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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 2719 |
Name | GPC3 |
Synonym | DGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1;glypican 3;GPC3;glypican 3 |
Definition | glypican proteoglycan 3|glypican-3|heparan sulphate proteoglycan|intestinal protein OCI-5|secreted glypican-3 |
Position | Xq26.1 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 2 PubMed records as below. |
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Evidence Status |
Description |
potential | These findings suggest that GPC3 is a candidate lung tumor suppressor gene whose expression may be regulated by exposure to cigarette smoke and functions to modulate cellular response to exogenous damage. |
potential | Candidate lung tumor suppressor gene which may be regulated by tobacco exposure. |
| More detail of all 2 literatures about GPC3 | |
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Pathways and Diseases |
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Pathway | Glypican 3 network;PID Curated;200193 |
Pathway | Glypican pathway;PID Curated;200008 |
Disease | Wilms tumor, somatic;OMIM |
Disease | Simpson-Golabi-Behmel syndrome, type 1;OMIM |
Disease | Cancer;FunDO |
Disease | Ovarian disease;FunDO |
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External Links |
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Links to Entrez Gene | 2719 |
Links to all GeneRIF Items | 2719 |
Links to iHOP | 2719 |
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Sequence Information |
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Nucleotide Sequence |
>2719 : length: 1812 atggccgggaccgtgcgcaccgcgtgcttggtggtggcgatgctgctcagcttggacttc ccgggacaggcgcagcccccgccgccgccgccggacgccacctgtcaccaagtccgctcc ttcttccagagactgcagcccggactcaagtgggtgccagaaactcccgtgccaggatca gatttgcaagtatgtctccctaagggcccaacatgctgctcaagaaagatggaagaaaaa taccaactaacagcacgattgaacatggaacagctgcttcagtctgcaagtatggagctc aagttcttaattattcagaatgctgcggttttccaagaggcctttgaaattgttgttcgc catgccaagaactacaccaatgccatgttcaagaacaactacccaagcctgactccacaa gcttttgagtttgtgggtgaatttttcacagatgtgtctctctacatcttgggttctgac atcaatgtagatgacatggtcaatgaattgtttgacagcctgtttccagtcatctatacc cagctaatgaacccaggcctgcctgattcagccttggacatcaatgagtgcctccgagga gcaagacgtgacctgaaagtatttgggaatttccccaagcttattatgacccaggtttcc aagtcactgcaagtcactaggatcttccttcaggctctgaatcttggaattgaagtgatc aacacaactgatcacctgaagttcagtaaggactgtggccgaatgctcaccagaatgtgg tactgctcttactgccagggactgatgatggttaaaccctgtggcggttactgcaatgtg gtcatgcaaggctgtatggcaggtgtggtggagattgacaagtactggagagaatacatt ctgtcccttgaagaacttgtgaatggcatgtacagaatctatgacatggagaacgtactg cttggtctcttttcaacaatccatgattctatccagtatgtccagaagaatgcaggaaag ctgaccaccactgaaactgagaagaaaatatggcacttcaaatatcctatcttcttcctg tgtatagggctagacttacagattggcaagttatgtgcccattctcaacaacgccaatat agatctgcttattatcctgaagatctctttattgacaagaaagtattaaaagttgctcat gtagaacatgaagaaaccttatccagccgaagaagggaactaattcagaagttgaagtct ttcatcagcttctatagtgctttgcctggctacatctgcagccatagccctgtggcggaa aacgacaccctttgctggaatggacaagaactcgtggagagatacagccaaaaggcagca aggaatggaatgaaaaaccagttcaatctccatgagctgaaaatgaagggccctgagcca gtggtcagtcaaattattgacaaactgaagcacattaaccagctcctgagaaccatgtct atgcccaaaggtagagttctggataaaaacctggatgaggaagggtttgaaagtggagac tgcggtgatgatgaagatgagtgcattggaggctctggtgatggaatgataaaagtgaag aatcagctccgcttccttgcagaactggcctatgatctggatgtggatgatgcgcctgga aacagtcagcaggcaactccgaaggacaacgagataagcacctttcacaacctcgggaac gttcattccccgctgaagcttctcaccagcatggccatctcggtggtgtgcttcttcttc ctggtgcactga |
Protein Sequence |
>2719 : length: 603 MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGS DLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVR HAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYT QLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVI NTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYI LSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTETEKKIWHFKYPIFFL CIGLDLQIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKS FISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEP VVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVK NQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFF LVH |