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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 26038 |
Name | CHD5 |
Synonym | -;chromodomain helicase DNA binding protein 5;CHD5;chromodomain helicase DNA binding protein 5 |
Definition | ATP-dependent helicase CHD5|CHD-5|chromodomain-helicase-DNA-binding protein 5 |
Position | 1p36.31 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 6 PubMed records as below. |
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Evidence Status |
Description |
reviewed | data suggest that CHD5 is a tumor suppressor gene that is epigenetically downregulated in laryngeal squamous cell carcinoma. |
reviewed | CHD5 is a tumor suppressor gene epigenetically down-regulated in gastric cancer. |
reviewed | study demonstrated the existence of somatic mutations and methylation of CHD5 in primary epithelial ovarian cancers; CHD5 may play a role as a tumor suppressor gene in ovarian cancer. |
potential | "CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism." |
reviewed | A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. [REVIEW]. |
reviewed | Study demonstrates that Chd5 functions as a tumor suppressor in vivo and implicates deletion of CHD5 in human cancer. |
| More detail of all 6 literatures about CHD5 | |
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External Links |
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Links to Entrez Gene | 26038 |
Links to all GeneRIF Items | 26038 |
Links to iHOP | 26038 |
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Sequence Information |
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Nucleotide Sequence |
>26038 : length: 5865 atgcggggcccagtgggcaccgaggaggagctgccgcggctgttcgccgaggagatggag aatgaggacgagatgtcagaagaagaagatggtggtcttgaagccttcgatgactttttc cctgtggagcccgtgagccttcctaagaagaagaaacccaagaagctcaaggaaaacaag tgtaaagggaagcggaagaagaaagaggggagcaatgatgagctatcagagaatgaagag gatctggaagagaagtcggagagtgaaggcagtgactactccccgaataaaaagaagaag aagaaactcaaggacaagaaggagaaaaaagccaagcgaaaaaagaaggatgaggatgag gatgataatgatgatggatgcttaaaggagcccaagtcctcggggcagctcatggccgag tggggcctggacgacgtggactacctgttctcggaggaggattaccacacgctgaccaac tacaaggccttcagccagttcctcaggccactcattgccaagaagaacccgaagatcccc atgtccaaaatgatgaccgtcctgggtgccaagtggcgggagttcagcgccaacaacccc ttcaagggcagctccgcggcagcagcggcggcggcggtggctgcggctgtagagacggtc accatctcccctccgctagccgtcagccccccgcaggtgccccagcctgtgcctatccgc aaggccaagaccaaggagggcaaagggcctggagtgaggaagaagatcaaaggctccaaa gatgggaagaaaaagggcaaagggaaaaagacggccgggctcaagttccgcttcgggggg atcagcaacaagaggaagaaaggctcctcgagtgaagaagatgagagggaggagtcggac ttcgacagcgccagcatccacagtgcctccgtgcgctccgaatgctctgcagccctgggc aagaagagcaagaggaggcgcaagaagaagaggattgatgatggtgacggctatgagaca gaccaccaggattactgtgaggtgtgccagcagggtggggagatcatcctgtgcgacacc tgcccgagggcctaccatctcgtatgcctggacccagagctggagaaggctcccgagggc aagtggagctgcccccactgtgagaaggaggggatccagtgggagccgaaggacgacgac gatgaagaggaggagggcggctgcgaggaggaggaggacgaccacatggagttctgccgc gtgtgcaaggacgggggcgagctgctctgctgcgacgcctgcccctcctcctaccacctg cattgcctcaacccgccgctgcccgagatcccaaacggtgaatggctctgcccgcgctgt acttgccccccactgaagggcaaagtccagcggattctacactggaggtggacggagccc cctgcccccttcatggtggggctgccggggcctgacgtggagcccagcctccctccacct aagcccctggagggcatccctgagagagagttctttgtcaagtgggcagggctgtcctac tggcattgctcctgggtgaaggagctacagctggagctgtaccacacggtgatgtatcgc aactaccaaagaaagaacgacatggatgagccgcccccctttgactacggctctggggat gaagacggcaagagcgagaagaggaagaacaaggaccccctctatgccaagatggaggag cgcttctaccgctatggcatcaagccagagtggatgatgattcaccgaatcctgaaccat agctttgacaagaagggggatgtgcactacctgatcaagtggaaagacctgccctacgac cagtgcacctgggagatcgatgacatcgacatcccctactacgacaacctcaagcaggcc tactggggccacagggagctgatgctgggagaagacaccaggctgcccaagaggctgctc aagaagggcaagaagctgagggacgacaagcaggagaagccgccggacacgcccattgtg gaccccacggtcaagttcgacaagcagccatggtacatcgactccacaggcggcacactg cacccgtaccagctggagggcctcaactggctgcgcttctcttgggcccagggcactgac accatcctggccgatgagatgggtctgggcaagacggtgcagaccatcgtgttcctttac tccctctacaaggagggccactccaaagggccctacctggttagcgcgcccctctccacc atcatcaactgggaacgcgagtttgagatgtgggcgcccgacttctacgtggtcacctac acgggggacaaggagagccgctcggtgattcgggagaacgagttttcctttgaggacaac gccattcggagtgggaagaaggtattccgtatgaagaaagaagtgcagatcaaattccac gtgctgctcacctcctatgagctcatcaccattgaccaggccatcctgggctccatcgag tgggcctgcctggtggtagatgaggcccaccgcctcaagaacaaccagtccaagtttttt agggtcttaaacagctacaagattgattacaagctgctgctgacagggaccccccttcag aacaacctggaggagctgttccatctcctcaacttcctgactccagagaggttcaacaac ctggagggcttcctggaggagtttgctgacatctccaaggaagaccagatcaagaagctg catgacctgctggggccgcacatgctcaggcggctcaaggctgacgtgttcaagaacatg ccggccaagaccgagctcattgtccgggtggagctgagccagatgcagaagaagtactac aagttcatcctcacacggaactttgaggcactgaactccaaggggggcgggaaccaagta tcgctgctcaacatcatgatggacctgaaaaagtgctgcaaccacccctacctcttccct gtggctgccgtggaggcccctgtcttgcccaatggctcctacgatggaagctccctggtc aagtcttcagggaagctcatgctgctacagaagatgctgaagaaactgcgggatgagggg caccgtgtgctcatcttctcccagatgaccaagatgctggacctcctggaggacttcctg gagtacgaaggctacaagtatgagcggattgatggtggcatcaccgggggcctccggcag gaggcaatcgacagattcaatgcccccggggcccagcagttctgcttcctcctctcaacc cgggcaggtggtctgggcatcaacctggccacggcggacactgtcatcatctacgactcg gactggaacccgcacaatgacatccaggccttcagccgcgcccaccgcatcggccagaac aagaaggtgatgatctaccgcttcgtgactcgggcctcggtggaggagcgcatcacgcag gtggccaagcgcaagatgatgctcacccacctggtggtgcggcccggcctcggctccaag tcggggtccatgaccaagcaggagctggacgacatcctcaagttcggcacggaggaactc ttcaaggacgacgtggagggcatgatgtctcagggccagaggccggtcacacccatccct gatgtccagtcctccaaaggggggaacttggccgccagtgcaaagaagaagcacggtagc accccgccaggtgacaacaaggacgtggaggacagcagtgtgatccactatgacgatgcg gccatctccaagctgctggaccggaaccaggacgctacagatgacacggagctacagaac atgaacgagtacctgagctccttcaaggtggcgcagtacgtggtgcgcgaggaggacggc gtggaggaggtggagcgggaaatcatcaagcaggaggagaacgtggaccccgactactgg gagaagctgctgcggcaccactatgagcagcagcaggaggacctggcccgcaacctgggc aagggcaagcgcatccgcaagcaggtcaactacaacgatgcctcccaggaggaccaggag tggcaggatgagctctctgataaccagtcagaatattccattggctctgaggatgaggat gaggactttgaagagaggccggaagggcagagtggacgacgacaatcccggaggcagctg aagagtgacagggacaagcccctgcccccgcttctcgcccgagttggtggcaacatcgag gtgctgggcttcaatgcccgacagcggaaggcctttctgaacgccatcatgcgctggggc atgcccccgcaggacgccttcaactcccactggctggtgcgggaccttcgagggaagagc gagaaggagtttagagcctatgtgtccctcttcatgcggcacctgtgtgagccgggggcg gatggtgcagagaccttcgcagacggcgtgccccgggagggcctctccaggcagcacgtg ctgacccgcatcggggtcatgtcactagttaggaagaaggttcaggagtttgagcatgtc aacgggaagtacagcaccccagacttgatccctgaggggcccgaggggaagaagtcgggc gaggtgatctcctcggaccccaacacaccagtgcccgccagccctgcccacctcctgcca gccccgctgggcctgccagacaaaatggaagcccagctgggctacatggatgagaaagac cccggggcacagaagccaaggcagcccctggaagtccaggcccttccagccgccttggat agagtggagagtgaggacaagcacgagagcccagccagcaaggagagagcccgagaggag cggccagaggagacggagaaggccccgccctccccggagcagctgccgagagaggaggtg cttcctgagaaggagaagatcctggacaagctggagctgagcttgatccacagcagaggg gacagttccgaactcaggccagatgacaccaaggctgaggagaaggagcccattgaaaca cagcaaaatggtgacaaagaggaagatgacgaggggaagaaggaggacaagaaggggaaa ttcaagttcatgttcaacatcgcggacgggggcttcacggagttgcacacgctgtggcag aacgaggagcgggctgctgtatcctctgggaaaatctacgacatctggcaccggcgccat gactactggctgctggcgggcatcgtgacgcacggctacgcccgctggcaggacatccag aatgacccacggtacatgatcctcaacgagcccttcaagtctgaggtccacaagggcaac tacctggagatgaagaacaagttcctggcccgcaggtttaagctgctggagcaggcgttg gtcattgaggagcagctccggagggccgcgtacctgaacatgacgcaggaccccaaccac cccgccatggccctcaacgcccgcctggctgaagtggagtgcctcgccgagagccaccag cacctgtccaaggagtcccttgctgggaacaagcctgccaatgccgtcctgcacaaggtc ctgaaccagctggaggagctgctgagcgacatgaaggccgacgtgacccggctgccatcc atgctgtcccgcatccccccggtggccgcccggctgcagatgtcggagcgcagcatcctg agccgcctgaccaaccgcgccggggaccccaccatccagcagggcgctttcggctcctcc cagatgtacagcaacaactttgggcccaacttccggggccctggaccgggagggattgtc aactacaaccagatgcccctggggccctatgtgaccgatatctag |
Protein Sequence |
>26038 : length: 1954 MRGPVGTEEELPRLFAEEMENEDEMSEEEDGGLEAFDDFFPVEPVSLPKKKKPKKLKENK CKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKKAKRKKKDEDE DDNDDGCLKEPKSSGQLMAEWGLDDVDYLFSEEDYHTLTNYKAFSQFLRPLIAKKNPKIP MSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTISPPLAVSPPQVPQPVPIR KAKTKEGKGPGVRKKIKGSKDGKKKGKGKKTAGLKFRFGGISNKRKKGSSSEEDEREESD FDSASIHSASVRSECSAALGKKSKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDT CPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCR VCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEP PAPFMVGLPGPDVEPSLPPPKPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYR NYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMIHRILNH SFDKKGDVHYLIKWKDLPYDQCTWEIDDIDIPYYDNLKQAYWGHRELMLGEDTRLPKRLL KKGKKLRDDKQEKPPDTPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTD TILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTY TGDKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIE WACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNN LEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYY KFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLV KSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQ EAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQN KKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEEL FKDDVEGMMSQGQRPVTPIPDVQSSKGGNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDA AISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREIIKQEENVDPDYW EKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDED EDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWG MPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHV LTRIGVMSLVRKKVQEFEHVNGKYSTPDLIPEGPEGKKSGEVISSDPNTPVPASPAHLLP APLGLPDKMEAQLGYMDEKDPGAQKPRQPLEVQALPAALDRVESEDKHESPASKERAREE RPEETEKAPPSPEQLPREEVLPEKEKILDKLELSLIHSRGDSSELRPDDTKAEEKEPIET QQNGDKEEDDEGKKEDKKGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRH DYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLARRFKLLEQAL VIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKV LNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSS QMYSNNFGPNFRGPGPGGIVNYNQMPLGPYVTDI |