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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 301 |
Name | ANXA1 |
Synonym | ANX1|LPC1;annexin A1;ANXA1;annexin A1 |
Definition | annexin I (lipocortin I)|annexin-1|calpactin II|calpactin-2|chromobindin-9|lipocortin I|p35|phospholipase A2 inhibitory protein |
Position | 9q12-q21.2|9q21.13 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 3 PubMed records as below. |
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Evidence Status |
Description |
potential | "ANXA1, which was recently reported as a possible tumor suppressor gene, can protect cells from heat-induced growth arrest and DNA damage in breast cancer cells." |
potential | "Annexin I may have tumor suppressor functions in prostate cancer. The pro-apoptotic effect of ANX I involves the activation of p38 and JNK, which appears to shift the balance of signal transduction away from proliferation and toward apoptosis." |
potential | annexin I is not the tumor suppressor gene corresponding to the high levels of loss of heterozygosity observed on chromosome 9 in esophageal squamous cell carcinoma. |
| More detail of all 3 literatures about ANXA1 | |
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Pathways and Diseases |
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Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | corticosteroids and cardioprotection;PID BioCarta;100156 |
Disease | Muscular dystrophies;FunDO |
Disease | diabetes, type 2;GAD |
Disease | Hamman-Rich syndrome;FunDO |
Disease | Hepatitis;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cancer;FunDO |
Disease | METABOLIC;GAD |
Disease | Adrenoleukodystrophy;FunDO |
Disease | Schizophrenia, bipolar disorder and depression (combined);NHGRI |
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External Links |
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Links to Entrez Gene | 301 |
Links to all GeneRIF Items | 301 |
Links to iHOP | 301 |
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Sequence Information |
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Nucleotide Sequence |
>301 : length: 1041 atggcaatggtatcagaattcctcaagcaggcctggtttattgaaaatgaagagcaggaa tatgttcaaactgtgaagtcatccaaaggtggtcccggatcagcggtgagcccctatcct accttcaatccatcctcggatgtcgctgccttgcataaggccataatggttaaaggtgtg gatgaagcaaccatcattgacattctaactaagcgaaacaatgcacagcgtcaacagatc aaagcagcatatctccaggaaacaggaaagcccctggatgaaacacttaagaaagccctt acaggtcaccttgaggaggttgttttagctctgctaaaaactccagcgcaatttgatgct gatgaacttcgtgctgccatgaagggccttggaactgatgaagatactctaattgagatt ttggcatcaagaactaacaaagaaatcagagacattaacagggtctacagagaggaactg aagagagatctggccaaagacataacctcagacacatctggagattttcggaacgctttg ctttctcttgctaagggtgaccgatctgaggactttggtgtgaatgaagacttggctgat tcagatgccagggccttgtatgaagcaggagaaaggagaaaggggacagacgtaaacgtg ttcaataccatccttaccaccagaagctatccacaacttcgcagagtgtttcagaaatac accaagtacagtaagcatgacatgaacaaagttctggacctggagttgaaaggtgacatt gagaaatgcctcacagctatcgtgaagtgcgccacaagcaaaccagctttctttgcagag aagcttcatcaagccatgaaaggtgttggaactcgccataaggcattgatcaggattatg gtttcccgttctgaaattgacatgaatgatatcaaagcattctatcagaagatgtatggt atctccctttgccaagccatcctggatgaaaccaaaggagattatgagaaaatcctggtg gctctttgtggaggaaactaa |
Protein Sequence |
>301 : length: 346 MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN |