|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4163 |
Name | MCC |
Synonym | MCC1;mutated in colorectal cancers;MCC;mutated in colorectal cancers |
Definition | colorectal mutant cancer protein |
Position | 5q21 |
Gene Type | protein-coding |
Source | Count: 4; Pubmed_search,TAG,Generif,UniProt |
Literature support | Count: 2 PubMed records as below. |
|
Evidence Status |
Description |
potential | "MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction." |
potential | "Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis." |
| More detail of all 2 literatures about MCC | |
|
External Links |
|
Links to Entrez Gene | 4163 |
Links to all GeneRIF Items | 4163 |
Links to iHOP | 4163 |
|
Sequence Information |
|
Nucleotide Sequence |
>4163 : length: 3060 atgatggcggccgcggcggcagcggctgcggggagctccagcagcggcggcggcggcggc ggcagcggcagcagcagcagcagcagcgacacgtccagcaccggcgaggaggagaggatg cggcgcctcttccagacgtgcgacggcgacggggacggatacatcagcagaaatgacttg ctaatggtctgtcgccagctgaatatggaagagtctgtggctgagatcatgaaccagttg ggagcagatgaaaatgggaagatttcctttcaggatttcacaagatgccgcatgcagctt gttcgagaaattaggaaggaggaagtagatctttctgcaaagtcagacaactcctgtaca aagaagctgagggatagaattgcttcctggcccacgagcagtgacaacagtttgggtgcc ttatcagcagccagggagagctgggaatacgactctggtgccagggacctccagagcccg gatgtgcagagccagtcagccctccagaagctgctcgagtatggcggaagctctttgcat cagcaggctgctctccacaaactgctcacacagtccccgcacattggcaactctgtagga ggaagctatctagagctggccaacacactccattcagcagccctggcatcactaaaggga gatatagtggaacttaataaacgtctccagcaaacagagagggaacgggaccttctggaa aagaaattggccaaggcacagtgcgagcagtcccacctcatgagagagcatgaggatgtc caggagcgaacgacacttcgctatgaggaacgcatcacagagctccacagcgtcattgcg gagctcaacaagaagatagaccgtctgcaaggcaccaccatcagggaggaagatgagtac tcagaactgcgatcagaactcagccagagccaacacgaggtcaacgaggactctcgaagc atggaccaagaccagacctctgtctctatccccgaaaaccagtctaccatggttactgct gacatggacaactgcagtgacctgaactcagaactgcagagggtgctgacagggctggag aatgttgtctgcggcaggaagaagagcagctgcagcctctccgtggccgaggtggacagg cacattgagcagctcaccacagccagcgagcactgtgacctggctattaagacagtcgag gagattgagggggtgcttggccgggacctgtatcccaacctggctgaagagaggtctcgg tgggagaaggagctggctgggctgagggaagagaatgagagcctgactgccatgctgtgc agcaaagaggaagaactgaaccggactaaggccaccatgaatgccatccgggaagagcgg gaccggctccggaggagggtcagagagcttcaaactcgactacagagcgtgcaggccaca ggtccctccagccctggccgcctcacttccaccaaccgcccgattaaccccagcactggg gagctgagcacaagcagcagcagcaatgacattcccatcgccaagattgctgagagggtg aagctatcaaagacaaggtccgaatcgtcatcatctgatcggccagtcctgggctcagaa atcagtagcataggggtatccagcagtgtggctgaacacctggcccactcacttcaggac tgctccaatatccaagagattttccaaacactctactcacacggatctgccatctcagaa agcaagattagagagtttgaggtggaaacagaacggctgaatagccggattgagcacctc aaatcccaaaatgacctcctgaccataaccttggaggaatgtaaaagcaatgccgagagg atgagcatgctggtgggaaaatacgaatccaatgccacagcgctgaggctggccttgcag tacagcgagcagtgcatcgaagcctacgaactcctcctggcgctggcagagagtgagcag agcctcatcctggggcagttccgagcggcgggcgtggggtcctcccctggagaccagtcg ggggatgaaaacatcactcagatgctcaagcgagctcatgactgccggaagacagctgag aacgctgccaaggccctgctcatgaagctggacggcagctgtgggggagcctttgccgtg gccggctgcagcgtgcagccctgggagagcctttcctccaacagccacaccagcacaacc agctccacagccagtagttgcgacaccgagttcactaaagaagacgagcagaggctgaag gattatatccagcagctcaagaatgacagggctgcggtcaagctgaccatgctggagctg gaaagcatccacatcgatcctctcagctatgacgtcaagcctcggggagacagccagagg ctggatctggaaaacgcagtgcttatgcaggagctcatggccatgaaggaggagatggcc gagttgaaggcccagctctacctactggagaaagagaagaaggccctggagctgaagctg agcacgcgggaggcccaggagcaggcctacctggtgcacattgagcacctgaagtccgag gtggaggagcagaaggagcagcggatgcgatccctcagctccaccagcagcggcagcaaa gacaaacctggcaaggagtgtgctgatgctgcctccccagctctgtccctagccgaactc aggacaacgtgcagcgagaatgagctggctgcggagttcaccaacgccattcgtcgagaa aagaagttgaaggccagagttcaagagctggtgagtgccttggagagactcaccaagagc agtgaaatccgacatcagcaatctgcagagttcgtgaatgatctaaagcgggccaacagc aacctggtggctgcctatgagaaagcaaagaaaaagcatcaaaacaaactgaagaagtta gagtcgcagatgatggccatggtggagagacatgagacccaagtgaggatgctcaagcaa agaatagctctgctagaggaggagaactccaggccacacaccaatgaaacttcgctttaa |
Protein Sequence |
>4163 : length: 1019 MMAAAAAAAAGSSSSGGGGGGSGSSSSSSDTSSTGEEERMRRLFQTCDGDGDGYISRNDL LMVCRQLNMEESVAEIMNQLGADENGKISFQDFTRCRMQLVREIRKEEVDLSAKSDNSCT KKLRDRIASWPTSSDNSLGALSAARESWEYDSGARDLQSPDVQSQSALQKLLEYGGSSLH QQAALHKLLTQSPHIGNSVGGSYLELANTLHSAALASLKGDIVELNKRLQQTERERDLLE KKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEY SELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLE NVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSR WEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQAT GPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSE ISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHL KSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQ SLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAV AGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLEL ESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKL STREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAEL RTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANS NLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL |