDYRFE CICGELDQIDRKPRVQCLKCHLWQHAKCVNYDEKNLKIKPFYCPHCLVAMEPVSTRATLI ISPSSICHQWVDEINRHVRSSSLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELN YVDIPHSNSEDGRRLRNQKRYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSG INRWCISGTPVQRGLEDLFGLVVFLGIEPYCVKHWWVRLLYRPYCKKNPQHLYSFIAKIL WRSAKKDVIDQIQIPPQTEEIHWLHFSPVERHFYHRQHEVCCQDVVVKLRKISDWALKLS SLDRRTVTSILYPLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAH RQLVCALNGLAGIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLI ARHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALYPVQQTIHELQRKIHSNSP WWLNVIHRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKFRDCRGLQFLLTTQMEEL NKCQKLVREAVKNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSN TVKGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAILSFAKSHRFDVEFVDE GSTSMDLFEAWKKEYKLLHEYWMALRNRVSAVDELAMATERLRVRDPREPKPNPPVLHII EPHEVEQNRIKLLNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGVNPEPCPICARQLG KQWAVLTCGHCFCNECISIIIEQYSVGSHRSSIKCAICRQTTSHKEISYVFTSEKANQEE DIPVKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFAQISR VKTFQENLSAFKRDPQINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHR IGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTNSSAKHSEASVLTVADLADLFTKETE ELE |