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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3417 |
Name | IDH1 |
Synonym | IDCD|IDH|IDP|IDPC|PICD;isocitrate dehydrogenase 1 (NADP+), soluble;IDH1;isocitrate dehydrogenase 1 (NADP+), soluble |
Definition | NADP(+)-specific ICDH|NADP-dependent isocitrate dehydrogenase, cytosolic|NADP-dependent isocitrate dehydrogenase, peroxisomal|isocitrate dehydrogenase [NADP] cytoplasmic|oxalosuccinate decarboxylase |
Position | 2q33.3 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | "IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway". |
| More detail of all 1 literatures about IDH1 | |
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Pathways and Diseases |
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Pathway | Citrate cycle (TCA cycle);KEGG PATHWAY;hsa00020 |
Pathway | respiration (anaerobic);BioCyc;ANARESP1-PWY |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Glutathione metabolism;KEGG PATHWAY;hsa00480 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | Peroxisome;KEGG PATHWAY;hsa04146 |
Pathway | NADPH regeneration;PID Reactome;500823 |
Disease | Cancer;FunDO |
Disease | Neoplasm metastasis;FunDO |
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External Links |
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Links to Entrez Gene | 3417 |
Links to all GeneRIF Items | 3417 |
Links to iHOP | 3417 |
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Sequence Information |
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Nucleotide Sequence |
>3417 : length: 1245 atgtccaaaaaaatcagtggcggttctgtggtagagatgcaaggagatgaaatgacacga atcatttgggaattgattaaagagaaactcatttttccctacgtggaattggatctacat agctatgatttaggcatagagaatcgtgatgccaccaacgaccaagtcaccaaggatgct gcagaagctataaagaagcataatgttggcgtcaaatgtgccactatcactcctgatgag aagagggttgaggagttcaagttgaaacaaatgtggaaatcaccaaatggcaccatacga aatattctgggtggcacggtcttcagagaagccattatctgcaaaaatatcccccggctt gtgagtggatgggtaaaacctatcatcataggtcgtcatgcttatggggatcaatacaga gcaactgattttgttgttcctgggcctggaaaagtagagataacctacacaccaagtgac ggaacccaaaaggtgacatacctggtacataactttgaagaaggtggtggtgttgccatg gggatgtataatcaagataagtcaattgaagattttgcacacagttccttccaaatggct ctgtctaagggttggcctttgtatctgagcaccaaaaacactattctgaagaaatatgat gggcgttttaaagacatctttcaggagatatatgacaagcagtacaagtcccagtttgaa gctcaaaagatctggtatgagcataggctcatcgacgacatggtggcccaagctatgaaa tcagagggaggcttcatctgggcctgtaaaaactatgatggtgacgtgcagtcggactct gtggcccaagggtatggctctctcggcatgatgaccagcgtgctggtttgtccagatggc aagacagtagaagcagaggctgcccacgggactgtaacccgtcactaccgcatgtaccag aaaggacaggagacgtccaccaatcccattgcttccatttttgcctggaccagagggtta gcccacagagcaaagcttgataacaataaagagcttgccttctttgcaaatgctttggaa gaagtctctattgagacaattgaggctggcttcatgaccaaggacttggctgcttgcatt aaaggtttacccaatgtgcaacgttctgactacttgaatacatttgagttcatggataaa cttggagaaaacttgaagatcaaactagctcaggccaaactttaa |
Protein Sequence |
>3417 : length: 414 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL |