Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

3651

Name

PDX1

Synonym

GSF|IDX-1|IPF1|IUF1|MODY4|PDX-1|STF-1;pancreatic and duodenal homeobox 1;PDX1;pancreatic and duodenal homeobox 1

Definition

IPF-1|IUF-1|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|islet/duodenum homeobox-1|pancreas/duodenum homeobox protein 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription fact

Position

13q12.1

Gene Type

protein-coding

Source

Count: 1; Generif

Literature support

Count: 1 PubMed records as below.

Evidence Status

Description

potential

"PDX1 expression is lost in gastric cancers. Its effect on cell proliferation/apoptosis, migration and tumor formation in vitro and in vivo suggested that this protein functions as a putative tumor suppressor in gastric cancer."
More detail of all 1 literatures about PDX1

Pathways and Diseases

Pathway

Regulation of beta-cell development;PID Reactome;500518

Pathway

Maturity onset diabetes of the young;KEGG PATHWAY;hsa04950

Pathway

Insulin Synthesis and Processing;PID Reactome;500128

Pathway

FOXA2 and FOXA3 transcription factor networks;PID Curated;200073

Pathway

Type II diabetes mellitus;KEGG PATHWAY;hsa04930

Pathway

Regulation of gene expression in beta cells;PID Reactome;500522

Pathway

Regulation of beta-cell development;Reactome;REACT:13698

Pathway

Regulation of gene expression in early pancreatic precursor cells;PID Reactome;500519

Disease

Maturity onset diabetes of the young (MODY);KEGG DISEASE;H00410

Disease

Alimentary system disease;FunDO

Disease

Lacticacidemia due to PDX1 deficiency;OMIM

Disease

diabetes, type 2;GAD

Disease

Metabolic diseases;KEGG DISEASE

Disease

Diabetes mellitus, type II, susceptibility to;OMIM

Disease

Prostate cancer;FunDO

Disease

Enteritis;FunDO

Disease

Attention deficit hyperactivity disorder and conduct disorder;GAD

Disease

MODY, type IV;OMIM

Disease

Pancreas disease;FunDO

Disease

PSYCH;GAD

Disease

Diabetes;KEGG DISEASE

Disease

Pancreatic agenesis;OMIM

Disease

Neoplasm metastasis;FunDO

Disease

METABOLIC;GAD

External Links

Links to Entrez Gene

3651

Links to all GeneRIF Items

3651

Links to iHOP

3651

Sequence Information

Nucleotide Sequence

>3651 : length: 852
atgaacggcgaggagcagtactacgcggccacgcagctttacaaggacccatgcgcgttc
cagcgaggcccggcgccggagttcagcgccagcccccctgcgtgcctgtacatgggccgc
cagcccccgccgccgccgccgcacccgttccctggcgccctgggcgcgctggagcagggc
agccccccggacatctccccgtacgaggtgccccccctcgccgacgaccccgcggtggcg
caccttcaccaccacctcccggctcagctcgcgctcccccacccgcccgccgggcccttc
ccggagggagccgagccgggcgtcctggaggagcccaaccgcgtccagctgcctttccca
tggatgaagtctaccaaagctcacgcgtggaaaggccagtgggcaggcggcgcctacgct
gcggagccggaggagaacaagcggacgcgcacggcctacacgcgcgcacagctgctagag
ctggagaaggagttcctattcaacaagtacatctcacggccgcgccgggtggagctggct
gtcatgttgaacttgaccgagagacacatcaagatctggttccaaaaccgccgcatgaag
tggaaaaaggaggaggacaagaagcgcggcggcgggacagctgtcgggggtggcggggtc
gcggagcctgagcaggactgcgccgtgacctccggcgaggagcttctggcgctgccgccg
ccgccgccccccggaggtgctgtgccgcccgctgcccccgttgccgcccgagagggccgc
ctgccgcctggccttagcgcgtcgccacagccctccagcgtcgcgcctcggcggccgcag
gaaccacgatga

Protein Sequence

>3651 : length: 283
MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQG
SPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFP
WMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELA
VMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPP
PPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR



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