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| General information | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 29108 |
Name | PYCARD |
Synonym | ASC|CARD5|TMS|TMS-1|TMS1;PYD and CARD domain containing;PYCARD;PYD and CARD domain containing |
Definition | apoptosis-associated speck-like protein containing a CARD|caspase recruitment domain-containing protein 5|target of methylation-induced silencing 1 |
Position | 16p11.2 |
Gene Type | protein-coding |
Source | Count: 2; Generif,UniProt |
Literature support | Count: 2 PubMed records as below. |
Evidence Status | Description |
reviewed | A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. |
reviewed | Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells. |
| More detail of all 2 literatures about PYCARD | |
Pathways and Diseases | |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Cytosolic DNA-sensing pathway;KEGG PATHWAY;hsa04623 |
Disease | Cancer;FunDO |
External Links | |
Links to Entrez Gene | 29108 |
Links to all GeneRIF Items | 29108 |
Links to iHOP | 29108 |
Sequence Information | |
Nucleotide Sequence | >29108 : length: 588 atggggcgcgcgcgcgacgccatcctggatgcgctggagaacctgaccgccgaggagctc aagaagttcaagctgaagctgctgtcggtgccgctgcgcgagggctacgggcgcatcccg cggggcgcgctgctgtccatggacgccttggacctcaccgacaagctggtcagcttctac ctggagacctacggcgccgagctcaccgctaacgtgctgcgcgacatgggcctgcaggag atggccgggcagctgcaggcggccacgcaccagggctctggagccgcgccagctgggatc caggcccctcctcagtcggcagccaagccaggcctgcactttatagaccagcaccgggct gcgcttatcgcgagggtcacaaacgttgagtggctgctggatgctctgtacgggaaggtc ctgacggatgagcagtaccaggcagtgcgggccgagcccaccaacccaagcaagatgcgg aagctcttcagtttcacaccagcctggaactggacctgcaaggacttgctcctccaggcc ctaagggagtcccagtcctacctggtggaggacctggagcggagctga |
Protein Sequence | >29108 : length: 195 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA LRESQSYLVEDLERS |