Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

4163

Name

MCC

Synonym

MCC1;mutated in colorectal cancers;MCC;mutated in colorectal cancers

Definition

colorectal mutant cancer protein

Position

5q21

Gene Type

protein-coding

Source

Count: 4; Pubmed_search,TAG,Generif,UniProt

Literature support

Count: 2 PubMed records as below.

Evidence Status

Description

potential

"MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction."

potential

"Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis."
More detail of all 2 literatures about MCC

External Links

Links to Entrez Gene

4163

Links to all GeneRIF Items

4163

Links to iHOP

4163

Sequence Information

Nucleotide Sequence

>4163 : length: 3060
atgatggcggccgcggcggcagcggctgcggggagctccagcagcggcggcggcggcggc
ggcagcggcagcagcagcagcagcagcgacacgtccagcaccggcgaggaggagaggatg
cggcgcctcttccagacgtgcgacggcgacggggacggatacatcagcagaaatgacttg
ctaatggtctgtcgccagctgaatatggaagagtctgtggctgagatcatgaaccagttg
ggagcagatgaaaatgggaagatttcctttcaggatttcacaagatgccgcatgcagctt
gttcgagaaattaggaaggaggaagtagatctttctgcaaagtcagacaactcctgtaca
aagaagctgagggatagaattgcttcctggcccacgagcagtgacaacagtttgggtgcc
ttatcagcagccagggagagctgggaatacgactctggtgccagggacctccagagcccg
gatgtgcagagccagtcagccctccagaagctgctcgagtatggcggaagctctttgcat
cagcaggctgctctccacaaactgctcacacagtccccgcacattggcaactctgtagga
ggaagctatctagagctggccaacacactccattcagcagccctggcatcactaaaggga
gatatagtggaacttaataaacgtctccagcaaacagagagggaacgggaccttctggaa
aagaaattggccaaggcacagtgcgagcagtcccacctcatgagagagcatgaggatgtc
caggagcgaacgacacttcgctatgaggaacgcatcacagagctccacagcgtcattgcg
gagctcaacaagaagatagaccgtctgcaaggcaccaccatcagggaggaagatgagtac
tcagaactgcgatcagaactcagccagagccaacacgaggtcaacgaggactctcgaagc
atggaccaagaccagacctctgtctctatccccgaaaaccagtctaccatggttactgct
gacatggacaactgcagtgacctgaactcagaactgcagagggtgctgacagggctggag
aatgttgtctgcggcaggaagaagagcagctgcagcctctccgtggccgaggtggacagg
cacattgagcagctcaccacagccagcgagcactgtgacctggctattaagacagtcgag
gagattgagggggtgcttggccgggacctgtatcccaacctggctgaagagaggtctcgg
tgggagaaggagctggctgggctgagggaagagaatgagagcctgactgccatgctgtgc
agcaaagaggaagaactgaaccggactaaggccaccatgaatgccatccgggaagagcgg
gaccggctccggaggagggtcagagagcttcaaactcgactacagagcgtgcaggccaca
ggtccctccagccctggccgcctcacttccaccaaccgcccgattaaccccagcactggg
gagctgagcacaagcagcagcagcaatgacattcccatcgccaagattgctgagagggtg
aagctatcaaagacaaggtccgaatcgtcatcatctgatcggccagtcctgggctcagaa
atcagtagcataggggtatccagcagtgtggctgaacacctggcccactcacttcaggac
tgctccaatatccaagagattttccaaacactctactcacacggatctgccatctcagaa
agcaagattagagagtttgaggtggaaacagaacggctgaatagccggattgagcacctc
aaatcccaaaatgacctcctgaccataaccttggaggaatgtaaaagcaatgccgagagg
atgagcatgctggtgggaaaatacgaatccaatgccacagcgctgaggctggccttgcag
tacagcgagcagtgcatcgaagcctacgaactcctcctggcgctggcagagagtgagcag
agcctcatcctggggcagttccgagcggcgggcgtggggtcctcccctggagaccagtcg
ggggatgaaaacatcactcagatgctcaagcgagctcatgactgccggaagacagctgag
aacgctgccaaggccctgctcatgaagctggacggcagctgtgggggagcctttgccgtg
gccggctgcagcgtgcagccctgggagagcctttcctccaacagccacaccagcacaacc
agctccacagccagtagttgcgacaccgagttcactaaagaagacgagcagaggctgaag
gattatatccagcagctcaagaatgacagggctgcggtcaagctgaccatgctggagctg
gaaagcatccacatcgatcctctcagctatgacgtcaagcctcggggagacagccagagg
ctggatctggaaaacgcagtgcttatgcaggagctcatggccatgaaggaggagatggcc
gagttgaaggcccagctctacctactggagaaagagaagaaggccctggagctgaagctg
agcacgcgggaggcccaggagcaggcctacctggtgcacattgagcacctgaagtccgag
gtggaggagcagaaggagcagcggatgcgatccctcagctccaccagcagcggcagcaaa
gacaaacctggcaaggagtgtgctgatgctgcctccccagctctgtccctagccgaactc
aggacaacgtgcagcgagaatgagctggctgcggagttcaccaacgccattcgtcgagaa
aagaagttgaaggccagagttcaagagctggtgagtgccttggagagactcaccaagagc
agtgaaatccgacatcagcaatctgcagagttcgtgaatgatctaaagcgggccaacagc
aacctggtggctgcctatgagaaagcaaagaaaaagcatcaaaacaaactgaagaagtta
gagtcgcagatgatggccatggtggagagacatgagacccaagtgaggatgctcaagcaa
agaatagctctgctagaggaggagaactccaggccacacaccaatgaaacttcgctttaa

Protein Sequence

>4163 : length: 1019
MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDL
LMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT
KKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLH
QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE
KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY
SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE
NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR
WEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQAT
GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE
ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL
KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ
SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV
AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLEL
ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL
STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL
RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS
NLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL



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