Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

26038

Name

CHD5

Synonym

-;chromodomain helicase DNA binding protein 5;CHD5;chromodomain helicase DNA binding protein 5

Definition

ATP-dependent helicase CHD5|CHD-5|chromodomain-helicase-DNA-binding protein 5

Position

1p36.31

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 6 PubMed records as below.

Evidence Status

Description

reviewed

data suggest that CHD5 is a tumor suppressor gene that is epigenetically downregulated in laryngeal squamous cell carcinoma.

reviewed

CHD5 is a tumor suppressor gene epigenetically down-regulated in gastric cancer.

reviewed

study demonstrated the existence of somatic mutations and methylation of CHD5 in primary epithelial ovarian cancers; CHD5 may play a role as a tumor suppressor gene in ovarian cancer.

potential

"CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism."

reviewed

A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. [REVIEW].

reviewed

Study demonstrates that Chd5 functions as a tumor suppressor in vivo and implicates deletion of CHD5 in human cancer.
More detail of all 6 literatures about CHD5

External Links

Links to Entrez Gene

26038

Links to all GeneRIF Items

26038

Links to iHOP

26038

Sequence Information

Nucleotide Sequence

>26038 : length: 5865
atgcggggcccagtgggcaccgaggaggagctgccgcggctgttcgccgaggagatggag
aatgaggacgagatgtcagaagaagaagatggtggtcttgaagccttcgatgactttttc
cctgtggagcccgtgagccttcctaagaagaagaaacccaagaagctcaaggaaaacaag
tgtaaagggaagcggaagaagaaagaggggagcaatgatgagctatcagagaatgaagag
gatctggaagagaagtcggagagtgaaggcagtgactactccccgaataaaaagaagaag
aagaaactcaaggacaagaaggagaaaaaagccaagcgaaaaaagaaggatgaggatgag
gatgataatgatgatggatgcttaaaggagcccaagtcctcggggcagctcatggccgag
tggggcctggacgacgtggactacctgttctcggaggaggattaccacacgctgaccaac
tacaaggccttcagccagttcctcaggccactcattgccaagaagaacccgaagatcccc
atgtccaaaatgatgaccgtcctgggtgccaagtggcgggagttcagcgccaacaacccc
ttcaagggcagctccgcggcagcagcggcggcggcggtggctgcggctgtagagacggtc
accatctcccctccgctagccgtcagccccccgcaggtgccccagcctgtgcctatccgc
aaggccaagaccaaggagggcaaagggcctggagtgaggaagaagatcaaaggctccaaa
gatgggaagaaaaagggcaaagggaaaaagacggccgggctcaagttccgcttcgggggg
atcagcaacaagaggaagaaaggctcctcgagtgaagaagatgagagggaggagtcggac
ttcgacagcgccagcatccacagtgcctccgtgcgctccgaatgctctgcagccctgggc
aagaagagcaagaggaggcgcaagaagaagaggattgatgatggtgacggctatgagaca
gaccaccaggattactgtgaggtgtgccagcagggtggggagatcatcctgtgcgacacc
tgcccgagggcctaccatctcgtatgcctggacccagagctggagaaggctcccgagggc
aagtggagctgcccccactgtgagaaggaggggatccagtgggagccgaaggacgacgac
gatgaagaggaggagggcggctgcgaggaggaggaggacgaccacatggagttctgccgc
gtgtgcaaggacgggggcgagctgctctgctgcgacgcctgcccctcctcctaccacctg
cattgcctcaacccgccgctgcccgagatcccaaacggtgaatggctctgcccgcgctgt
acttgccccccactgaagggcaaagtccagcggattctacactggaggtggacggagccc
cctgcccccttcatggtggggctgccggggcctgacgtggagcccagcctccctccacct
aagcccctggagggcatccctgagagagagttctttgtcaagtgggcagggctgtcctac
tggcattgctcctgggtgaaggagctacagctggagctgtaccacacggtgatgtatcgc
aactaccaaagaaagaacgacatggatgagccgcccccctttgactacggctctggggat
gaagacggcaagagcgagaagaggaagaacaaggaccccctctatgccaagatggaggag
cgcttctaccgctatggcatcaagccagagtggatgatgattcaccgaatcctgaaccat
agctttgacaagaagggggatgtgcactacctgatcaagtggaaagacctgccctacgac
cagtgcacctgggagatcgatgacatcgacatcccctactacgacaacctcaagcaggcc
tactggggccacagggagctgatgctgggagaagacaccaggctgcccaagaggctgctc
aagaagggcaagaagctgagggacgacaagcaggagaagccgccggacacgcccattgtg
gaccccacggtcaagttcgacaagcagccatggtacatcgactccacaggcggcacactg
cacccgtaccagctggagggcctcaactggctgcgcttctcttgggcccagggcactgac
accatcctggccgatgagatgggtctgggcaagacggtgcagaccatcgtgttcctttac
tccctctacaaggagggccactccaaagggccctacctggttagcgcgcccctctccacc
atcatcaactgggaacgcgagtttgagatgtgggcgcccgacttctacgtggtcacctac
acgggggacaaggagagccgctcggtgattcgggagaacgagttttcctttgaggacaac
gccattcggagtgggaagaaggtattccgtatgaagaaagaagtgcagatcaaattccac
gtgctgctcacctcctatgagctcatcaccattgaccaggccatcctgggctccatcgag
tgggcctgcctggtggtagatgaggcccaccgcctcaagaacaaccagtccaagtttttt
agggtcttaaacagctacaagattgattacaagctgctgctgacagggaccccccttcag
aacaacctggaggagctgttccatctcctcaacttcctgactccagagaggttcaacaac
ctggagggcttcctggaggagtttgctgacatctccaaggaagaccagatcaagaagctg
catgacctgctggggccgcacatgctcaggcggctcaaggctgacgtgttcaagaacatg
ccggccaagaccgagctcattgtccgggtggagctgagccagatgcagaagaagtactac
aagttcatcctcacacggaactttgaggcactgaactccaaggggggcgggaaccaagta
tcgctgctcaacatcatgatggacctgaaaaagtgctgcaaccacccctacctcttccct
gtggctgccgtggaggcccctgtcttgcccaatggctcctacgatggaagctccctggtc
aagtcttcagggaagctcatgctgctacagaagatgctgaagaaactgcgggatgagggg
caccgtgtgctcatcttctcccagatgaccaagatgctggacctcctggaggacttcctg
gagtacgaaggctacaagtatgagcggattgatggtggcatcaccgggggcctccggcag
gaggcaatcgacagattcaatgcccccggggcccagcagttctgcttcctcctctcaacc
cgggcaggtggtctgggcatcaacctggccacggcggacactgtcatcatctacgactcg
gactggaacccgcacaatgacatccaggccttcagccgcgcccaccgcatcggccagaac
aagaaggtgatgatctaccgcttcgtgactcgggcctcggtggaggagcgcatcacgcag
gtggccaagcgcaagatgatgctcacccacctggtggtgcggcccggcctcggctccaag
tcggggtccatgaccaagcaggagctggacgacatcctcaagttcggcacggaggaactc
ttcaaggacgacgtggagggcatgatgtctcagggccagaggccggtcacacccatccct
gatgtccagtcctccaaaggggggaacttggccgccagtgcaaagaagaagcacggtagc
accccgccaggtgacaacaaggacgtggaggacagcagtgtgatccactatgacgatgcg
gccatctccaagctgctggaccggaaccaggacgctacagatgacacggagctacagaac
atgaacgagtacctgagctccttcaaggtggcgcagtacgtggtgcgcgaggaggacggc
gtggaggaggtggagcgggaaatcatcaagcaggaggagaacgtggaccccgactactgg
gagaagctgctgcggcaccactatgagcagcagcaggaggacctggcccgcaacctgggc
aagggcaagcgcatccgcaagcaggtcaactacaacgatgcctcccaggaggaccaggag
tggcaggatgagctctctgataaccagtcagaatattccattggctctgaggatgaggat
gaggactttgaagagaggccggaagggcagagtggacgacgacaatcccggaggcagctg
aagagtgacagggacaagcccctgcccccgcttctcgcccgagttggtggcaacatcgag
gtgctgggcttcaatgcccgacagcggaaggcctttctgaacgccatcatgcgctggggc
atgcccccgcaggacgccttcaactcccactggctggtgcgggaccttcgagggaagagc
gagaaggagtttagagcctatgtgtccctcttcatgcggcacctgtgtgagccgggggcg
gatggtgcagagaccttcgcagacggcgtgccccgggagggcctctccaggcagcacgtg
ctgacccgcatcggggtcatgtcactagttaggaagaaggttcaggagtttgagcatgtc
aacgggaagtacagcaccccagacttgatccctgaggggcccgaggggaagaagtcgggc
gaggtgatctcctcggaccccaacacaccagtgcccgccagccctgcccacctcctgcca
gccccgctgggcctgccagacaaaatggaagcccagctgggctacatggatgagaaagac
cccggggcacagaagccaaggcagcccctggaagtccaggcccttccagccgccttggat
agagtggagagtgaggacaagcacgagagcccagccagcaaggagagagcccgagaggag
cggccagaggagacggagaaggccccgccctccccggagcagctgccgagagaggaggtg
cttcctgagaaggagaagatcctggacaagctggagctgagcttgatccacagcagaggg
gacagttccgaactcaggccagatgacaccaaggctgaggagaaggagcccattgaaaca
cagcaaaatggtgacaaagaggaagatgacgaggggaagaaggaggacaagaaggggaaa
ttcaagttcatgttcaacatcgcggacgggggcttcacggagttgcacacgctgtggcag
aacgaggagcgggctgctgtatcctctgggaaaatctacgacatctggcaccggcgccat
gactactggctgctggcgggcatcgtgacgcacggctacgcccgctggcaggacatccag
aatgacccacggtacatgatcctcaacgagcccttcaagtctgaggtccacaagggcaac
tacctggagatgaagaacaagttcctggcccgcaggtttaagctgctggagcaggcgttg
gtcattgaggagcagctccggagggccgcgtacctgaacatgacgcaggaccccaaccac
cccgccatggccctcaacgcccgcctggctgaagtggagtgcctcgccgagagccaccag
cacctgtccaaggagtcccttgctgggaacaagcctgccaatgccgtcctgcacaaggtc
ctgaaccagctggaggagctgctgagcgacatgaaggccgacgtgacccggctgccatcc
atgctgtcccgcatccccccggtggccgcccggctgcagatgtcggagcgcagcatcctg
agccgcctgaccaaccgcgccggggaccccaccatccagcagggcgctttcggctcctcc
cagatgtacagcaacaactttgggcccaacttccggggccctggaccgggagggattgtc
aactacaaccagatgcccctggggccctatgtgaccgatatctag

Protein Sequence

>26038 : length: 1954
MRGPVGTEEELPRLFAEEMENEDEMSEEEDGGLEAFDDFFPVEPVSLPKKKKPKKLKENK
CKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKKKKLKDKKEKKAKRKKKDEDE
DDNDDGCLKEPKSSGQLMAEWGLDDVDYLFSEEDYHTLTNYKAFSQFLRPLIAKKNPKIP
MSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTISPPLAVSPPQVPQPVPIR
KAKTKEGKGPGVRKKIKGSKDGKKKGKGKKTAGLKFRFGGISNKRKKGSSSEEDEREESD
FDSASIHSASVRSECSAALGKKSKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDT
CPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCR
VCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEP
PAPFMVGLPGPDVEPSLPPPKPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYR
NYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMIHRILNH
SFDKKGDVHYLIKWKDLPYDQCTWEIDDIDIPYYDNLKQAYWGHRELMLGEDTRLPKRLL
KKGKKLRDDKQEKPPDTPIVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTD
TILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTY
TGDKESRSVIRENEFSFEDNAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIE
WACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNN
LEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYY
KFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLV
KSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQ
EAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQN
KKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEEL
FKDDVEGMMSQGQRPVTPIPDVQSSKGGNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDA
AISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREIIKQEENVDPDYW
EKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDED
EDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWG
MPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHV
LTRIGVMSLVRKKVQEFEHVNGKYSTPDLIPEGPEGKKSGEVISSDPNTPVPASPAHLLP
APLGLPDKMEAQLGYMDEKDPGAQKPRQPLEVQALPAALDRVESEDKHESPASKERAREE
RPEETEKAPPSPEQLPREEVLPEKEKILDKLELSLIHSRGDSSELRPDDTKAEEKEPIET
QQNGDKEEDDEGKKEDKKGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYDIWHRRH
DYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLARRFKLLEQAL
VIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKV
LNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQGAFGSS
QMYSNNFGPNFRGPGPGGIVNYNQMPLGPYVTDI



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