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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3688 |
Name | ITGB1 |
Synonym | CD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLAB;integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12);ITGB1;integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
Definition | integrin VLA-4 beta subunit|integrin beta-1|very late activation protein, beta polypeptide |
Position | 10p11.2 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling. |
| More detail of all 1 literatures about ITGB1 | |
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Pathways and Diseases |
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Pathway | agrin in postsynaptic differentiation;PID BioCarta;100252 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Signaling events mediated by PRL;PID Curated;200006 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Collagen adhesion via alpha 2 beta 1 glycoprotein;PID Reactome;501010 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | ucalpain and friends in cell spread;PID BioCarta;100008 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Pathway | Other semaphorin interactions;PID Reactome;500078 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | a4b1 and a4b7 Integrin signaling;PID Curated;200092 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Localization of the PINCH-ILK-PARVIN complex to focal adhesions;PID Reactome;500124 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | Dilated cardiomyopathy;KEGG PATHWAY;hsa05414 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Disease | Drug abuse;FunDO |
Disease | Lupus erythematosus;FunDO |
Disease | Pleural effusion, Malignant;FunDO |
Disease | Shigella infection;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | Alopecia;FunDO |
Disease | Primary hyperparathyroidism;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Thalassemia;FunDO |
Disease | Pemphigoid, Bullous;FunDO |
Disease | Cancer;FunDO |
Disease | Purpura, Thrombocytopenic, Idiopathic;FunDO |
Disease | Systemic infection;FunDO |
Disease | Sickle cell disease;FunDO |
Disease | Depression;FunDO |
Disease | Depression--quantitative trait;NHGRI |
Disease | Aortic aneurysm;FunDO |
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External Links |
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Links to Entrez Gene | 3688 |
Links to all GeneRIF Items | 3688 |
Links to iHOP | 3688 |
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Sequence Information |
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Nucleotide Sequence |
>3688 : length: 2397 atgaatttacaaccaattttctggattggactgatcagttcagtttgctgtgtgtttgct caaacagatgaaaatagatgtttaaaagcaaatgccaaatcatgtggagaatgtatacaa gcagggccaaattgtgggtggtgcacaaattcaacatttttacaggaaggaatgcctact tctgcacgatgtgatgatttagaagccttaaaaaagaagggttgccctccagatgacata gaaaatcccagaggctccaaagatataaagaaaaataaaaatgtaaccaaccgtagcaaa ggaacagcagagaagctcaagccagaggatattactcagatccaaccacagcagttggtt ttgcgattaagatcaggggagccacagacatttacattaaaattcaagagagctgaagac tatcccattgacctctactaccttatggacctgtcttactcaatgaaagacgatttggag aatgtaaaaagtcttggaacagatctgatgaatgaaatgaggaggattacttcggacttc agaattggatttggctcatttgtggaaaagactgtgatgccttacattagcacaacacca gctaagctcaggaacccttgcacaagtgaacagaactgcaccagcccatttagctacaaa aatgtgctcagtcttactaataaaggagaagtatttaatgaacttgttggaaaacagcgc atatctggaaatttggattctccagaaggtggtttcgatgccatcatgcaagttgcagtt tgtggatcactgattggctggaggaatgttacacggctgctggtgttttccacagatgcc gggtttcactttgctggagatgggaaacttggtggcattgttttaccaaatgatggacaa tgtcacctggaaaataatatgtacacaatgagccattattatgattatccttctattgct caccttgtccagaaactgagtgaaaataatattcagacaatttttgcagttactgaagaa tttcagcctgtttacaaggagctgaaaaacttgatccctaagtcagcagtaggaacatta tctgcaaattctagcaatgtaattcagttgatcattgatgcatacaattccctttcctca gaagtcattttggaaaacggcaaattgtcagaaggcgtaacaataagttacaaatcttac tgcaagaacggggtgaatggaacaggggaaaatggaagaaaatgttccaatatttccatt ggagatgaggttcaatttgaaattagcataacttcaaataagtgtccaaaaaaggattct gacagctttaaaattaggcctctgggctttacggaggaagtagaggttattcttcagtac atctgtgaatgtgaatgccaaagcgaaggcatccctgaaagtcccaagtgtcatgaagga aatgggacatttgagtgtggcgcgtgcaggtgcaatgaagggcgtgttggtagacattgt gaatgcagcacagatgaagttaacagtgaagacatggatgcttactgcaggaaagaaaac agttcagaaatctgcagtaacaatggagagtgcgtctgcggacagtgtgtttgtaggaag agggataatacaaatgaaatttattctggcaaattctgcgagtgtgataatttcaactgt gatagatccaatggcttaatttgtggaggaaatggtgtttgcaagtgtcgtgtgtgtgag tgcaaccccaactacactggcagtgcatgtgactgttctttggatactagtacttgtgaa gccagcaacggacagatctgcaatggccggggcatctgcgagtgtggtgtctgtaagtgt acagatccgaagtttcaagggcaaacgtgtgagatgtgtcagacctgccttggtgtctgt gctgagcataaagaatgtgttcagtgcagagccttcaataaaggagaaaagaaagacaca tgcacacaggaatgttcctattttaacattaccaaggtagaaagtcgggacaaattaccc cagccggtccaacctgatcctgtgtcccattgtaaggagaaggatgttgacgactgttgg ttctattttacgtattcagtgaatgggaacaacgaggtcatggttcatgttgtggagaat ccagagtgtcccactggtccagacatcattccaattgtagctggtgtggttgctggaatt gttcttattggccttgcattactgctgatatggaagcttttaatgataattcatgacaga agggagtttgctaaatttgaaaaggagaaaatgaatgccaaatgggacacgggtgaaaat cctatttataagagtgccgtaacaactgtggtcaatccgaagtatgagggaaaatga |
Protein Sequence |
>3688 : length: 798 MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLV LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQR ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN PIYKSAVTTVVNPKYEGK |