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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3482 |
Name | IGF2R |
Synonym | CD222|CIMPR|M6P-R|MPR1|MPRI;insulin-like growth factor 2 receptor;IGF2R;insulin-like growth factor 2 receptor |
Definition | 300 kDa mannose 6-phosphate receptor|CI Man-6-P receptor|CI-MPR|IGF-II receptor|M6P/IGF2 receptor|M6P/IGF2R|M6PR|MPR 300|cation-independent mannose-6 phosphate receptor|cation-independent mannose-6-phosphate receptor|insulin-like growth factor II receptor |
Position | 6q26 |
Gene Type | protein-coding |
Source | Count: 2; TAG,Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | M6P/IGF2 receptor: a candidate breast tumor suppressor gene. |
| More detail of all 1 literatures about IGF2R | |
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Pathways and Diseases |
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Pathway | Membrane Trafficking;Reactome;REACT:11123 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | Lysosome;KEGG PATHWAY;hsa04142 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Disease | oral cancer;GAD |
Disease | REPRODUCTION;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | IMMUNE;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Brain lesion load;GAD |
Disease | birth weight fetal growth;GAD |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Hepatocellular carcinoma;OMIM |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Alzheimer's disease;FunDO |
Disease | Brain lesion load;NHGRI |
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External Links |
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Links to Entrez Gene | 3482 |
Links to all GeneRIF Items | 3482 |
Links to iHOP | 3482 |
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Sequence Information |
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Nucleotide Sequence |
>3482 : length: 7476 atgggggccgccgccggccggagcccccacctggggcccgcgcccgcccgccgcccgcag cgctctctgctcctgctgcagctgctgctgctcgtcgctgccccggggtccacgcaggcc caggccgccccgttccccgagctgtgcagttatacatgggaagctgttgataccaaaaat aatgtactttataaaatcaacatctgtggaagtgtggatattgtccagtgcgggccatca agtgctgtttgtatgcacgacttgaagacacgcacttatcattcagtgggtgactctgtt ttgagaagtgcaaccagatctctcctggaattcaacacaacagtgagctgtgaccagcaa ggcacaaatcacagagtccagagcagcattgccttcctgtgtgggaaaaccctgggaact cctgaatttgtaactgcaacagaatgtgtgcactactttgagtggaggaccactgcagcc tgcaagaaagacatatttaaagcaaataaggaggtgccatgctatgtgtttgatgaagag ttgaggaagcatgatctcaatcctctgatcaagcttagtggtgcctacttggtggatgac tccgatccggacacttctctattcatcaatgtttgtagagacatagacacactacgagac ccaggttcacagctgcgggcctgtccccccggcactgccgcctgcctggtaagaggacac caggcgtttgatgttggccagccccgggacggactgaagctggtgcgcaaggacaggctt gtcctgagttacgtgagggaagaggcaggaaagctagacttttgtgatggtcacagccct gcggtgactattacatttgtttgcccgtcggagcggagagagggcaccattcccaaactc acagctaaatccaactgccgctatgaaattgagtggattactgagtatgcctgccacaga gattacctggaaagtaaaacttgttctctgagcggcgagcagcaggatgtctccatagac ctcacaccacttgcccagagcggaggttcatcctatatttcagatggaaaagaatatttg ttttatttgaatgtctgtggagaaactgaaatacagttctgtaataaaaaacaagctgca gtttgccaagtgaaaaagagcgatacctctcaagtcaaagcagcaggaagataccacaat cagaccctccgatattcggatggagacctcaccttgatatattttggaggtgatgaatgc agctcagggtttcagcggatgagcgtcataaactttgagtgcaataaaaccgcaggtaac gatgggaaaggaactcctgtattcacaggggaggttgactgcacctacttcttcacatgg gacacggaatacgcctgtgttaaggagaaggaagacctcctctgcggtgccaccgacggg aagaagcgctatgacctgtccgcgctggtccgccatgcagaaccagagcagaattgggaa gctgtggatggcagtcagacggaaacagagaagaagcattttttcattaatatttgtcac agagtgctgcaggaaggcaaggcacgagggtgtcccgaggacgcggcagtgtgtgcagtg gataaaaatggaagtaaaaatctgggaaaatttatttcctctcccatgaaagagaaagga aacattcaactctcttattcagatggtgatgattgtggtcatggcaagaaaattaaaact aatatcacacttgtatgcaagccaggtgatctggaaagtgcaccagtgttgagaacttct ggggaaggcggttgcttttatgagtttgagtggcacacagctgcggcctgtgtgctgtct aagacagaaggggagaactgcacggtctttgactcccaggcagggttttcttttgactta tcacctctcacaaagaaaaatggtgcctataaagttgagacaaagaagtatgacttttat ataaatgtgtgtggcccggtgtctgtgagcccctgtcagccagactcaggagcctgccag gtggcaaaaagtgatgagaagacttggaacttgggtctgagtaatgcgaagctttcatat tatgatgggatgatccaactgaactacagaggcggcacaccctataacaatgaaagacac acaccgagagctacgctcatcacctttctctgtgatcgagacgcgggagtgggcttccct gaatatcaggaagaggataactccacctacaacttccggtggtacaccagctatgcctgc ccggaggagcccctggaatgcgtagtgaccgacccctccacgctggagcagtacgacctc tccagtctggcaaaatctgaaggtggccttggaggaaactggtatgccatggacaactca ggggaacatgtcacgtggaggaaatactacattaacgtgtgtcggcctctgaatccagtg ccgggctgcaaccgatatgcatcggcttgccagatgaagtatgaaaaagatcagggctcc ttcactgaagtggtttccatcagtaacttgggaatggcaaagaccggcccggtggttgag gacagcggcagcctccttctggaatacgtgaatgggtcggcctgcaccaccagcgatggc agacagaccacatataccacgaggatccatctcgtctgctccaggggcaggctgaacagc caccccatcttttctctcaactgggagtgtgtggtcagtttcctgtggaacacagaggct gcctgtcccattcagacaacgacggatacagaccaggcttgctctataagggatcccaac agtggatttgtgtttaatcttaatccgctaaacagttcgcaaggatataacgtctctggc attgggaagatttttatgtttaatgtctgcggcacaatgcctgtctgtgggaccatcctg ggaaaacctgcttctggctgtgaggcagaaacccaaactgaagagctcaagaattggaag ccagcaaggccagtcggaattgagaaaagcctccagctgtccacagagggcttcatcact ctgacctacaaagggcctctctctgccaaaggtaccgctgatgcttttatcgtccgcttt gtttgcaatgatgatgtttactcagggcccctcaaattcctgcatcaagatatcgactct gggcaagggatccgaaacacttactttgagtttgaaaccgcgttggcctgtgttccttct ccagtggactgccaagtcaccgacctggctggaaatgagtacgacctgactggcctaagc acagtcaggaaaccttggacggctgttgacacctctgtcgatgggagaaagaggactttc tatttgagcgtttgcaatcctctcccttacattcctggatgccagggcagcgcagtgggg tcttgcttagtgtcagaaggcaatagctggaatctgggtgtggtgcagatgagtccccaa gccgcggcgaatggatctttgagcatcatgtatgtcaacggtgacaagtgtgggaaccag cgcttctccaccaggatcacgtttgagtgtgctcagatatcgggctcaccagcatttcag cttcaggatggttgtgagtacgtgtttatctggagaactgtggaagcctgtcccgttgtc agagtggaaggggacaactgtgaggtgaaagacccaaggcatggcaacttgtatgacctg aagcccctgggcctcaacgacaccatcgtgagcgctggcgaatacacttattacttccgg gtctgtgggaagctttcctcagacgtctgccccacaagtgacaagtccaaggtggtctcc tcatgtcaggaaaagcgggaaccgcagggatttcacaaagtggcaggtctcctgactcag aagctaacttatgaaaatggcttgttaaaaatgaacttcacggggggggacacttgccat aaggtttatcagcgctccacagccatcttcttctactgtgaccgcggcacccagcggcca gtatttctaaaggagacttcagattgttcctacttgtttgagtggcgaacgcagtatgcc tgcccacctttcgatctgactgaatgttcattcaaagatggggctggcaactccttcgac ctctcgtccctgtcaaggtacagtgacaactgggaagccatcactgggacgggggacccg gagcactacctcatcaatgtctgcaagtctctggccccgcaggctggcactgagccgtgc cctccagaagcagccgcgtgtctgctgggtggctccaagcccgtgaacctcggcagggta agggacggacctcagtggagagatggcataattgtcctgaaatacgttgatggcgactta tgtccagatgggattcggaaaaagtcaaccaccatccgattcacctgcagcgagagccaa gtgaactccaggcccatgttcatcagcgccgtggaggactgtgagtacacctttgcctgg cccacagccacagcctgtcccatgaagagcaacgagcatgatgactgccaggtcaccaac ccaagcacaggacacctgtttgatctgagctccttaagtggcagggcgggattcacagct gcttacagcgagaaggggttggtttacatgagcatctgtggggagaatgaaaactgccct cctggcgtgggggcctgctttggacagaccaggattagcgtgggcaaggccaacaagagg ctgagatacgtggaccaggtcctgcagctggtgtacaaggatgggtccccttgtccctcc aaatccggcctgagctataagagtgtgatcagtttcgtgtgcaggcctgaggccgggcca accaataggcccatgctcatctccctggacaagcagacatgcactctcttcttctcctgg cacacgccgctggcctgcgagcaagcgaccgaatgttccgtgaggaatggaagctctatt gttgacttgtctccccttattcatcgcactggtggttatgaggcttatgatgagagtgag gatgatgcctccgataccaaccctgatttctacatcaatatttgtcagccactaaatccc atgcacggagtgccctgtcctgccggagccgctgtgtgcaaagttcctattgatggtccc cccatagatatcggccgggtagcaggaccaccaatactcaatccaatagcaaatgagatt tacttgaattttgaaagcagtactccttgcttagcggacaagcatttcaactacacctcg ctcatcgcgtttcactgtaagagaggtgtgagcatgggaacgcctaagctgttaaggacc agcgagtgcgactttgtgttcgaatgggagactcctgtcgtctgtcctgatgaagtgagg atggatggctgtaccctgacagatgagcagctcctctacagcttcaacttgtccagcctt tccacgagcacctttaaggtgactcgcgactcgcgcacctacagcgttggggtgtgcacc tttgcagtcgggccagaacaaggaggctgtaaggacggaggagtctgtctgctctcaggc accaagggggcatcctttggacggctgcaatcaatgaaactggattacaggcaccaggat gaagcggtcgttttaagttacgtgaatggtgatcgttgccctccagaaaccgatgacggc gtcccctgtgtcttccccttcatattcaatgggaagagctacgaggagtgcatcatagag agcagggcgaagctgtggtgtagcacaactgcggactacgacagagaccacgagtggggc ttctgcagacactcaaacagctaccggacatccagcatcatatttaagtgtgatgaagat gaggacattgggaggccacaagtcttcagtgaagtgcgtgggtgtgatgtgacatttgag tggaaaacaaaagttgtctgccctccaaagaagttggagtgcaaattcgtccagaaacac aaaacctacgacctgcggctgctctcctctctcaccgggtcctggtccctggtccacaac ggagtctcgtactatataaatctgtgccagaaaatatataaagggcccctgggctgctct gaaagggccagcatttgcagaaggaccacaactggtgacgtccaggtcctgggactcgtt cacacgcagaagctgggtgtcataggtgacaaagttgttgtcacgtactccaaaggttat ccgtgtggtggaaataagaccgcatcctccgtgatagaattgacctgtacaaagacggtg ggcagacctgcattcaagaggtttgatatcgacagctgcacttactacttcagctgggac tcccgggctgcctgcgccgtgaagcctcaggaggtgcagatggtgaatgggaccatcacc aaccctataaatggcaagagcttcagcctcggagatatttattttaagctgttcagagcc tctggggacatgaggaccaatggggacaactacctgtatgagatccaactttcctccatc acaagctccagaaacccggcgtgctctggagccaacatatgccaggtgaagcccaacgat cagcacttcagtcggaaagttggaacctctgacaagaccaagtactaccttcaagacggc gatctcgatgtcgtgtttgcctcttcctctaagtgcggaaaggataagaccaagtctgtt tcttccaccatcttcttccactgtgaccctctggtggaggacgggatccccgagttcagt cacgagactgccgactgccagtacctcttctcttggtacacctcagccgtgtgtcctctg ggggtgggctttgacagcgagaatcccggggacgacgggcagatgcacaaggggctgtca gaacggagccaggcagtcggcgcggtgctcagcctgctgctggtggcgctcacctgctgc ctgctggccctgttgctctacaagaaggagaggagggaaacagtgataagtaagctgacc acttgctgtaggagaagttccaacgtgtcctacaaatactcaaaggtgaataaggaagaa gagacagatgagaatgaaacagagtggctgatggaagagatccagctgcctcctccacgg cagggaaaggaagggcaggagaacggccatattaccaccaagtcagtgaaagccctcagc tccctgcatggggatgaccaggacagtgaggatgaggttctgaccatcccagaggtgaaa gttcactcgggcaggggagctggggcagagagctcccacccagtgagaaacgcacagagc aatgcccttcaggagcgtgaggacgatagggtggggctggtcaggggtgagaaggcgagg aaagggaagtccagctctgcacagcagaagacagtgagctccaccaagctggtgtccttc catgacgacagcgacgaggacctcttacacatctga |
Protein Sequence |
>3482 : length: 2491 MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKN NVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQ GTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEE LRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGH QAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKL TAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYL FYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDEC SSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDG KKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAV DKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTS GEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFY INVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERH TPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDL SSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGS FTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNS HPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSG IGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFIT LTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPS PVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVG SCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQ LQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFR VCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCH KVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFD LSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRV RDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAW PTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCP PGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGP TNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESE DDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEI YLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVR MDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSG TKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIE SRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFE WKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCS ERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTV GRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRA SGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDG DLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPL GVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLT TCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALS SLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKAR KGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI |